-
公开(公告)号：US11479764B2
公开(公告)日：2022-10-25
申请号：US16951456
申请日：2020-11-18
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroki Nagase , Kei Tsukamoto , Shiro Kitano
Abstract: A method of separating a target double-stranded nucleic acid molecule from a sample including the target double-stranded nucleic acid molecule and a non-target double-stranded nucleic acid molecule, including (1) mixing the sample, a pyrrole-imidazole-containing polyamide (first PI polyamide) modified with a first linker molecule and capable of specifically binding to a sequence of the target double-stranded nucleic acid molecule, and a carrier a modified with a first ligand capable of specifically binding and/or adsorbing to the first linker molecule such that a mixed solution is produced, (2) forming a complex A by binding the carrier a to the first PI polyamide with which the target double-stranded nucleic acid molecule is bound in the mixed solution, and (3) separating the complex A from the mixed solution.
-
公开(公告)号：US10858646B2
公开(公告)日：2020-12-08
申请号：US15948124
申请日：2018-04-09
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Hiroki Nagase , Kei Tsukamoto , Shiro Kitano
Abstract: A method of separating a target double-stranded nucleic acid molecule from a sample including the target double-stranded nucleic acid molecule and a non-target double-stranded nucleic acid molecule, including (1) mixing the sample, a pyrrole-imidazole-containing polyamide (first PI polyamide) modified with a first linker molecule and capable of specifically binding to a sequence of the target double-stranded nucleic acid molecule, and a carrier a modified with a first ligand capable of specifically binding and/or adsorbing to the first linker molecule such that a mixed solution is produced, (2) forming a complex A by binding the carrier a to the first PI polyamide with which the target double-stranded nucleic acid molecule is bound in the mixed solution, and (3) separating the complex A from the mixed solution.
-
Search Results
2
records
(took 0.01 seconds)
