专利检索 ap:("Tai Wei Ly" OR "Marie Chantal Siu-Ying Tran" OR "Erik Dean Raaum") AND inv:"Erik Dean Raaum" 第 1 页

1.

发明授权
2,5-disubstituted arylsulfonamide CCR3 antagonists 失效
标题翻译： 2,5-二取代芳基磺酰胺CCR3拮抗剂

公开(公告)号：US08669247B2

公开(公告)日：2014-03-11

申请号：US13846222

申请日：2013-03-18

申请人： Tai Wei Ly , Marie Chantal Siu-Ying Tran , Erik Dean Raaum

发明人： Tai Wei Ly , Marie Chantal Siu-Ying Tran , Erik Dean Raaum

IPC分类号： A61K31/551 , A61K31/445 , A61K31/497 , A61K31/4965

CPC分类号： C07D487/04 , C07C311/29 , C07C323/67 , C07D211/96 , C07D241/04 , C07D243/08 , C07D295/26 , C07D403/04

摘要： Provided herein are 2,5-disubstituted arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.

摘要翻译： 本文提供了可用于调节CCR3活性的2,5-二取代的芳基磺酰胺及其药物组合物。本文还提供其用于治疗，预防或改善CCR3介导的病症，疾病或病症的一种或多种症状的方法。

2.

发明授权
2,5-disubstituted arylsulfonamide CCR3 antagonists 失效
标题翻译： 2,5-二取代芳基磺酰胺CCR3拮抗剂

公开(公告)号：US08399456B2

公开(公告)日：2013-03-19

申请号：US12764900

申请日：2010-04-21

申请人： Tai Wei Ly , Marie Chantal Siu-Ying Tran , Erik Dean Raaum

发明人： Tai Wei Ly , Marie Chantal Siu-Ying Tran , Erik Dean Raaum

IPC分类号： A61K31/551 , A61K31/445 , A61K31/495 , A61K31/5375 , A61K31/4468 , A61K31/454 , A61K31/277 , C07D211/58 , C07D295/14 , C07D243/08 , C07D401/04 , C07D487/04

CPC分类号： C07D487/04 , C07C311/29 , C07C323/67 , C07D211/96 , C07D241/04 , C07D243/08 , C07D295/26 , C07D403/04

摘要： Provided herein are 2,5-disubstituted arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disorder, disease, or condition.

摘要翻译： 本文提供了可用于调节CCR3活性的2,5-二取代的芳基磺酰胺及其药物组合物。本文还提供其用于治疗，预防或改善CCR3介导的病症，疾病或病症的一种或多种症状的方法。

3.

发明授权
Alkylthio pyrimidines as CRTH2 antagonists 有权
标题翻译：烷硫基嘧啶作为CRTH2拮抗剂

公开(公告)号：US08324229B2

公开(公告)日：2012-12-04

申请号：US12679895

申请日：2008-09-24

申请人： Tai Wei Ly , Erik Dean Raaum , Marie Chantal Siu-Ying Tran

发明人： Tai Wei Ly , Erik Dean Raaum , Marie Chantal Siu-Ying Tran

IPC分类号： C07D239/38 , C07D239/47 , A61K31/505

CPC分类号： C07D239/38 , C07D239/47 , C07D239/58 , C07D403/12

摘要： Provided herein are alkylthio substituted pyrimidine compounds having CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity, useful for the treatment or prophylaxis of diseases associated with CRTH2 activity, including the treatment of allergic diseases, eosinophil-related diseases and basophil-related diseases.

摘要翻译： 本文提供了具有CRTH2（在Th2细胞上表达的G蛋白偶联化学引诱物受体）拮抗活性的烷硫基取代的嘧啶化合物，其可用于治疗或预防与CRTH2活性相关的疾病，包括治疗过敏性疾病，嗜酸性粒细胞相关疾病和嗜碱性粒细胞相关疾病。