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    Radioactive Diagnostic Imaging Agent
    1.
    发明申请
    Radioactive Diagnostic Imaging Agent 审中-公开
    放射诊断成像剂

    公开(公告)号：US20080193379A1

    公开(公告)日：2008-08-14

    申请号：US11921139

    申请日：2006-06-08

    申请人： Takayuki Shimada ,  Akira Nakatani ,  Keietsu Takahashi

    发明人： Takayuki Shimada ,  Akira Nakatani ,  Keietsu Takahashi

    IPC分类号： A61K51/04

    CPC分类号： A61K51/0491 ,  C07H5/02

    摘要： It is intended to provide a radioactive diagnostic imaging agent comprising a radioactive halogen-labeled compound as an active ingredient, in which the active ingredient is prevented from radiolysis and its stability is improved. This is achieved by adding a biologically-acceptable sugar or sugar alcohol to the radioactive diagnostic imaging agent in an amount effective to prevent radiolysis. The amount of the sugar or sugar alcohol to be added is preferably 10 (mmol/L)/GBq/mL or more, and more preferably 50 (mmol/L)/GBq/mL or more. The sugar is preferably selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, galactose, talose, erythrulose, ribulose, xylulose, psicose, fructose, sorbose, and tagatose. The sugar alcohol is preferably selected from the group consisting of erythritol, xylitol, sorbitol, and mannitol.

    摘要翻译： 旨在提供一种放射性诊断显像剂，其包含放射性卤素标记的化合物作为活性成分，其中防止活性成分进行放射分解并提高其稳定性。 这通过向放射性诊断显像剂中加入生物学上可接受的糖或糖醇来达到，其量可以有效地防止放射分解。 糖或糖醇的添加量优选为10（mmol / L）/ GBq / mL以上，更优选为50（mmol / L）/ GBq / mL以上。 优选选自赤藓糖，苏糖，核糖，阿拉伯糖，木糖，赖索糖，阿洛糖，阿卓糖，葡萄糖，甘露糖，古洛糖，艾多糖，半乳糖，托洛糖，赤藓糖，核酮糖，木酮糖，木糖，果糖，山梨糖， 和塔格糖。 糖醇优选选自赤藓糖醇，木糖醇，山梨糖醇和甘露糖醇。

    Radioactive diagnostic agent
    3.
    发明授权
    Radioactive diagnostic agent 失效
    放射性诊断剂

    公开(公告)号：US4666697A

    公开(公告)日：1987-05-19

    申请号：US558333

    申请日：1983-12-05

    申请人： Keietsu Takahashi ,  Nobuo Ueda ,  Masaaki Hazue

    发明人： Keietsu Takahashi ,  Nobuo Ueda ,  Masaaki Hazue

    IPC分类号： A61K51/00 ,  A61K47/48 ,  A61K51/08 ,  A61K51/10 ,  A61K43/00 ,  A61K49/00

    CPC分类号： A61K47/4823 ,  A61K51/088 ,  A61K51/1093 ,  A61K2123/00

    摘要： A radioactive diagnostic agent which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound a methyleneimine linkage (--CH.dbd.N--) or a methyleneamine linkage (--.sub.2 NH--) formed by the condensation between the formyl group in the polyformyl compound and the amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneimine linkage or a methyleneamine linkage formed by the condensation between the formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction, and (4) at least two radioactive metallic elements of which each is bonded to the chelating compound through a chelating bond.

    摘要翻译： 一种放射性诊断剂，其包含（1）每分子具有至少三个甲酰基的聚甲基化合物的单元，（2）至少两个与所述聚甲基化合物结合的含氨基的螯合化合物的单元，亚甲基亚胺键（-CH = N-）或通过聚甲酰基化合物中的甲酰基与螯合化合物中的氨基之间的缩合形成的亚甲基胺键（-2NH-），任选地随后还原，（3）至少一个氨基单元 通过由聚甲酰基化合物中的甲酰基与生理活性物质中的氨基之间的缩合形成的亚甲基亚胺键或亚甲基键连接到聚甲基化合物上的生理活性物质，任选地随后还原，和（4）在 至少两个放射性金属元素各自通过螯合键与螯合化合物结合。

    Chemical product usable as a non-radioactive carrier
    6.
    发明授权
    Chemical product usable as a non-radioactive carrier 失效
    可用作非放射性载体的化学产品

    公开(公告)号：US5077389A

    公开(公告)日：1991-12-31

    申请号：US947093

    申请日：1986-12-29

    申请人： Keietsu Takahashi ,  Nobuo Ueda ,  Masaaki Hazue

    发明人： Keietsu Takahashi ,  Nobuo Ueda ,  Masaaki Hazue

    IPC分类号： A61K51/00 ,  A61K47/48 ,  A61K51/08 ,  A61K51/10

    CPC分类号： A61K47/4823 ,  A61K51/088 ,  A61K51/1093 ,  A61K2123/00

    摘要： The present invention relates to a chemical product usable as a non-radioactive carrier which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound by a methyleneimine linkage (--CH.dbd.N--) or a methyleneamine linkage (--CH.sub.2 NH--) between a formyl group in the polyformy compound and an amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound by a methyleneimine linkage or a methyleneamine linkage between a formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction.

    Chemical product usable as a non-radioactive carrier
    7.
    发明授权
    Chemical product usable as a non-radioactive carrier 失效
    可用作非放射性载体的化学产品

    公开(公告)号：US5384401A

    公开(公告)日：1995-01-24

    申请号：US215671

    申请日：1994-03-22

    申请人： Keietsu Takahashi ,  Nobuo Ueda ,  Masaaki Hazue

    发明人： Keietsu Takahashi ,  Nobuo Ueda ,  Masaaki Hazue

    IPC分类号： A61K51/00 ,  A61K47/48 ,  A61K51/08 ,  A61K51/10 ,  C08B31/00 ,  C07C233/00 ,  C07C317/02 ,  C08B37/02 ,  C08F16/34

    CPC分类号： A61K47/4823 ,  A61K51/088 ,  A61K51/1093 ,  A61K2123/00

    摘要： A radioactive diagnostic agent which comprises (1) the unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound with intervention of a methyleneimine linkage (--CH.dbd.N--) or a methyleneamine linkage (--CH.sub.2 NH--) formed by the condensation between the formyl group in the polyformyl compound and the amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound with intervention of a methyleneimine linkage or a methyleneamine linkage formed by the condensation between the formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction, and (4) at least two radioactive metallic elements of which each is bonded to the chelating compound through a chelating bond.

    摘要翻译： 一种放射性诊断剂，其包含（1）每分子具有至少三个甲酰基的聚甲基化合物的单元，（2）至少两个与聚甲酰基化合物结合的含氨基的螯合化合物的单元， （-CH = N-）或通过聚甲酰基化合物中的甲酰基与螯合化合物中的氨基之间的缩合形成的亚甲基胺键（-CH 2 NH-），任选地随后还原，（3）至少一个单元 与聚甲酰基化合物结合的含氨基的生理活性物质通过由聚甲酰基化合物中的甲酰基与生理活性物质中的氨基之间的缩合形成的亚甲基亚胺键或亚甲基胺键介导，任选地随后还原， 和（4）至少两个放射性金属元素，其各自通过螯合键与螯合化合物键合。

    High molecular compounds having amino groups, and their utilization
    8.
    发明授权
    High molecular compounds having amino groups, and their utilization 失效
    具有氨基的高分子化合物及其利用

    公开(公告)号：US4855353A

    公开(公告)日：1989-08-08

    申请号：US15633

    申请日：1987-02-17

    申请人： Miki Kurami ,  Yoshifumi Shirakami ,  Keietsu Takahashi ,  Nobuo Ueda

    发明人： Miki Kurami ,  Yoshifumi Shirakami ,  Keietsu Takahashi ,  Nobuo Ueda

    IPC分类号： A61K47/48 ,  A61K51/06 ,  A61K51/10

    CPC分类号： A61K47/48692 ,  A61K47/48192 ,  A61K47/48315 ,  A61K51/065 ,  A61K51/1093 ,  A61K2121/00 ,  A61K2123/00 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/816

    摘要： A radioactive diagnostic or therapeutic agent, which comprises a metallic element-labeled high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group, at least one unit of (3) a physiologically active substance and (4) at least two radioactive metallic elements, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1) and each of the radioactive metallic element (4) being chelate-bonded to the chelate-forming compound (2).

    摘要翻译： 一种放射性诊断或治疗剂，其包含金属元素标记的高分子化合物，其包含一个单位的（1）每分子侧链具有至少三个氨基的多胺化合物，至少两个单位的（2） 具有羧基的螯合形成化合物，（3）生理活性物质和（4）至少两个放射性金属元素，螯合形成化合物（2）和生理活性物质（3）的至少一个单元 ）与多胺化合物（1）的侧链中的任何氨基结合，并且每个放射性金属元素（4）与螯合形成化合物（2）螯合。