公开(公告)号：US12286635B2

公开(公告)日：2025-04-29

申请号：US17706921

申请日：2022-03-29

Applicant: TOOLGEN INCORPORATED

Inventor： Seok Joong Kim ,  Ok Jae Koo ,  Min Hee Jung ,  Ye Seul Kim

IPC: C12N15/82 ,  C12N9/22 ,  C12N15/11

Abstract: The present invention relates to an artificially manipulated unsaturated fatty acid biosynthesis-associated factor and use thereof to increase the content of a specific unsaturated fatty acid of a plant body. More particularly, the present invention relates to a system capable of artificially controlling unsaturated fatty acid biosynthesis and a plant body produced thereby, which include an artificially manipulated unsaturated fatty acid biosynthesis-associated factor to control unsaturated fatty acid biosynthesis and a composition capable of artificially manipulating the factor. In a specific aspect, the present invention relates to artificially manipulated unsaturated fatty acid biosynthesis-associated factors such as FAD2, FAD3, FADE, FAD7 and FAD8 and/or an unsaturated fatty acid biosynthesis controlling system by an expression product thereof.

公开(公告)号：US11441135B2

公开(公告)日：2022-09-13

申请号：US16628199

申请日：2018-07-06

Applicant: TOOLGEN INCORPORATED

Inventor： Young-Hoon Kim ,  Min Hee Jung ,  Joonsun Lee ,  Eunji Shin ,  Kang In Lee ,  Seokjoong Kim ,  Jeongjoon Lee

IPC: C12N9/22 ,  C12N9/78 ,  C12N15/86

Abstract: The present invention relates to an artificially engineered CRISPR/Cas9 system. More particularly, the present invention relates to an artificially engineered CRISPR enzyme having enhanced target specificity and a use of an artificially engineered CRISPR/Cas9 system including the same enzyme in genome and/or epigenome manipulation or modification, genome targeting, genome editing, and in vitro diagnosis, etc.