公开(公告)号：US20200062736A1

公开(公告)日：2020-02-27

申请号：US16469865

申请日：2017-12-15

Applicant: NOVA SOUTHEASTERN UNIVERSITY ,  AUBURN UNIVERSITY ,  FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

Inventor： Dmitriy Minond ,  Gregg B. Fields ,  Marcello Giulianotti

IPC: C07D403/14 ,  G01N33/50 ,  G01N33/564 ,  G01N33/566 ,  A61P35/02

Abstract: The invention provides methods for treating cancers, such as melanoma and/or metastatic melanoma, using compounds that interact with and/or inhibit cellular proteins lamin A/C, ATP-dependent RNA helicase DDX1 (DDX1), heterogeneous nuclear ribonuclear protein H1/H2 (hnRNP H2), and/or heterogeneous nuclear ribonuclear protein A2/B1 (hnRNP A2/B1). The invention additionally provides a method for identifying compounds active against melanoma cells.

公开(公告)号：US20150315179A1

公开(公告)日：2015-11-05

申请号：US14700699

申请日：2015-04-30

Applicant: Torrey Pines Institute For Molecular Studies

Inventor： Madepalli K. Lakshmana ,  Adel Nefzi ,  Richard Houghten ,  Dmitriy Minond

IPC: C07D417/12 ,  C07D277/42

CPC classification number: C07D277/42 ,  C07D417/12 ,  C07D417/14

Abstract: Embodiments of the present disclosure provide for compositions including a compound, pharmaceutical compositions including the compound, methods of treatment of a disease or related condition (e.g., neurological disease on condition), methods of treatment using compositions or pharmaceutical compositions, and the like.

Abstract translation: 本公开的实施方案提供了包含化合物，包含该化合物的药物组合物，治疗疾病或相关病症的方法（例如，状况下的神经疾病），使用组合物或药物组合物的治疗方法等的组合物。

公开(公告)号：US11149028B2

公开(公告)日：2021-10-19

申请号：US16469865

申请日：2017-12-15

Applicant: NOVA SOUTHEASTERN UNIVERSITY ,  AUBURN UNIVERSITY ,  FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

Inventor： Dmitriy Minond ,  Gregg B. Fields ,  Marcello Giulianotti

IPC: A61K31/495 ,  C07D403/14 ,  A61P35/02 ,  G01N33/50 ,  G01N33/564 ,  G01N33/566

Abstract: The invention provides methods for treating cancers, such as melanoma and/or metastatic melanoma, using compounds that interact with and/or inhibit cellular proteins lamin A/C, ATP-dependent RNA helicase DDX1 (DDX1), heterogeneous nuclear ribonuclear protein H1/H2 (hnRNP H2), and/or heterogeneous nuclear ribonuclear protein A2/B1 (hnRNP A2/B1). The invention additionally provides a method for identifying compounds active against melanoma cells.

公开(公告)号：US09994536B2

公开(公告)日：2018-06-12

申请号：US15306824

申请日：2015-05-01

Applicant: TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

Inventor： Madepalli K. Lakshmana ,  Adel Nefzi ,  Richard Houghten ,  Dmitriy Minond

IPC: C07D277/42

CPC classification number: C07D277/42 ,  C07D417/12 ,  C07D417/14

Abstract: Embodiments of the present disclosure provide for compositions including a compound, pharmaceutical compositions including the compound, methods of treatment of a disease or related condition (e.g., neurological disease on condition), methods of treatment using compositions or pharmaceutical compositions, and the like.