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32 条记录 (耗时 0.032 秒)

    Azetidinone 4-disulfides
    9.
    发明授权
    Azetidinone 4-disulfides 失效
    氮杂环丁酮4-二硫化物

    公开(公告)号：US4435321A

    公开(公告)日：1984-03-06

    申请号：US211911

    申请日：1980-12-01

    申请人： Takashi Kamiya ,  Yoshihisa Saito ,  Tsutomu Teraji ,  Osamu Nakaguti ,  Teruo Oku

    发明人： Takashi Kamiya ,  Yoshihisa Saito ,  Tsutomu Teraji ,  Osamu Nakaguti ,  Teruo Oku

    IPC分类号： C07D205/08 ,  C07D205/095 ,  C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/44 ,  C07D501/10 ,  C07D501/14 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12

    CPC分类号： C07D499/00 ,  C07D205/08 ,  C07D205/095

    摘要： A process for producing a 2-cephem or 3-cephem derivative compound of the formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted amino radical and R.sub.4 represents hydrogen or a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and the dotted line indicates the alternate bond structure providing 3-cephem or 2-cephem, which comprises:reacting a halogenated derivative selected from the group consisting of a halogenated penam derivative having the formula: ##STR2## a halogenated cephem derivative of the formula: ##STR3## wherein X represents a halogen atom, R.sub.3 represents a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and R.sub.1 is as defined above, or mixtures thereof with a dehydrohalogenoic acid reagent.

    摘要翻译： 制备下式的2-头孢烯或3-头孢烯衍生物的方法：其中R 1表示取代或未取代的氨基，R 4表示氢或选自羧基，被保护的羧基，酯， 酸酰胺，酸酐，酰卤，叠氮化物和羧基盐，虚线表示提供3-头孢烯或2-头孢烯的交替键结构，其包括：使选自卤代对苯二甲酸衍生物 具有下式的化合物：下式的卤代头孢烯衍生物：其中X表示卤素原子，R3表示选自羧基，保护的羧基，酯，酰胺，酸酐，酰卤的基团 ，叠氮化钠和羧基盐，R1如上所定义，或其与脱氢卤代酸试剂的混合物。

    Substituted-phenyl substituted-alkyl ethers and the preparation thereof
    10.
    发明授权
    Substituted-phenyl substituted-alkyl ethers and the preparation thereof 失效
    取代的苯基取代的烷基醚及其制备方法

    公开(公告)号：US4214094A

    公开(公告)日：1980-07-22

    申请号：US782967

    申请日：1977-03-30

    申请人： Takashi Kamiya ,  Yoshihisa Saito

    发明人： Takashi Kamiya ,  Yoshihisa Saito

    IPC分类号： C07D213/74 ,  C07D277/82 ,  C07D295/096 ,  C07D319/20 ,  C07C101/72 ,  A61K31/24

    CPC分类号： C07D213/74 ,  C07D277/82 ,  C07D295/096 ,  C07D319/20

    摘要： The present invention relates to new substituted-phenyl substituted-alkyl ethers and pharmaceutically acceptable salts thereof, which have hypolipidemic activity, and to processes for the preparation thereof, the compound having the following formula ##STR1## wherein R.sub.1 is lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR2## wherein R.sub.3 and R.sub.4 are each hydrogen or lower alkyl,R.sub.5 is carboxy, esterified carboxy or hydroxymethyl and A is lower alkylene;R.sub.2 is hydrogen, lower alkyl, cycloalkyl, aryl, ar(lower)alkyl, a heterocyclic group or a group represented by the formula: ##STR3## and R.sub.6 is hydrogen, hydroxy or lower alkoxy; in which the aryl or the ar(lower)alkyl for R.sub.1 and R.sub.2 may be substituted with halogen, hydroxy or lower alkoxy, and when R.sub.1 and R.sub.2 are both lower alkyl, R.sub.1 and R.sub.2 may be linked together.

    摘要翻译： 本发明涉及具有降血脂活性的新的取代苯基取代烷基醚及其药学上可接受的盐及其制备方法，具有下式的化合物其中R1是低级烷基，环烷基，芳基 ，芳基（低级）烷基，杂环基或由下式表示的基团：其中R 3和R 4各自为氢或低级烷基，R 5为羧基，酯化羧基或羟甲基，A为低级亚烷基; R2是氢，低级烷基，环烷基，芳基，芳基（低级）烷基，杂环基或由下式表示的基团：R6是氢，羟基或低级烷氧基; 其中R 1和R 2的芳基或芳（低级）烷基可以被卤素，羟基或低级烷氧基取代，当R 1和R 2都是低级烷基时，R 1和R 2可以连接在一起。