公开(公告)号：US20240301347A1

公开(公告)日：2024-09-12

申请号：US18578247

申请日：2022-06-29

Applicant: TOPPAN INC. ,  OSAKA UNIVERSITY

Inventor： Asuka YAMADA ,  Shiro KITANO ,  Michiya MATSUSAKI

IPC: C12N5/00

CPC classification number: C12N5/0068 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2537/00

Abstract: One aspect of the present invention relates to a production method of a fragmented extracellular matrix component, the method including: a step of neutralizing a solution in which an extracellular matrix component is dissolved; a step of obtaining a mass containing the extracellular matrix component by removing the solvent through freeze-drying treatment after the neutralization step; a step of obtaining a liquid containing the fragmented extracellular matrix component by dispersing the mass in a solution containing a polar organic solvent and fragmenting the extracellular matrix component in the solution; and a step of removing a liquid component from the liquid containing the fragmented extracellular matrix component.