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1.发明申请Organic metal compound and process for preparing optically-active alcohols using the same 审中-公开有机金属化合物及使用其制备光学活性醇的方法公开(公告)号：US20100069683A1
公开(公告)日：2010-03-18
申请号：US12583943
申请日：2009-08-28
申请人： Takashi Miki , Junichi Hori , Toshihide Takemoto , Noriyuki Utsumi , Takeaki Katayama , Masahito Watanabe , Kunihiko Murata
发明人： Takashi Miki , Junichi Hori , Toshihide Takemoto , Noriyuki Utsumi , Takeaki Katayama , Masahito Watanabe , Kunihiko Murata
IPC分类号： C07C37/00
CPC分类号： C07B53/00 , B01J31/1805 , B01J31/2295 , B01J2231/643 , B01J2531/0238 , B01J2531/822 , B01J2531/827 , C07F17/02
摘要： The present invention provides an asymmetric reduction catalyst effective in preparing optically-active alcohol compounds having various functional groups, and a process for preparing optically-active alcohol compounds using said asymmetric reduction catalyst.The organic metal compound of the present invention is represented by the following general formula (1): wherein R1 and R2 may be mutually identical or different, and are an alkyl group, a phenyl group, a naphthyl group, a cycloalkyl group, or an alicyclic ring formed by binding R1 and R2, which may have a substituent; R3 is a hydrogen atom or an alkyl group; Cp is a cyclopentadienyl group, which may have a substituent, bound to M1 via a π bond; X1 is a halogen atom or a hydrido group; M1 is rhodium or iridium; and * denotes asymmetric carbon.
摘要翻译： 本发明提供了一种有效地制备具有各种官能团的光学活性醇化合物的不对称还原催化剂，以及使用该不对称还原催化剂制备光学活性醇化合物的方法。 本发明的有机金属化合物由以下通式（1）表示：其中R1和R2可以相同或不同，为烷基，苯基，萘基，环烷基或 通过结合可以具有取代基的R 1和R 2形成的脂环; R3是氢原子或烷基; Cp是可以具有取代基的环戊二烯基，其通过a和p结合到M1; 键; X1是卤原子或氢环; M1是铑或铱; 和*表示不对称碳。
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公开(公告)号：US20090216019A1
公开(公告)日：2009-08-27
申请号：US11887340
申请日：2005-03-30
申请人： Ryoji Noyori , Takeshi Okuma , Kunihiko Tsutsumi , Nariyuki Utsumi , Kunihiko Murata , Takeaki Katayama
发明人： Ryoji Noyori , Takeshi Okuma , Kunihiko Tsutsumi , Nariyuki Utsumi , Kunihiko Murata , Takeaki Katayama
IPC分类号： C07F15/00 , C07D453/02
CPC分类号： C07F9/5027 , B01J31/1815 , B01J31/182 , B01J31/24 , B01J2231/643 , B01J2531/821 , C07B53/00 , C07D453/02 , C07F15/0046 , C07F15/0053
摘要： A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.
摘要翻译： 一种新型的钌络合物，其是用于制备光学活性3-奎宁环的高效催化剂，以及使用钌络合物作为催化剂生产光学活性3-奎宁环的方法，其中光学活性3-奎宁环醇可用作 用于药物和农药的光学活性的生理活性化合物或作为液晶材料的合成中间体。
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3.发明申请Organic metal compound and process for preparing optically-active alcohols using the same 审中-公开有机金属化合物及使用其制备光学活性醇的方法公开(公告)号：US20090062573A1
公开(公告)日：2009-03-05
申请号：US12218874
申请日：2008-07-18
申请人： Takashi Miki , Junichi Hori , Toshihide Takemoto , Noriyuki Utsumi , Takeaki Katayama , Masahito Watanabe , Kunihiko Murata
发明人： Takashi Miki , Junichi Hori , Toshihide Takemoto , Noriyuki Utsumi , Takeaki Katayama , Masahito Watanabe , Kunihiko Murata
IPC分类号： C07F15/00 , C07C29/143 , C07C37/00
CPC分类号： C07B53/00 , B01J31/1805 , B01J31/2295 , B01J2231/643 , B01J2531/0238 , B01J2531/822 , B01J2531/827 , C07F17/02
摘要： The present invention provides an asymmetric reduction catalyst effective in preparing optically-active alcohol compounds having various functional groups, and a process for preparing optically-active alcohol compounds using said asymmetric reduction catalyst.The organic metal compound of the present invention is represented by the following general formula (1): wherein R1 and R2 may be mutually identical or different, and are an alkyl group, a phenyl group, a naphthyl group, a cycloalkyl group, or an alicyclic ring formed by binding R1 and R2, which may have a substituent; R3 is a hydrogen atom or an alkyl group; Cp is a cyclopentadienyl group, which may have a substituent, bound to M1 via a π bond; X1 is a halogen atom or a hydrido group; M1 is rhodium or iridium; and * denotes asymmetric carbon.
摘要翻译： 本发明提供了一种有效地制备具有各种官能团的光学活性醇化合物的不对称还原催化剂，以及使用该不对称还原催化剂制备光学活性醇化合物的方法。 本发明的有机金属化合物由以下通式（1）表示：其中R1和R2可以相同或不同，为烷基，苯基，萘基，环烷基或 通过结合可以具有取代基的R 1和R 2形成的脂环; R3是氢原子或烷基; Cp是可以具有取代基的环戊二烯基，其通过π键与M1结合; X1是卤原子或氢环; M1是铑或铱; 和*表示不对称碳。
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4.发明授权公开(公告)号：US07601667B2
公开(公告)日：2009-10-13
申请号：US11922409
申请日：2006-03-10
申请人： Noriyuki Utsumi , Kunihiko Murata , Kunihiko Tsutsumi , Takeaki Katayama , Masahito Watanabe , Takeshi Ohkuma , Ryoji Noyori
发明人： Noriyuki Utsumi , Kunihiko Murata , Kunihiko Tsutsumi , Takeaki Katayama , Masahito Watanabe , Takeshi Ohkuma , Ryoji Noyori
IPC分类号： B01J31/18 , B01J31/12 , C07C29/145
CPC分类号： C07C311/18 , B01J31/1805 , B01J31/2204 , B01J31/2295 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B2200/07 , C07C29/145 , C07C2602/08 , C07D311/22 , C07C33/26 , C07C33/46 , C07C35/32
摘要： A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol.
摘要翻译： 将由下式表示的磺酸盐催化剂和酮化合物置于溶剂中，并且通过在氢气存在下混合来使酮化合物氢化以产生光学活性的醇。
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公开(公告)号：US20080234525A1
公开(公告)日：2008-09-25
申请号：US11922409
申请日：2006-03-10
申请人： Noriyuki Utsumi , Kunihiko Murata , Kunihiko Tsutsumi , Takeaki Katayama , Masahiro Watanabe , Takeshi Ohkuma , Ryoji Noyori
发明人： Noriyuki Utsumi , Kunihiko Murata , Kunihiko Tsutsumi , Takeaki Katayama , Masahiro Watanabe , Takeshi Ohkuma , Ryoji Noyori
IPC分类号： C07C29/143 , C07F11/00
CPC分类号： C07C311/18 , B01J31/1805 , B01J31/2204 , B01J31/2295 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B2200/07 , C07C29/145 , C07C2602/08 , C07D311/22 , C07C33/26 , C07C33/46 , C07C35/32
摘要： A sulfonate catalyst represented by the formula below and a ketone compound are placed in a solvent, and the ketone compound is hydrogenated by mixing in the presence of hydrogen to produce an optically active alcohol.
摘要翻译： 将由下式表示的磺酸盐催化剂和酮化合物置于溶剂中，并且通过在氢气存在下混合来使酮化合物氢化以产生光学活性的醇。
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公开(公告)号：US20110319671A1
公开(公告)日：2011-12-29
申请号：US13170347
申请日：2011-06-28
IPC分类号： C07C29/143
CPC分类号： C07C29/143 , C07B2200/07 , C07C31/38
摘要： The problem to be resolved by the present invention is to provide a method for efficiently synthesizing optically active lower aliphatic alcohols that have difficulty in separation from organic solvents, without using a special reactor.The present invention relates to a method for producing an optically active aliphatic alcohol having a fluorine atom at α position, wherein an optically active alcohol is produced by reacting an aliphatic ketone having a fluorine atom at α position in water using a formate, under the presence of an asymmetric catalyst represented by general formula (1) and an acid.
摘要翻译： 本发明要解决的问题是提供一种高效合成难以与有机溶剂分离的光学活性低级脂族醇的方法，而不使用特殊的反应器。 本发明涉及一种在α位具有氟原子的光学活性脂肪醇的制造方法，其特征在于，在甲酸盐存在下，使甲酸酯在水中的α位置具有氟原子的脂肪族酮， 的由通式（1）表示的不对称催化剂和酸。
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公开(公告)号：US08558033B2
公开(公告)日：2013-10-15
申请号：US13170347
申请日：2011-06-28
IPC分类号： C07C29/143
CPC分类号： C07C29/143 , C07B2200/07 , C07C31/38
摘要： The problem to be resolved by the present invention is to provide a method for efficiently synthesizing optically active lower aliphatic alcohols that have difficulty in separation from organic solvents, without using a special reactor.The present invention relates to a method for producing an optically active aliphatic alcohol having a fluorine atom at α position, wherein an optically active alcohol is produced by reacting an aliphatic ketone having a fluorine atom at α position in water using a formate, under the presence of an asymmetric catalyst represented by general formula (1) and an acid.
摘要翻译： 本发明要解决的问题是提供一种高效合成难以与有机溶剂分离的光学活性低级脂族醇的方法，而不使用特殊的反应器。 本发明涉及一种在α位具有氟原子的光学活性脂族醇的制造方法，其中通过使甲酸钠在水中的α位具有氟原子的脂族酮与甲酸酯反应来制备光学活性醇， 的由通式（1）表示的不对称催化剂和酸。
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公开(公告)号：US08212037B2
公开(公告)日：2012-07-03
申请号：US11887340
申请日：2005-03-30
申请人： Ryoji Noyori , Takeshi Okuma , Kunihiko Tsutsumi , Noriyuki Utsumi , Kunihiko Murata , Takeaki Katayama
发明人： Ryoji Noyori , Takeshi Okuma , Kunihiko Tsutsumi , Noriyuki Utsumi , Kunihiko Murata , Takeaki Katayama
IPC分类号： C07F15/00 , C07D453/02
CPC分类号： C07F9/5027 , B01J31/1815 , B01J31/182 , B01J31/24 , B01J2231/643 , B01J2531/821 , C07B53/00 , C07D453/02 , C07F15/0046 , C07F15/0053
摘要： A novel ruthenium complex which is a highly efficient catalyst useful for the production of optically active 3-quinuclidinols, and a process for production of optically active 3-quinuclidinols using the ruthenium complex as a catalyst, where the optically active 3-quinuclidinols are useful as an optically active, physiologically active compound utilized in medicines and agrichemicals or as a synthetic intermediate such as a liquid crystal material.
摘要翻译： 一种新型的钌络合物，其是用于制备光学活性3-奎宁环的高效催化剂，以及使用钌络合物作为催化剂生产光学活性3-奎宁环的方法，其中光学活性3-奎宁环醇可用作 用于药物和农药的光学活性的生理活性化合物或作为液晶材料的合成中间体。
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9.发明授权Method for producing optically active quinuclidinols having one or more substituted groups at the 2-position 失效在2-位具有一个或多个取代基的光学活性奎宁环醇的制备方法公开(公告)号：US07687630B2
公开(公告)日：2010-03-30
申请号：US11906103
申请日：2007-09-28
申请人： Takeaki Katayama , Kunihiko Murata
发明人： Takeaki Katayama , Kunihiko Murata
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： The invention provides a method for producing optically active 3-quinuclidinols having one or more substituted groups at the 2-position; wherein 3-quinuclidinones having one or more substituted groups at the 2-position are reacted with compounds providing hydrogen in the presence of a certain metal complex.
摘要翻译： 本发明提供了在2-位具有一个或多个取代基的光学活性3-奎宁环醇的制备方法; 其中在2-位具有一个或多个取代基的3-奎宁环酮与在某种金属络合物存在下提供氢的化合物反应。
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10.发明申请Method for producing optically active quinuclidinols having one or more substituted groups at the 2-position 失效在2-位具有一个或多个取代基的光学活性奎宁环醇的制备方法公开(公告)号：US20080081911A1
公开(公告)日：2008-04-03
申请号：US11906103
申请日：2007-09-28
申请人： Takeaki Katayama , Kunihiko Murata
发明人： Takeaki Katayama , Kunihiko Murata
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： The invention provides a method for producing optically active 3-quinuclidinols having one or more substituted groups at the 2-position; wherein 3-quinuclidinones having one or more substituted groups at the 2-position are reacted with compounds providing hydrogen in the presence of a certain metal complex.
摘要翻译： 本发明提供了在2-位具有一个或多个取代基的光学活性3-奎宁环醇的制备方法; 其中在2-位具有一个或多个取代基的3-奎宁环酮与在某种金属络合物存在下提供氢的化合物反应。
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