公开(公告)号：US20090008575A1

公开(公告)日：2009-01-08

申请号：US12119787

申请日：2008-05-13

申请人： Takashi OKAZAKI ,  Hisataka Fujimaki ,  Shinichiro Fujitaka ,  Rintaro Fujimoto ,  Yusuke Fujii ,  Kazuo Hiramoto

发明人： Takashi OKAZAKI ,  Hisataka Fujimaki ,  Shinichiro Fujitaka ,  Rintaro Fujimoto ,  Yusuke Fujii ,  Kazuo Hiramoto

IPC分类号： A61N5/00

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1095

摘要： A particle irradiation apparatus and a particle beam irradiation method that controls the energy and irradiation dose of a particle beam to form a high dose region having a high uniformity of depth-directional spread (Spread Out Bracici Peak, referred to as SOBP). A SOBP having a steep falling edge of the dose distribution on the deep side from the body surface is formed based on a method of superimposing SOBPs each having a small dose distribution width to form a desired SOBP. An energy-spread-device forms a first SOBP having a small dose distribution width; and an energy spread device 2 forms a second SOBP having a small dose distribution width and a steep falling edge of the dose distribution at the deepest portion from the body surface. The thus formed SOBPs are superimposed to form a SOBP having a length suitable for the target region.

摘要翻译： 粒子照射装置和粒子束照射方法，其控制粒子束的能量和照射剂量以形成具有高均匀度的深度方向扩展的高剂量区域（Spread Out Bracici Peak，称为SOBP）。 基于叠加具有小剂量分布宽度的SOBP以形成期望的SOBP的方法形成具有从身体表面的深侧的剂量分布的陡峭下降边缘的SOBP。 能量扩散装置形成具有小剂量分布宽度的第一SOBP; 并且能量扩散装置2形成具有小的剂量分布宽度和剂量分布的陡峭下降边缘的第二SOBP，其在距离体表的最深部分。 将如此形成的SOBP叠加以形成具有适合于目标区域的长度的SOBP。

公开(公告)号：US07838855B2

公开(公告)日：2010-11-23

申请号：US12141603

申请日：2008-06-18

申请人： Yusuke Fujii ,  Hisataka Fujimaki ,  Kazuo Hiramoto

发明人： Yusuke Fujii ,  Hisataka Fujimaki ,  Kazuo Hiramoto

IPC分类号： A61N5/00 ,  H05H13/04 ,  G21K5/10

CPC分类号： A61N5/1048 ,  A61N2005/1087 ,  G21K5/04

摘要： A charged particle irradiation system that positions the beam at a target position to avoid irradiation of normal tissue includes an acceleration system 6 for extracting a charged particle beam, scanning magnets 24 and 25, and charged particle beam position monitors 26 and 27. On the basis of signals received from the charged particle beam position monitors 26 and 27, the control unit 70 calculates a beam position at a target position and then controls the scanning magnets 24 and 25 so that the charged particle beam is moved to a desired irradiation position at the target position. The control unit 70 corrects the value of an excitation current applied to each of the scanning magnets 24 and 25 on a specified cycle basis on the basis of information about the position and the angle of the charged particle beam.

摘要翻译： 将光束定位在目标位置以避免正常组织照射的带电粒子照射系统包括用于提取带电粒子束的加速系统6，扫描磁体24和25以及带电粒子束位置监视器26和27.在此基础上 从充电的粒子束位置监视器26和27接收的信号，控制单元70计算目标位置处的光束位置，然后控制扫描磁体24和25，使得带电粒子束移动到所需的照射位置 目标位置。 控制单元70基于关于带电粒子束的位置和角度的信息，在指定的周期基础上校正施加到每个扫描磁体24和25的激励电流的值。

公开(公告)号：US20090039256A1

公开(公告)日：2009-02-12

申请号：US12141603

申请日：2008-06-18

申请人： Yusuke FUJII ,  Hisataka Fujimaki ,  Kazuo Hiramoto

发明人： Yusuke FUJII ,  Hisataka Fujimaki ,  Kazuo Hiramoto

IPC分类号： G01N23/00

CPC分类号： A61N5/1048 ,  A61N2005/1087 ,  G21K5/04

摘要： A charged particle irradiation system that positions the beam at a target position to avoid irradiation of normal tissue includes an acceleration system 6 for extracting a charged particle beam, scanning magnets 24 and 25, and charged particle beam position monitors 26 and 27. On the basis of signals received from the charged particle beam position monitors 26 and 27, the control unit 70 calculates a beam position at a target position and then controls the scanning magnets 24 and 25 so that the charged particle beam is moved to a desired irradiation position at the target position. The control unit 70 corrects the value of an excitation current applied to each of the scanning magnets 24 and 25 on a specified cycle basis on the basis of information about the position and the angle of the charged particle beam.

摘要翻译： 将光束定位在目标位置以避免正常组织照射的带电粒子照射系统包括用于提取带电粒子束的加速系统6，扫描磁体24和25以及带电粒子束位置监视器26和27.在此基础上 从充电的粒子束位置监视器26和27接收的信号，控制单元70计算目标位置处的光束位置，然后控制扫描磁体24和25，使得带电粒子束移动到所需的照射位置 目标位置。 控制单元70基于关于带电粒子束的位置和角度的信息，在指定的周期基础上校正施加到每个扫描磁体24和25的激励电流的值。

公开(公告)号：US07394082B2

公开(公告)日：2008-07-01

申请号：US11414204

申请日：2006-05-01

申请人： Hisataka Fujimaki ,  Koji Matsuda ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Alfred R. Smith ,  Kazuo Hiramoto

发明人： Hisataka Fujimaki ,  Koji Matsuda ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Alfred R. Smith ,  Kazuo Hiramoto

IPC分类号： A61N5/00

CPC分类号： A61N5/1048 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10 ,  G21K5/04

摘要： The invention is intended to confirm whether the SOBP (spread-out Bragg peak) width is a desired value in real time during beam irradiation, and to improve safety in treatment. Ion beam delivery equipment comprises a beam generator including a synchrotron, an RMW (range modulation wheel) device for forming an SOBP width of an ion beam extracted from the beam generator, a beam delivery nozzle including a reference dose monitor and a main dose monitor which are installed respectively upstream and downstream of the RMW device in the direction of travel of the ion beam, and an SOBP width computing unit for computing the SOBP width of the ion beam, which is formed by the RMW device, based on values detected by both the reference dose monitor and the main dose monitor.

摘要翻译： 本发明旨在确认在光束照射期间SOBP（展​​开布拉格峰）宽度是否是实时的期望值，并且提高了处理中的安全性。 离子束输送设备包括一个光束发生器，它包括同步加速器，用于形成从光束发生器提取的离子束的SOBP宽度的RMW（范围调制轮）装置，包括参考剂量监测器和主剂量监测器 分别安装在RMW装置的上游和下游沿着离子束行进的方向;以及SOBP宽度计算单元，用于根据由两个检测到的值计算由RMW装置形成的离子束的SOBP宽度 参考剂量监测仪和主剂量监测仪。

公开(公告)号：US20070158592A1

公开(公告)日：2007-07-12

申请号：US11714219

申请日：2007-03-06

申请人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred Smith ,  Wayne Newhauser

发明人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred Smith ,  Wayne Newhauser

IPC分类号： H01J37/08

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K5/04 ,  H05H7/04

摘要： The invention is intended to increase the number of patients treatable using one wheel having a thickness varied in the rotating direction to change energy of an ion beam passing the wheel. Ion beam delivery equipment for irradiating an ion beam to a patient for treatment comprises a beam generator for producing and accelerating the ion beam, an beam delivery nozzle including a range modulation wheel which has a predetermined thickness distribution in the rotating direction and is rotated on a travel passage of the ion beam generated from the beam generator to control a range of the ion beam, and an irradiation controller for controlling the beam producing and accelerating operation of the beam generator in accordance with the phase of rotation of the range modulation wheel.

摘要翻译： 本发明旨在增加使用具有在旋转方向上变化的厚度的一个车轮来治疗的患者数量，以改变通过车轮的离子束的能量。 用于将离子束照射到患者进行治疗的离子束输送设备包括用于产生和加速离子束的束发生器，包括在旋转方向上具有预定厚度分布并在旋转方向上旋转的范围调制轮的束输送喷嘴 从光束发生器产生的离子束的行进通过，以控制离子束的范围;以及照射控制器，用于根据范围调制轮的旋转相位控制光束发生器的光束产生和加速操作。

公开(公告)号：US20070228291A1

公开(公告)日：2007-10-04

申请号：US11758755

申请日：2007-06-06

申请人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred Smith ,  Wayne Newhauser

发明人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred Smith ,  Wayne Newhauser

IPC分类号： A61N5/01

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K5/04 ,  H05H7/04

摘要： The invention is intended to increase the number of patients treatable using one wheel having a thickness varied in the rotating direction to change energy of an ion beam passing the wheel. Ion beam delivery equipment for irradiating an ion beam to a patient for treatment comprises a beam generator for producing and accelerating the ion beam, an beam delivery nozzle including a range modulation wheel which has a predetermined thickness distribution in the rotating direction and is rotated on a travel passage of the ion beam generated from the beam generator to control a range of the ion beam, and an irradiation controller for controlling the beam producing and accelerating operation of the beam generator in accordance with the phase of rotation of the range modulation wheel.

摘要翻译： 本发明旨在增加使用具有在旋转方向上变化的厚度的一个车轮来治疗的患者数量，以改变通过车轮的离子束的能量。 用于将离子束照射到患者进行治疗的离子束输送设备包括用于产生和加速离子束的束发生器，包括在旋转方向上具有预定厚度分布并在旋转方向上旋转的范围调制轮的束输送喷嘴 从光束发生器产生的离子束的行进通过，以控制离子束的范围;以及照射控制器，用于根据范围调制轮的旋转相位控制光束发生器的光束产生和加速操作。

公开(公告)号：US20060163496A1

公开(公告)日：2006-07-27

申请号：US11039960

申请日：2005-01-24

申请人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred Smith ,  Wayne Newhauser

发明人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred Smith ,  Wayne Newhauser

IPC分类号： A61N5/10

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K5/04 ,  H05H7/04

摘要： The invention is intended to increase the number of patients treatable using one wheel having a thickness varied in the rotating direction to change energy of an ion beam passing the wheel. Ion beam delivery equipment for irradiating an ion beam to a patient for treatment comprises a beam generator for producing and accelerating the ion beam, an beam delivery nozzle including a range modulation wheel which has a predetermined thickness distribution in the rotating direction and is rotated on a travel passage of the ion beam generated from the beam generator to control a range of the ion beam, and an irradiation controller for controlling the beam producing and accelerating operation of the beam generator in accordance with the phase of rotation of the range modulation wheel.

公开(公告)号：US07589334B2

公开(公告)日：2009-09-15

申请号：US11714219

申请日：2007-03-06

申请人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred Smith ,  Wayne Newhauser

发明人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred Smith ,  Wayne Newhauser

IPC分类号： G21G5/00

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K5/04 ,  H05H7/04

摘要： The invention is intended to increase the number of patients treatable using one wheel having a thickness varied in the rotating direction to change energy of an ion beam passing the wheel. Ion beam delivery equipment for irradiating an ion beam to a patient for treatment comprises a beam generator for producing and accelerating the ion beam, an beam delivery nozzle including a range modulation wheel which has a predetermined thickness distribution in the rotating direction and is rotated on a travel passage of the ion beam generated from the beam generator to control a range of the ion beam, and an irradiation controller for controlling the beam producing and accelerating operation of the beam generator in accordance with the phase of rotation of the range modulation wheel.

摘要翻译： 本发明旨在增加使用具有在旋转方向上变化的厚度的一个车轮来治疗的患者数量，以改变通过车轮的离子束的能量。 用于将离子束照射到患者进行治疗的离子束输送设备包括用于产生和加速离子束的束发生器，包括在旋转方向上具有预定厚度分布并在旋转方向上旋转的范围调制轮的束输送喷嘴 从光束发生器产生的离子束的行进通过，以控制离子束的范围;以及照射控制器，用于根据范围调制轮的旋转相位控制光束发生器的光束产生和加速操作。

公开(公告)号：US07576342B2

公开(公告)日：2009-08-18

申请号：US11758755

申请日：2007-06-06

申请人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred P. Smith ,  Wayne Newhauser

发明人： Kazuo Hiramoto ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Hisataka Fujimaki ,  Alfred P. Smith ,  Wayne Newhauser

IPC分类号： A61N5/01 ,  A61N5/00 ,  H01J37/08

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K5/04 ,  H05H7/04

摘要： The invention is intended to increase the number of patients treatable using one wheel having a thickness varied in the rotating direction to change energy of an ion beam passing the wheel. Ion beam delivery equipment for irradiating an ion beam to a patient for treatment comprises a beam generator for producing and accelerating the ion beam, an beam delivery nozzle including a range modulation wheel which has a predetermined thickness distribution in the rotating direction and is rotated on a travel passage of the ion beam generated from the beam generator to control a range of the ion beam, and an irradiation controller for controlling the beam producing and accelerating operation of the beam generator in accordance with the phase of rotation of the range modulation wheel.

摘要翻译： 本发明旨在增加使用具有在旋转方向上变化的厚度的一个车轮来治疗的患者数量，以改变通过车轮的离子束的能量。 用于将离子束照射到患者进行治疗的离子束输送设备包括用于产生和加速离子束的束发生器，包括在旋转方向上具有预定厚度分布并在旋转方向上旋转的范围调制轮的束输送喷嘴 从光束发生器产生的离子束的行进通过，以控制离子束的范围;以及照射控制器，用于根据范围调制轮的旋转相位控制光束发生器的光束产生和加速操作。

公开(公告)号：US20070252093A1

公开(公告)日：2007-11-01

申请号：US11414204

申请日：2006-05-01

申请人： Hisataka Fujimaki ,  Koji Matsuda ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Alfred Smith ,  Kazuo Hiramoto

发明人： Hisataka Fujimaki ,  Koji Matsuda ,  Hiroshi Akiyama ,  Masaki Yanagisawa ,  Alfred Smith ,  Kazuo Hiramoto

IPC分类号： G21K1/10 ,  A61N5/10

CPC分类号： A61N5/1048 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/10 ,  G21K5/04

摘要： The invention is intended to confirm whether the SOBP (spread-out Bragg peak) width is a desired value in real time during beam irradiation, and to improve safety in treatment. Ion beam delivery equipment comprises a beam generator including a synchrotron, an RMW (range modulation wheel) device for forming an SOBP width of an ion beam extracted from the beam generator, a beam delivery nozzle including a reference dose monitor and a main dose monitor which are installed respectively upstream and downstream of the RMW device in the direction of travel of the ion beam, and an SOBP width computing unit for computing the SOBP width of the ion beam, which is formed by the RMW device, based on values detected by both the reference dose monitor and the main dose monitor.

摘要翻译： 本发明旨在确认在光束照射期间SOBP（展​​开布拉格峰）宽度是否是实时的期望值，并且提高了处理中的安全性。 离子束输送设备包括一个光束发生器，它包括同步加速器，用于形成从光束发生器提取的离子束的SOBP宽度的RMW（范围调制轮）装置，包括参考剂量监测器和主剂量监测器 分别安装在RMW装置的上游和下游沿着离子束行进的方向;以及SOBP宽度计算单元，用于根据由两个检测到的值计算由RMW装置形成的离子束的SOBP宽度 参考剂量监测仪和主剂量监测仪。