公开(公告)号：US12275963B2

公开(公告)日：2025-04-15

申请号：US16611383

申请日：2018-05-08

Applicant: TOOLGEN INCORPORATED

Inventor： Seok Joong Kim ,  Yoon-Young Kim ,  Ho-Sung Yu ,  In-Young Jung ,  Jung Min Lee

IPC: A61K39/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/078 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/10 ,  C12N15/113 ,  C12N15/115 ,  C12N15/117 ,  C12N15/87 ,  C07K14/725

Abstract: The presents invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell. More particularly, the present invention relates to a composition for manipulating an immune cell which is used for artificially manipulating an immune cell and a manipulated immune cell comprising an artificially modified immunity regulating gene and an artificial receptor which is produced using the composition, and use thereof.

公开(公告)号：US20240301424A1

公开(公告)日：2024-09-12

申请号：US18657145

申请日：2024-05-07

Applicant: Toolgen Incorporated

Inventor： Seok Joong Kim ,  Yoon-Young Kim ,  Ho-Sung Yu ,  In-Young Jung ,  Jung Min Lee

IPC: C12N15/113 ,  A61K35/14 ,  C07K14/705 ,  C12N5/0783 ,  C12N5/0784 ,  C12N9/22 ,  C12N15/10 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85

CPC classification number: C12N15/1132 ,  A61K35/14 ,  C07K14/70503 ,  C07K14/70564 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/70596 ,  C12N5/0637 ,  C12N5/0638 ,  C12N5/064 ,  C12N5/0646 ,  C12N15/102 ,  C12N15/1138 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  C12N9/22 ,  C12N2310/20 ,  C12N2320/30 ,  Y02A50/30

Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof

公开(公告)号：US12012598B2

公开(公告)日：2024-06-18

申请号：US16324955

申请日：2017-08-14

Applicant: TOOLGEN INCORPORATED

Inventor： Seok Joong Kim ,  Yoon-Young Kim ,  Ho-Sung Yu ,  In-Young Jung ,  Jung Min Lee

IPC: C12N15/113 ,  A61K35/14 ,  C07K1/00 ,  C07K14/705 ,  C12N5/0783 ,  C12N5/0784 ,  C12N15/10 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  A61K31/70 ,  C12N9/22

CPC classification number: C12N15/1132 ,  A61K35/14 ,  C07K14/70503 ,  C07K14/70564 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/70596 ,  C12N5/0637 ,  C12N5/0638 ,  C12N5/064 ,  C12N5/0646 ,  C12N15/102 ,  C12N15/1138 ,  C12N15/52 ,  C12N15/63 ,  C12N15/85 ,  C12N9/22 ,  C12N2310/20 ,  C12N2320/30 ,  Y02A50/30

Abstract: The present invention relates to an artificially manipulated immune system having an improved immune effect. More particularly, the present invention relates to an immune system having functions artificially altered which comprises artificially manipulated immunoregulatory elements and cells containing the same. Contemplated according to a particular embodiment is an immune system comprising artificially manipulated immunoregulatory genes such as PD-1, CTLA-4, A20, DGKα, DGKζ, FAS, EGR2, PPP2R2D, PSGL-1, KDM6A, and TET2, and/or expression products thereof.