公开(公告)号：US20030175243A1

公开(公告)日：2003-09-18

申请号：US10402954

申请日：2003-04-01

申请人： TRANSGENE S.A.

发明人： Valerie Legrand ,  Majid Mehtali ,  Pierre Boulanger

IPC分类号： A61K048/00 ,  C12N007/00 ,  C12N015/861 ,  C12N005/00

CPC分类号： C12N7/00 ,  A61K38/00 ,  C07K14/005 ,  C07K2319/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/851 ,  C12N2830/00 ,  C12N2830/42 ,  C12N2830/60

摘要： The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.

公开(公告)号：US20040038205A1

公开(公告)日：2004-02-26

申请号：US10670503

申请日：2003-09-26

申请人： TRANSGENE, S.A.

发明人： Mark Johan Van Raaij ,  Stephen Cusack ,  Valerie Legrand ,  Philippe Leissner ,  Majid Mehtali

IPC分类号： C07K014/075 ,  C12Q001/70 ,  C12N007/00

CPC分类号： C07K14/005 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/10 ,  C12N2810/40 ,  C12N2810/851 ,  C12N2810/854 ,  C12N2810/859

摘要： The present invention relates to a modified fiber of an adenovirus, comprising at least one mutation at one or more residues within the region of said fiber stretching from pleated sheet A to pleated sheet B, and including loop AB.

摘要翻译： 本发明涉及一种腺病毒的修饰纤维，其包含在从褶皱片材A到褶皱片材B拉伸的所述纤维区域内的一个或多个残基的至少一个突变，并且包括环AB。