公开(公告)号：US12163149B2

公开(公告)日：2024-12-10

申请号：US18147156

申请日：2022-12-28

Applicant: TOOLGEN INCORPORATED

Inventor： Seokjoong Kim ,  Dong Woo Song ,  Jae Young Lee ,  Jung Min Lee ,  Gyu-bon Cho ,  Hee Sook Bae

IPC: C07H21/02 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85

Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.

公开(公告)号：US11572574B2

公开(公告)日：2023-02-07

申请号：US16776707

申请日：2020-01-30

Applicant: TOOLGEN INCORPORATED

Inventor： Seokjoong Kim ,  Dong Woo Song ,  Jae Young Lee ,  Jung Min Lee ,  Gyu-bon Cho ,  Hee Sook Bae

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N15/113 ,  C12N9/22

Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.

公开(公告)号：US20240216539A1

公开(公告)日：2024-07-04

申请号：US18590251

申请日：2024-02-28

Applicant: TOOLGEN INCORPORATED ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Jae Young Lee ,  Sang Woo Ham ,  Hee Sook Bae ,  Gyu Bon Cho ,  Jae Hyung Jang ,  Yun Ha Kim ,  Dong Soo Lee

IPC: A61K48/00 ,  A61K47/69 ,  C12N15/86

CPC classification number: A61K48/005 ,  A61K47/6901 ,  C12N15/86 ,  C12N2750/14143

Abstract: The present application relates to a vector for delivering an active agent to the nervous system. In one embodiment of the present application, a vector for delivering an active agent in which one or more TTR ligands are conjugated to the surface of an adeno-associated virus is provided.