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1.发明授权公开(公告)号：US06936707B2
公开(公告)日：2005-08-30
申请号：US09901572
申请日：2001-07-11
申请人： Takashi Okuda , Shuji Saito , Kristi M. Moore , Yoshinari Tsuzaki
发明人： Takashi Okuda , Shuji Saito , Kristi M. Moore , Yoshinari Tsuzaki
IPC分类号： C07K14/055 , C07K14/30 , C12N1/21 , C12N7/01 , C12N15/863 , C07H21/00 , A61K39/02 , C12N15/11 , C12N15/31 , C12N15/79
CPC分类号： C12N15/86 , C07K14/005 , C07K14/30 , C07K2319/00 , C07K2319/02 , C12N2710/16322 , C12N2710/24143
摘要： There is provided a DNA molecule derived from a prokaryotic cell in which at least one of the DNA regions encoding NXB (N is asparagine, X is any amino acid other than proline, and B is serine or threonine) has been modified so that no N-glycosylation occurs during the expression in a eukaryotic cell, and since the DNA molecule has been modified at the N-glycosylation site, it produces a non-N-glycosylated protein, which thereby exhibits a high immunogenicity when, for example, it is allowed to produce, in a eukaryotic cell, an antigen protein derived from a prokaryotic cell.
摘要翻译： 提供了衍生自原核细胞的DNA分子，其中编码NXB（N为天冬酰胺，X为除脯氨酸以外的任何氨基酸，B为丝氨酸或苏氨酸）的DNA区域中的至少一个已被修饰，使得不存在N 在真核细胞中表达期间发生糖基化，并且由于DNA分子在N-糖基化位点被修饰，所以它产生非N-糖基化的蛋白质，从而当例如允许的时候表现出高的免疫原性 在真核细胞中产生源自原核细胞的抗原蛋白。
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公开(公告)号：US06312696B1
公开(公告)日：2001-11-06
申请号：US09242632
申请日：1999-02-19
申请人： Yoshinari Tsuzaki , Takashi Okuda
发明人： Yoshinari Tsuzaki , Takashi Okuda
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16022 , Y10S424/816
摘要： The present invention discloses a DNA molecule that encodes a polypeptide that has the amino acid sequence described in SEQ ID No. 2 or an amino acid sequence that is at least 80% homologous with said amino acid sequence, a recombinant containing said DNA molecule, and a vaccine having for its active ingredient said recombinant.
摘要翻译： 本发明公开了一种DNA分子，其编码具有SEQ ID No.2所示氨基酸序列的多肽或与所述氨基酸序列至少80％同源的氨基酸序列，含有所述DNA分子的重组体，和 具有其活性成分的疫苗表示重组体。
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3.发明授权Fused protein, gene therefor, recombinant vector, recombinant virus, and its use 有权融合蛋白，其基因，重组载体，重组病毒及其用途公开(公告)号：US07348422B2
公开(公告)日：2008-03-25
申请号：US09147052
申请日：1997-03-28
申请人： Shuji Saitoh , Yoshinari Tsuzaki , Noboru Yanagida
发明人： Shuji Saitoh , Yoshinari Tsuzaki , Noboru Yanagida
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C07K14/30 , C07K2319/00 , C07K2319/02 , C12N2710/16322 , C12N2710/16622 , C12N2710/24043
摘要： A DNA coding for a fusion protein comprising a polypeptide having the antigenicity of Mycoplasma gallisepticum and a polypeptide derived from Herpesvirus outer membrane protein, in which the polypeptide derived from the outer membrane protein has been ligated with the polypeptide having the antigenicity of Mycoplasma gallisepticum at the N terminus thereof, is prepared. The DNA is inserted into a region non-essential to growth of Avipox virus and the resulting recombinant Avipox virus is provided as a more potent recombinant virus as an anti-Mycoplasma vaccine.
摘要翻译： 编码融合蛋白的DNA，其包含具有抗胆碱性支原体支原体的多肽和源自疱疹病毒外膜蛋白的多肽，其中来源于外膜蛋白的多肽已经与具有抗原性的鸡血清支原体的多肽连接 N末端。 将DNA插入到Avipox病毒的生长非必需区域中，并将得到的重组Avipox病毒作为更有效的重组病毒作为抗支原体疫苗提供。
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公开(公告)号：US07153511B2
公开(公告)日：2006-12-26
申请号：US10832353
申请日：2004-04-27
IPC分类号： A61K39/12
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5256 , A61K2039/55 , A61K2039/552 , C12N2710/16321 , C12N2720/10034 , Y10S424/816
摘要： The present invention provides an avian recombinant herpesvirus modified by the presence of the cDNA encoding, the VP2 of the Delaware Variant E strain of IBDV, a subtype of IBDV serotype 1 strains. The present invention further provides an avian recombinant herpesvirus comprised of the VP2 gene of which the backbone virus is a Marek's disease vaccine strain, such as herpesvirus of turkeys. A poultry vaccine including the avian herpes recombinant virus described in the present invention can induce in chickens protective immunity against a variety of different subtypes of IBDV.
摘要翻译： 本发明提供了通过编码IBDV的Delaware变体E株的VP2，IBDV血清型1株亚型的cDNA的存在而修饰的禽重组疱疹病毒。 本发明还提供了由VP2基因组成的禽类重组疱疹病毒，其中主要病毒是马立克氏病疫苗株，例如火鸡疱疹病毒。 包括本发明中描述的禽疱疹重组病毒的家禽疫苗可诱导针对IBDV的各种不同亚型的鸡的保护性免疫。
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