公开(公告)号：US20230190889A1

公开(公告)日：2023-06-22

申请号：US18157329

申请日：2023-01-20

Applicant: TOOLGEN INCORPORATED

Inventor： DONG WOO SONG ,  BEOMSEOK CHOI ,  HYEKYUNG OH ,  NANYEONG GO ,  HYERIM LEE ,  KYU JUN LEE ,  UN GI KIM ,  JAEYOUNG LEE ,  JUNG MIN LEE

IPC: A61K38/46 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  A61K31/7105 ,  A61P7/04

CPC classification number: A61K38/465 ,  A61K31/7105 ,  A61P7/04 ,  C12N9/22 ,  C12N15/11 ,  C12N15/86 ,  C12N2310/20 ,  C12N2750/14143 ,  C12N2750/14171 ,  C12N2800/80

Abstract: The present disclosure relates to a composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene present in the genome of a cell to regulate a blood coagulation system. More particularly, the present invention relates to a composition for gene manipulation, which includes a guide nucleic acid capable of targeting a blood coagulation inhibitory gene, and an editor protein. Also, the present invention relates to a method of treating or improving coagulopathy using the composition for gene manipulation for artificially manipulating a blood coagulation inhibitory gene.