公开(公告)号：US07138490B2

公开(公告)日：2006-11-21

申请号：US10481347

申请日：2002-06-19

申请人： Takeshi Nakanishi ,  Kazuhisa Shimizu ,  Ryuji Uehara ,  Masanobu Suzuki

发明人： Takeshi Nakanishi ,  Kazuhisa Shimizu ,  Ryuji Uehara ,  Masanobu Suzuki

IPC分类号： C07K1/107 ,  C07K1/00 ,  C07K1/14 ,  C07K2/00 ,  A61K38/00 ,  A61K38/02

CPC分类号： A61K31/704 ,  A61K47/645

摘要： A process for purification which permits satisfactory removal of impurities from a block copolymer consisting essentially of polyethylene glycols and poly(acidic amino acid) and is suitable for the production of a polymeric carrier having a pharmaceutically acceptable purity; a process for producing such a polymeric carrier; a block copolymer reduced in impurity content; a polymeric carrier as described above; pharmaceutical preparations in polymeric form, produced by the use of the carrier; and a method of subjecting polyethylene glycols and poly(acidic amino acids)—which are impurities contained in the block copolymer—to treatment with either an ion-exchange resin or a partition/absorption resin and then determining the quantities of them with a gel filtration column.

摘要翻译： 一种纯化方法，其允许从基本上由聚乙二醇和聚（酸性氨基酸）组成的嵌段共聚物中令人满意地除去杂质，并且适用于生产具有药学上可接受的纯度的聚合物载体; 制备这种聚合物载体的方法; 嵌段共聚物杂质含量降低; 如上所述的聚合物载体; 通过使用载体生产的聚合物形式的药物制剂; 和使用嵌段共聚物中含有的杂质的聚乙二醇和聚（酸性氨基酸）与离子交换树脂或分隔/吸收树脂一起处理，然后用凝胶过滤法测定它们的量 柱。

公开(公告)号：US6080396A

公开(公告)日：2000-06-27

申请号：US836965

申请日：1997-08-18

申请人： Masayuki Yokoyama ,  Kazunori Kataoka ,  Teruo Okano ,  Yasuhisa Sakurai ,  Shigeto Fukushima ,  Ryuji Uehara ,  Tomoko Akutsu ,  Kazuya Okamoto ,  Hiroko Mashiba ,  Megumi Machida ,  Kazuhisa Shimizu

发明人： Masayuki Yokoyama ,  Kazunori Kataoka ,  Teruo Okano ,  Yasuhisa Sakurai ,  Shigeto Fukushima ,  Ryuji Uehara ,  Tomoko Akutsu ,  Kazuya Okamoto ,  Hiroko Mashiba ,  Megumi Machida ,  Kazuhisa Shimizu

IPC分类号： A61K9/107 ,  A61K9/51 ,  A61K9/127 ,  A61K31/70 ,  C07M17/08

CPC分类号： A61K9/1075

摘要： A dimer, trimer or tetramer of an anthracycline compound which can be obtained by directly, chemically bonding anthracycline compounds having anticancer activities to each other by an alkali treatment. A high molecular block copolymer-drug complex pharmaceutical preparation in which the high molecular block copolymer having a hydrophilic polymer segment and a hydrophobic polymer segment forms a micelle having the hydrophilic segment as its outer shell and contains in its hydrophobic inner core a dimer, trimer or tetramer of anthracycline compound alone or together with other drugs. A high molecular block copolymer-drug complex pharmaceutical preparation in which the high molecular block copolymer having a hydrophilic polymer segment and a hydrophobic polymer segment forms a micelle having the hydrophilic segment as its outer shell and contains in its hydrophobic inner core an anthracycline anticancer agent, wherein, when the pharmaceutical preparation is intravenously administered to a CDF1 mouse, the amount of the anthracycline anticancer agent in 1 ml of the mouse blood plasma after 1 hour of its administration becomes 10 (% of dose/ml) or more, provided that the amount of anthracycline anticancer agent in the administered preparation is defined as 100. The aforementioned pharmaceutical preparations have high drug effects and low toxicities.

摘要翻译： PCT No.PCT / JP96 / 02789第 371日期：1997年8月18日 102（e）日期1997年8月18日PCT提交1996年9月26日PCT公布。 公开号WO97 / 12895 日期1997年04月10日可以通过碱处理直接化学键合具有抗癌活性的蒽环类化合物而获得的蒽环类化合物的二聚体，三聚体或四聚体。 一种高分子嵌段共聚物 - 药物复合药物制剂，其中具有亲水性聚合物链段和疏水性聚合物链段的高分子嵌段共聚物形成具有亲水链段作为其外壳的胶束，并且在其疏水内核中含有二聚体，三聚体或 蒽环类化合物的四聚体单独或与其他药物一起。 一种高分子嵌段共聚物 - 药物复合药物制剂，其中具有亲水性聚合物链段和疏水性聚合物链段的高分子嵌段共聚物形成具有亲水链段作为其外壳并在其疏水内核中含有蒽环类抗癌剂的胶束， 其中，当向CDF1小鼠静脉内施用药物制剂时，在施用1小时后1ml小鼠血浆中的蒽环类抗癌剂的量为10（％/剂量）以上，条件是 给药制剂中蒽环类抗癌剂的量定义为100.上述药物制剂具有高药物作用和低毒性。

公开(公告)号：US20080146692A1

公开(公告)日：2008-06-19

申请号：US11792605

申请日：2005-12-15

申请人： Ryuji Uehara ,  Ryutaro Tanaka

发明人： Ryuji Uehara ,  Ryutaro Tanaka

IPC分类号： C08G73/12 ,  C08F290/14

CPC分类号： G03F7/0387 ,  C08F290/14 ,  C08F290/145 ,  C08G73/1085 ,  G03F7/0388 ,  H05K1/0346 ,  H05K3/287 ,  H05K3/4676

摘要： The present invention provides a photosensitive resin which is rich in heat resistance and flexibility. The present invention relates to the unsaturated group-containing polyimide resin obtained through a reaction between a polyimide resin, which is obtained by polyimidization of a polyamide acid obtained through a reaction between a diamino-6-hydroxypyrimidine (diamine component (A)) and an aromatic tetrabasic acid dianhydride (C), and an unsaturated group-containing compound, preferably a compound having a reactive group such as an acid anhydride group or isocyanate group and an unsaturated group; relates to a photosensitive resin composition containing such resin, a crosslinking agent and photopolymerization initiator; and relates to a cured product of such a resin composition. The photosensitive resin composition containing such an unsaturated group-containing polyimide resin has good development characteristic and photosensitivity, and enables to form the polyimide resin cured film without requiring a heat treatment step. The cured film has flexibility and is excellent in solvent resistance as well.

摘要翻译： 本发明提供一种耐热性和柔软性高的感光性树脂。 本发明涉及通过由二氨基-6-羟基嘧啶（二胺成分（A））与二氨基-6-羟基嘧啶（二胺成分（A））的反应得到的聚酰胺酸的聚酰亚胺化反应得到的聚酰亚胺树脂之间的反应而得到的含不饱和基团的聚酰亚胺树脂， 芳族四元酸二酐（C）和含不饱和基团的化合物，优选具有酸酐基或异氰酸酯基等反应性基团的化合物和不饱和基团; 涉及含有这种树脂的光敏树脂组合物，交联剂和光聚合引发剂; 涉及这种树脂组合物的固化物。 含有这样的含不饱和基团的聚酰亚胺树脂的感光性树脂组合物具有良好的显影特性和光敏性，能够形成聚酰亚胺树脂固化膜而不需要热处理步骤。 固化膜具有柔软性，耐溶剂性也优异。