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公开(公告)号：US20070194223A1
公开(公告)日：2007-08-23
申请号：US10592299
申请日：2005-05-17
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译： 用于飞行时间（TOF）质谱的方法和装置。 该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。 该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。 分析仪由多层叠环形电场组成，实现螺旋轨迹。
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公开(公告)号：US08237112B2
公开(公告)日：2012-08-07
申请号：US13028481
申请日：2011-02-16
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译： 用于飞行时间（TOF）质谱的方法和装置。 该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。 该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。 分析仪由多层叠环形电场组成，实现螺旋轨迹。
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公开(公告)号：US20090212208A1
公开(公告)日：2009-08-27
申请号：US12390710
申请日：2009-02-23
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译： 用于飞行时间（TOF）质谱的方法和装置。 该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。 该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。 分析仪由多层叠环形电场组成，实现螺旋轨迹。
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公开(公告)号：US07504620B2
公开(公告)日：2009-03-17
申请号：US10592299
申请日：2005-05-17
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
IPC分类号： H01J49/40
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译： 用于飞行时间（TOF）质谱的方法和装置。 该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。 该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。 分析仪由多层叠环形电场组成，实现螺旋轨迹。
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公开(公告)号：US20110133073A1
公开(公告)日：2011-06-09
申请号：US13028481
申请日：2011-02-16
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译： 用于飞行时间（TOF）质谱的方法和装置。 该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。 该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。 分析仪由多层叠环形电场组成，实现螺旋轨迹。
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公开(公告)号：US07910879B2
公开(公告)日：2011-03-22
申请号：US12390710
申请日：2009-02-23
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译： 用于飞行时间（TOF）质谱的方法和装置。 该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。 该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。 分析仪由多层叠环形电场组成，实现螺旋轨迹。
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公开(公告)号：US20050103992A1
公开(公告)日：2005-05-19
申请号：US10983571
申请日：2004-11-09
CPC分类号： H01J49/408 , H01J49/0027
摘要： The present invention provides a time of flight mass spectrometer having a spiral flight path, whose mass resolution can be appropriately changed with respect to the analysis object or other factor without any complicated alteration or addition of the mechanical construction. In a specific form of the invention, the mass spectrometer includes deflecting electrodes 20-23 located between semi-cylindrical electrodes 11 and 12 for making ions fly along a spiral path. The deflecting electrodes 20-23 generate deflecting electric fields for shifting the ions in the axial direction of the semi-cylindrical electrodes 11 and 12. The voltage applied to the deflecting electrodes 20-23 is changed according to the mass resolution required. The deflecting electric fields are generated or removed with the change of the voltage, which makes the ions fly either along a spiral path or in the same loop orbit. The flight distance of the ions can be controlled as desired by regulating the voltage so that the ions fly in the loop orbit an appropriate number of times. Thus, the mass resolution can be arbitrarily controlled.
摘要翻译： 本发明提供了具有螺旋飞行路径的飞行时间质谱仪，其质量分辨率可以相对于分析对象或其他因素适当地改变，而没有任何复杂的改变或添加机械结构。 在本发明的具体形式中，质谱仪包括位于半圆柱形电极11和12之间的偏转电极20-23，用于使离子沿着螺旋路线飞行。 偏转电极20-23产生用于使离子沿半圆柱形电极11和12的轴向移动的偏转电场。 施加到偏转电极20-23的电压根据所需的质量分辨率而改变。 随着电压的变化产生或去除偏转电场，这使得离子沿着螺旋路径或相同的环轨道飞行。 通过调节电压可以根据需要控制离子的飞行距离，使得离子在环轨道中飞行适当次数。 因此，质量分辨率可以任意控制。
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公开(公告)号：US20050194528A1
公开(公告)日：2005-09-08
申请号：US10929768
申请日：2004-08-31
CPC分类号： H01J49/408 , H01J49/406
摘要： A time of flight type mass spectrometer (TOF-MS) of the present invention includes: a flight space containing a loop orbit on which ions fly once or more than once; a flight controller for making ions of a same mass to charge ratio fly the loop orbit at several values of number of turns; a flight time measurer for measuring a length of flight time of the ions; and a processor for determining the mass to charge ratio of the ions based on a relationship between the value of number of turns and the length of flight time of the ions. The speed of ions flying a loop orbit depends on their mass to charge ratios. For ions of the same mass to charge ratio, the difference between the lengths of flight time of the ions flying the loop orbit N turns and of the ions flying the loop orbit N+1 turns depends on the speed of the ions, so that the difference depends on the mass to charge ratio of the ions. The difference in the length of flight time is unrelated to the variation in the starting time (jitter), variation in the detection timing (jitter), etc, so that the value of the mass to charge ratio can be precisely determined free from errors caused by such disturbing factors.
摘要翻译： 本发明的飞行时间型质谱仪（TOF-MS）包括：包含离子飞行一次或多次的循环轨道的飞行空间; 用于使相同质荷比的离子的飞行控制器以匝数的几个值飞行环路轨道; 用于测量离子的飞行时间长度的飞行时间测量器; 以及用于基于匝数与离子的飞行时间长度之间的关系来确定离子的质荷比的处理器。 飞行环路轨道的离子速度取决于其质荷比。 对于相同质荷比的离子，飞越环轨道N圈的离子的飞行时间长度和飞行环轨道N + 1圈的离子之间的差异取决于离子的速度，因此 差异取决于离子的质荷比。 飞行时间长度的差异与启动时间（抖动）的变化，检测定时（抖动）等的变化无关，从而可以精确地确定质荷比值，从而避免误差 受到这样的扰乱因素。
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公开(公告)号：US07227131B2
公开(公告)日：2007-06-05
申请号：US10929768
申请日：2004-08-31
IPC分类号： H01J49/40
CPC分类号： H01J49/408 , H01J49/406
摘要： A time of flight type mass spectrometer (TOF-MS) of the present invention includes: a flight space containing a loop orbit on which ions fly once or more than once; a flight controller for making ions of a same mass to charge ratio fly the loop orbit at several values of number of turns; a flight time measurer for measuring a length of flight time of the ions; and a processor for determining the mass to charge ratio of the ions based on a relationship between the value of number of turns and the length of flight time of the ions. The speed of ions flying a loop orbit depends on their mass to charge ratios. For ions of the same mass to charge ratio, the difference between the lengths of flight time of the ions flying the loop orbit N turns and of the ions flying the loop orbit N+1 turns depends on the speed of the ions, so that the difference depends on the mass to charge ratio of the ions. The difference in the length of flight time is unrelated to the variation in the starting time (jitter), variation in the detection timing (jitter), etc, so that the value of the mass to charge ratio can be precisely determined free from errors caused by such disturbing factors.
摘要翻译： 本发明的飞行时间型质谱仪（TOF-MS）包括：包含离子飞行一次或多次的循环轨道的飞行空间; 用于使相同质荷比的离子的飞行控制器以匝数的几个值飞行环路轨道; 用于测量离子的飞行时间长度的飞行时间测量器; 以及用于基于匝数与离子的飞行时间长度之间的关系来确定离子的质荷比的处理器。 飞行环路轨道的离子速度取决于其质荷比。 对于相同质荷比的离子，飞越环轨道N圈的离子的飞行时间长度和飞行环轨道N + 1圈的离子之间的差异取决于离子的速度，因此 差异取决于离子的质荷比。 飞行时间长度的差异与启动时间（抖动）的变化，检测定时（抖动）等的变化无关，从而可以精确地确定质荷比值，从而避免误差 受到这样的扰乱因素。
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公开(公告)号：US07211792B2
公开(公告)日：2007-05-01
申请号：US11032002
申请日：2005-01-11
CPC分类号： H01J49/408
摘要： In the mass spectrometer of the present invention, a flight space is provided before the mass analyzer, and the flight space includes a loop orbit on which ions fly repeatedly. While ions fly on the loop orbit repeatedly, ion selecting electrodes placed on the loop orbit selects object ions having a specific mass to charge ratio in such a manner that, for a limited time period when the object ions are flying through the ion selecting electrodes, an appropriate voltage is applied to the ion selecting electrodes to make them continue to fly on the loop orbit, but otherwise to make or let other ions deflect from the loop orbit. If ions having various mass to charge ratios are introduced in the loop orbit almost at the same time, the object ions having the same mass to charge ratio continue to fly on the loop orbit in a band, but ions having mass to charge ratios different from that are separated from the object ions while flying on the loop orbit repeatedly. Even if the difference in the mass to charge ratio is small, the separation becomes large when the number of turns of the flight becomes large. After such a separation is adequately achieved, the ion selecting electrodes can select the object ions with high selectivity, or at high mass resolution. By adding dissociating means, fragment ions originated only from the selected object ions can be analyzed, which enables the identification and structural analysis of the sample at high accuracy.
摘要翻译： 在本发明的质谱仪中，在质量分析器之前提供飞行空间，并且飞行空间包括离子重复飞行的环轨道。 当离子重复地在环路轨道上飞行时，放置在环路轨道上的离子选择电极以这样的方式选择具有特定质荷比的物体离子，使得在物体离子飞过离子选择电极的有限时间段内， 对离子选择电极施加适当的电压使它们继续在环轨道上飞行，而另外使其它离子从环轨道偏转。 如果几乎同时在环路轨道中引入具有各种质荷比的离子，则具有相同质荷比的物体离子在带内的环路轨道上继续飞行，但质量与电荷比的离子不同于 它们与物体离子分离，同时在环路轨道上重复飞行。 即使质荷比的差小，当飞行匝数变大时，分离也变大。 在这种分离充分实现之后，离子选择电极可以以高选择性或高质量分辨率选择目标离子。 通过添加解离手段，可以分析仅从所选择的对象离子产生的碎片离子，这使得能够高精度地鉴定和结构分析样品。
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