公开(公告)号：US11441135B2

公开(公告)日：2022-09-13

申请号：US16628199

申请日：2018-07-06

Applicant: TOOLGEN INCORPORATED

Inventor： Young-Hoon Kim ,  Min Hee Jung ,  Joonsun Lee ,  Eunji Shin ,  Kang In Lee ,  Seokjoong Kim ,  Jeongjoon Lee

IPC: C12N9/22 ,  C12N9/78 ,  C12N15/86

Abstract: The present invention relates to an artificially engineered CRISPR/Cas9 system. More particularly, the present invention relates to an artificially engineered CRISPR enzyme having enhanced target specificity and a use of an artificially engineered CRISPR/Cas9 system including the same enzyme in genome and/or epigenome manipulation or modification, genome targeting, genome editing, and in vitro diagnosis, etc.