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公开(公告)号：US20080008703A1
公开(公告)日：2008-01-10
申请号：US11722094
申请日：2005-12-29
申请人： Tae Hyoung Yoo , Moo Young Song , Chang Seok Kim , Sang Koo Park , Kang In Na , Byung Kyu Lee , Heui Il Kang
发明人： Tae Hyoung Yoo , Moo Young Song , Chang Seok Kim , Sang Koo Park , Kang In Na , Byung Kyu Lee , Heui Il Kang
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Humanized antibodies specifically binding to hTNF-α are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the original mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-α-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.
摘要翻译： 通过CDR（互补决定区）接枝方法由小鼠单克隆抗体制备与hTNF-α特异性结合的人源化抗体，它们显示与原始小鼠单克隆抗体相似的抗原结合亲和力，并且显着低的免疫原性。 因此，人源化抗体可以有效地用于治疗hTNF-α相关疾病如类风湿性关节炎，克罗恩病，牛皮癣关节炎，银屑病，败血病，哮喘，韦格纳肉芽肿病，炎症和强直性脊柱炎。
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公开(公告)号：US07645450B2
公开(公告)日：2010-01-12
申请号：US11722094
申请日：2005-12-29
申请人： Tae Hyoung Yoo , Moo Young Song , Chang Seok Kim , Sang Koo Park , Kang In Na , Byung Kyu Lee , Heui Il Kang
发明人： Tae Hyoung Yoo , Moo Young Song , Chang Seok Kim , Sang Koo Park , Kang In Na , Byung Kyu Lee , Heui Il Kang
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Humanized antibodies specifically binding to hTNF-α are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the original mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-α-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.
摘要翻译： 通过CDR（互补决定区）接枝方法由小鼠单克隆抗体制备与hTNF-α特异性结合的人源化抗体，它们显示与原始小鼠单克隆抗体相似的抗原结合亲和力，并且显着低的免疫原性。 因此，人源化抗体可以有效地用于治疗hTNF-α相关疾病如类风湿性关节炎，克罗恩病，牛皮癣关节炎，银屑病，败血病，哮喘，韦格纳肉芽肿病，炎症和强直性脊柱炎。
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公开(公告)号：US07435414B2
公开(公告)日：2008-10-14
申请号：US11100553
申请日：2005-04-07
申请人： Heui Il Kang , Byung Kyu Lee , Se Cheol Park , Moo Young Song , Tae Hyoung Yoo , Jae Sun Lee , Chang Seok Kim , Sang Koo Park , Kang In Na
发明人： Heui Il Kang , Byung Kyu Lee , Se Cheol Park , Moo Young Song , Tae Hyoung Yoo , Jae Sun Lee , Chang Seok Kim , Sang Koo Park , Kang In Na
IPC分类号： A61K39/395
CPC分类号： C07K16/082 , C07K2317/24
摘要： A humanized antibody of the present invention shows similar antigen-binding affinity to a mouse monoclonal antibody and significantly low immunogenecity. Therefore, the humanized antibody of the present invention can be effectively used for treating chronic hepatitis B and preventing HBV infection of a patient received liver transplantation and vertical transmission from a mother infected with HBV to a fetus.
摘要翻译： 本发明的人源化抗体对小鼠单克隆抗体显示出类似的抗原结合亲和力，并且显着低的免疫原性。 因此，本发明的人源化抗体可以有效地用于治疗慢性乙型肝炎并预防接受肝移植的患者和从感染HBV的母亲到胎儿的垂直传播的HBV感染。
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4.发明授权Nucleic acid molecules encoding human tumor necrosis factor α-specific antibodies 失效编码人肿瘤坏死因子α特异性抗体的核酸分子公开(公告)号：US07109320B2
公开(公告)日：2006-09-19
申请号：US10988617
申请日：2004-11-16
申请人： Heui Il Kang , In Young Ko , Moo Young Song , Chang Seok Kim , Sang Koo Park , Jae Sun Lee , Tae Hyoung Yoo , Kang In Na
发明人： Heui Il Kang , In Young Ko , Moo Young Song , Chang Seok Kim , Sang Koo Park , Jae Sun Lee , Tae Hyoung Yoo , Kang In Na
CPC分类号： C07K16/241 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： An antibody variable region of a monoclonal antibody specifically binding to human tumor necrosis factor-α contains at least one of a heavy chain variable region and a light chain variable region having specific complementarity determining regions therein. A nucleic acid molecule encoding the same, a recombinant vector containing the nucleic acid molecule, and a cell transformed with the recombinant vector are also provided.
摘要翻译： 与人肿瘤坏死因子-α特异性结合的单克隆抗体的抗体可变区含有其中具有特异性互补决定区的重链可变区和轻链可变区中的至少一个。 还提供了编码该核酸分子的核酸分子，含有核酸分子的重组载体和用重组载体转化的细胞。
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5.发明授权Antibody variable region of a monoclonal antibody against human tumor necrosis factor alpha and a gene encoding the same 失效针对人肿瘤坏死因子α的单克隆抗体的抗体可变区和编码其的基因公开(公告)号：US07196177B2
公开(公告)日：2007-03-27
申请号：US11376338
申请日：2006-03-16
申请人： Heui II Kang , In Young Ko , Moo Young Song , Chang Seok Kim , Sang Koo Park , Jae Sun Lee , Tae Hyoung Yoo , Kang In Na
发明人： Heui II Kang , In Young Ko , Moo Young Song , Chang Seok Kim , Sang Koo Park , Jae Sun Lee , Tae Hyoung Yoo , Kang In Na
CPC分类号： C07K16/241 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： An antibody variable region of a monoclonal antibody specifically binding to human tumor necrosis factor-α contains at least one of a heavy chain variable region and a light chain variable region having specific complementarity determining regions therein. A nucleic acid molecule encoding the same, a recombinant vector containing the nucleic acid molecule, and a cell transformed with the recombinant vector are also provided.
摘要翻译： 与人肿瘤坏死因子-α特异性结合的单克隆抗体的抗体可变区含有其中具有特异性互补决定区的重链可变区和轻链可变区中的至少一个。 还提供了编码该核酸分子的核酸分子，含有核酸分子的重组载体和用重组载体转化的细胞。
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