公开(公告)号：US12163149B2

公开(公告)日：2024-12-10

申请号：US18147156

申请日：2022-12-28

Applicant: TOOLGEN INCORPORATED

Inventor： Seokjoong Kim ,  Dong Woo Song ,  Jae Young Lee ,  Jung Min Lee ,  Gyu-bon Cho ,  Hee Sook Bae

IPC: C07H21/02 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85

Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.

公开(公告)号：US20240301424A1

公开(公告)日：2024-09-12

申请号：US18657145

申请日：2024-05-07

Applicant: Toolgen Incorporated

Inventor： Seok Joong Kim ,  Yoon-Young Kim ,  Ho-Sung Yu ,  In-Young Jung ,  Jung Min Lee

IPC: C12N15/113 ,  A61K35/14 ,  C07K14/705 ,  C12N5/0783 ,  C12N5/0784 ,  C12N9/22 ,  C12N15/10 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85

CPC classification number: C12N15/1132 ,  A61K35/14 ,  C07K14/70503 ,  C07K14/70564 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/70596 ,  C12N5/0637 ,  C12N5/0638 ,  C12N5/064 ,  C12N5/0646 ,  C12N15/102 ,  C12N15/1138 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  C12N9/22 ,  C12N2310/20 ,  C12N2320/30 ,  Y02A50/30

Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof

公开(公告)号：US12275963B2

公开(公告)日：2025-04-15

申请号：US16611383

申请日：2018-05-08

Applicant: TOOLGEN INCORPORATED

Inventor： Seok Joong Kim ,  Yoon-Young Kim ,  Ho-Sung Yu ,  In-Young Jung ,  Jung Min Lee

IPC: A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/078 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/10 ,  C12N15/113 ,  C12N15/115 ,  C12N15/117 ,  C12N15/87 ,  C07K14/725

Abstract: The presents invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell. More particularly, the present invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell and a manipulated immune cell comprising an artificially modified immunity regulating gene and an artificial receptor which is produced using the composition, and use thereof.

公开(公告)号：US11572574B2

公开(公告)日：2023-02-07

申请号：US16776707

申请日：2020-01-30

Applicant: TOOLGEN INCORPORATED

Inventor： Seokjoong Kim ,  Dong Woo Song ,  Jae Young Lee ,  Jung Min Lee ,  Gyu-bon Cho ,  Hee Sook Bae

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N15/113 ,  C12N9/22

Abstract: The present invention relates to an expression control composition for controlling the expression of a duplicate gene or a method using the same. In addition, the present invention relates to a method of treating or improving a disease caused by gene duplication using the expression control composition for controlling the expression of a duplicate gene.

公开(公告)号：US11845951B2

公开(公告)日：2023-12-19

申请号：US16650993

申请日：2018-09-28

Applicant: TOOLGEN INCORPORATED ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  SEOUL NATIONAL UNIVERSITY HOSPITAL

Inventor： Dong Woo Song ,  Jung Min Lee ,  Un Gi Kim ,  Jeong Hun Kim ,  Dong Hyun Jo

IPC: C12N15/86 ,  C12N15/113 ,  C12N9/22 ,  A61P27/02 ,  A61K48/00

CPC classification number: C12N15/86 ,  A61P27/02 ,  C12N9/22 ,  C12N15/113 ,  A61K48/00 ,  C12N2310/20 ,  C12N2800/80

Abstract: The present invention relates to a composition for gene manipulation for treating or improving a retinal dysfunction disease or a method using the same. More particularly, the present invention relates to a composition for gene manipulation including a guide nucleic acid capable of targeting a retinal function-forming gene and a method of treating or improving a disease caused by retinal dysfunction by artificially manipulating and/or correcting a retinal function-forming gene using the same.

公开(公告)号：US12012598B2

公开(公告)日：2024-06-18

申请号：US16324955

申请日：2017-08-14

Applicant: TOOLGEN INCORPORATED

Inventor： Seok Joong Kim ,  Yoon-Young Kim ,  Ho-Sung Yu ,  In-Young Jung ,  Jung Min Lee

IPC: C12N15/113 ,  A61K35/14 ,  C07K1/00 ,  C07K14/705 ,  C12N5/0783 ,  C12N5/0784 ,  C12N15/10 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  A61K31/70 ,  C12N9/22

CPC classification number: C12N15/1132 ,  A61K35/14 ,  C07K14/70503 ,  C07K14/70564 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/70596 ,  C12N5/0637 ,  C12N5/0638 ,  C12N5/064 ,  C12N5/0646 ,  C12N15/102 ,  C12N15/1138 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  C12N9/22 ,  C12N2310/20 ,  C12N2320/30 ,  Y02A50/30

Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.