公开(公告)号：US11478539B2

公开(公告)日：2022-10-25

申请号：US16746204

申请日：2020-01-17

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Fumiyoshi Okano

IPC: A61K39/00 ,  A61K35/15 ,  A61K35/17 ,  A61K48/00 ,  A61K31/7088 ,  A61P35/02 ,  A61P35/00

Abstract: This application provides an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from (a) polypeptides consisting of amino acid sequences represented by SEQ ID NO: 8, 4, 6, 10, 12, 2 and 14, and polypeptides consisting of 7 or more consecutive amino acids in the amino acid sequences, (b) polypeptides having a sequence identity of 85% or more with the amino acid sequences represented by SEQ ID NO: 8, 4, 6, 10, 12, 2 and 14, and polypeptides consisting of 7 or more consecutive amino acids in the amino acid sequences, and (c) polypeptides comprising the polypeptides according to (a) or (b) as the partial sequences, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo.

公开(公告)号：US10537623B2

公开(公告)日：2020-01-21

申请号：US14869523

申请日：2015-09-29

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Fumiyoshi Okano

IPC: A61K39/00 ,  A61K39/39 ,  A61K38/21 ,  A61K38/44 ,  A61K38/20 ,  C12N9/02

Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a). Further, an in vitro method for preparing an antigen-presenting cell is provided. The method includes the step of contacting the antigen-presenting cell with the at least one polypeptide selected from: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

公开(公告)号：US10463725B2

公开(公告)日：2019-11-05

申请号：US14882307

申请日：2015-10-13

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Fumiyoshi Okano

IPC: A61K39/00 ,  C07K14/47 ,  A61K45/06 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/20 ,  A61K38/21 ,  A61K38/17

Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 8, 10 and 12; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

公开(公告)号：US10251942B2

公开(公告)日：2019-04-09

申请号：US15008101

申请日：2016-01-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Fumiyoshi Okano

IPC: A61K39/00 ,  A61K38/16 ,  A61K35/17 ,  C12N5/0783 ,  C12N5/0784 ,  C12Q1/6886 ,  C07K1/00

Abstract: An immunity-inducing agent comprising as an effective ingredient(s) a polypeptide(s) selected from the polypeptides: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in SEQ ID NOs:2, 4, 6, 8, 10, 12 and 44 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof; which polypeptide(s) has/have an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo, is useful as a therapeutic and/or prophylactic agent for cancer, and/or the like.

公开(公告)号：US11510971B2

公开(公告)日：2022-11-29

申请号：US15743869

申请日：2016-08-05

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Fumiyoshi Okano

IPC: A61K39/00 ,  C07K14/47 ,  A61K45/00 ,  A61K48/00 ,  A61K39/39 ,  C12N5/10 ,  C12N15/09 ,  A61K35/15 ,  A61K35/76 ,  A61K35/17 ,  A61P35/00

Abstract: An object of the present invention is to discover a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer. The immune inducer contains as an active ingredient, the following (i) or (ii): (i) at least one polypeptide having an immune-inducing activity and selected from the group of polypeptides (a) or (b), where: (a) polypeptides consisting of 7 or more consecutive amino acids within the region of positions 24 to 97 in the amino acid sequence represented by SEQ ID NO: 2; and (b) polypeptides comprising one to several amino acid deletions, substitutions and/or additions in the amino acid sequence of any one of the polypeptides (a); and (ii) a recombinant vector comprising at least one polynucleotide encoding any one of the polypeptides, and capable of expressing the polypeptide in vivo.

公开(公告)号：US11318185B2

公开(公告)日：2022-05-03

申请号：US16080857

申请日：2017-03-01

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Fumiyoshi Okano

IPC: A61K38/17 ,  A61K38/43 ,  A61K35/15 ,  A61K38/08 ,  A61K35/76 ,  A61K38/00 ,  A61K45/00 ,  A61P35/00 ,  C12N15/62 ,  C12N9/24

Abstract: The present invention addresses the problem of finding a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer.
The immune inducer containing as an active ingredient: (a) a polypeptide consisting of any one of the amino acid sequences represented by SEQ ID NOs: 3 to 45; or (b) a polypeptide comprising one to several amino acid deletions, substitutions or additions in the amino acid sequence of the polypeptide (a); is useful as an agent for treating or preventing cancer, etc.

公开(公告)号：US11129893B2

公开(公告)日：2021-09-28

申请号：US15567496

申请日：2016-04-28

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira Kurihara ,  Hyongi Chon ,  Takayuki Fujita ,  Fumiyoshi Okano

IPC: A61K39/395 ,  C07K16/28 ,  A61P35/02 ,  C07K4/12 ,  A61K39/00

Abstract: An object of the present invention is to identify a cancer antigen protein specifically expressed on the surface of cancer cells and provide use of an antibody targeting the cancer antigen protein as a therapeutic and/or prophylactic agent for cancer. A pharmaceutical composition for treating and/or preventing cancer comprising an antibody or a fragment thereof having immunological reactivity with CSPG5 protein consisting of any one of amino acid sequences represented by SEQ ID NOs: 8, 4, 6, 10, and 12 and an amino acid sequence having an amino acid identity of 80% or more to the amino acid sequence, or a fragment thereof consisting of 7 or more consecutive amino acids, as an active ingredient.