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公开(公告)号：US20220362742A1
公开(公告)日：2022-11-17
申请号：US17764436
申请日：2020-10-02
IPC分类号： B01J20/26 , B01J20/28 , B01J20/289 , B01J20/32 , B01D15/08
摘要： A blood treatment material adsorbs and removes blood components such as activated leukocytes and inflammatory cytokines with a high efficiency. The blood treatment material includes a water-insoluble material in the form of fibers or particles, wherein the difference between the maximum value (RaA) and the minimum value (RaB) of the arithmetic average roughness (Ra) of the surface of the water-insoluble material, as calculated using a laser microscope, is from 0.30 to 1.50 μm.
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公开(公告)号：US10888840B2
公开(公告)日：2021-01-12
申请号：US16615295
申请日：2018-06-06
IPC分类号： B01J20/28 , B01J20/26 , A61M1/36 , B01D15/38 , B01J20/288
摘要： An object of the present invention is to provide a material which can remove an activated leukocyte-activated platelet complex with high efficiency. The present invention provides a material for removing an activated leukocyte-activated platelet complex, the material being a water-insoluble carrier to the surface of which carrier a compound(s) having a charged functional group(s) is(are) bound, wherein an extending length ratio of the surface is 4 to 7.
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公开(公告)号：US11992598B2
公开(公告)日：2024-05-28
申请号：US17442247
申请日：2020-04-21
CPC分类号： A61M1/3679 , B01J20/26
摘要： The present invention aims to provide a material for adsorbing soluble tumor necrosis factor receptors with high efficiency. The present invention provides an adsorbing material for soluble tumor necrosis factor receptors, which includes a superficially porous water-insoluble polymeric material, wherein the pore size distribution curve for the surface of the water-insoluble polymeric material, which is derived from a distribution of melting points determined by differential scanning calorimeter, shows the peak radius in the range of 1 to 80 nm, and the water-insoluble polymeric material has a zeta potential at pH 7.4 of −15 to 15 mV, and the water-insoluble polymeric material is in fiber, particle, or film form.
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公开(公告)号：US20240116004A1
公开(公告)日：2024-04-11
申请号：US18285500
申请日：2022-04-15
CPC分类号： B01D69/02 , B01D69/081 , B01D71/421 , B01D71/76 , A61M1/3687
摘要： A blood treatment material has both the water permeability to allow removal of water from the blood and the ability to highly efficiently adsorb and remove, for example, inflammatory cells and inflammatory cytokines. The blood treatment material includes a hollow fiber membrane having a surface modified with a ligand containing an amino group(s), wherein the arithmetic mean roughness (RaA) of the blood-contacting surface of the hollow fiber membrane in the radial direction calculated by using a laser microscope is 0.10 μm to 0.80 μm.
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公开(公告)号：US10646850B2
公开(公告)日：2020-05-12
申请号：US16327188
申请日：2017-09-08
发明人： Shungo Kanda , Hiroshi Takahashi , Naotoshi Tomita
摘要： An object of the present invention is to provide a material for blood purification having the capability to remove cytokines and activated leukocyte-activated platelet complexes. The present invention provides a material for blood purification, the material containing a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.
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公开(公告)号：US10308745B2
公开(公告)日：2019-06-04
申请号：US15556002
申请日：2016-03-15
发明人： Suguru Ushiro , Hiroshi Takahashi , Yoshiyuki Ueno
IPC分类号： C08F226/10 , B01D71/44 , B01D71/68 , A61K35/16 , A61M1/16 , A61M1/34 , B01D71/76 , C09D139/06 , C08F218/10 , B01D67/00 , B01D69/06 , B01D69/08 , A61L33/06 , C08F226/06 , B01D71/38
摘要： A copolymer has blood compatibility and antithrombotic properties of greatly suppressing protein adhesion to be usable even when in contact with a biological component such as blood for a long period of time, and a medical device uses the copolymer. The copolymer is characterized by including a hydrophilic unit and a hydrophobic unit, wherein the hydrophobic unit contains at least one type of a carboxylic acid vinyl unit, and the number of carbon atoms at the terminal of a side chain of the carboxylic acid vinyl unit is 2-7.
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公开(公告)号：US11660383B2
公开(公告)日：2023-05-30
申请号：US17113726
申请日：2020-12-07
IPC分类号： A61M1/36 , B01J20/26 , B01J20/28 , B01D15/38 , B01J20/288
CPC分类号： A61M1/3679 , A61M1/362 , B01D15/3823 , B01J20/265 , B01J20/28 , B01J20/288 , B01J20/28023 , B01J20/28054 , A61M2202/0057 , A61M2202/0427 , A61M2202/0439 , A61M2202/0447 , A61M2202/07 , B01J2220/50
摘要： An object of the present invention is to provide a material which can remove an activated leukocyte-activated platelet complex with high efficiency. The present invention provides a material for removing an activated leukocyte-activated platelet complex, the material being a water-insoluble carrier to the surface of which carrier a compound(s) having a charged functional group(s) is(are) bound, wherein an extending length ratio of the surface is 4 to 7.
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公开(公告)号：US11185844B2
公开(公告)日：2021-11-30
申请号：US17058951
申请日：2019-07-05
发明人： Shungo Kanda , Kaoru Shimada , Shunsuke Komachi , Hiroshi Takahashi , Hirofumi Yamanaka , Masato Masuda
摘要： An object of the present invention is to provide a carrier for adsorbing organic matter, which achieves both of adsorption ability for organic matter and suppression of pressure increase. The present invention provides a carrier for adsorbing organic matter, comprising a sea-island type solid composite fiber, wherein the pore volume is 0.05 to 0.5 cm3/g and the fiber diameter is 25 to 60 μm.
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