公开(公告)号：US20220204955A1

公开(公告)日：2022-06-30

申请号：US17606502

申请日：2019-04-26

Applicant: TOOLGEN INCORPORATED

Inventor： Joon Sun LEE ,  Min Hee JUNG ,  Yu Ri CHOI ,  Jeong Joon LEE

IPC: C12N9/22 ,  C12N15/11 ,  C12N15/88 ,  C12N15/85

Abstract: The present invention relates to an artificially engineered CRISPR/Cas9 system. More particularly, the present invention relates to an artificially engineered CRISPR enzyme having enhanced target specificity and a use of an artificially engineered CRISPR/Cas9 system including the same enzyme in genome and/or epigenome manipulation or modification, genome targeting, genome editing, and in vitro diagnosis, etc.