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1.发明申请公开(公告)号：US20130131320A1
公开(公告)日：2013-05-23
申请号：US13510516
申请日：2010-11-11
申请人： Izumi Kumagai , Takeshi Nakanishi , Ryutaro Asano , Mitsuo Umetsu
发明人： Izumi Kumagai , Takeshi Nakanishi , Ryutaro Asano , Mitsuo Umetsu
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , C07K16/2809 , C07K16/2863 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/92
摘要： [Problem]Disclosed is an antibody that exhibits excellent cytotoxicity and cell growth inhibition and that is based on an anti-human epithelial cell growth factor receptor (1) (Her1) antibody (528). Further disclosed is a method for producing same, and the like.[Solution]The mutant of an H chain humanized variable region (5H) or an L chain humanized variable region (5L) of the anti-human epithelial cell growth factor receptor (1) (Her1) antibody (528) is the aforementioned antibody characterized by having one to a plurality (for example: 1 to 5, or 1 to 3) of amino acid mutations within CDR2. Further disclosed are antibody molecules containing said region, a nucleic acid molecule coding for these polypeptides, a method for producing said antibody molecules, and the like.
摘要翻译： [问题]公开了一种表现出优异的细胞毒性和细胞生长抑制的抗体，其基于抗人上皮细胞生长因子受体（1）（Her1）抗体（528）。 进一步公开了其制造方法等。 [解决方案]抗人上皮细胞生长因子受体（1）（Her1）抗体（528）的H链人源化可变区（5H）或L链人源化可变区（5L）的突变体是上述抗体 通过在CDR2内具有1至多个（例如：1至5个，或1至3个）氨基酸突变。 进一步公开的是含有所述区域的抗体分子，编码这些多肽的核酸分子，产生所述抗体分子的方法等。
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公开(公告)号：US20050214375A1
公开(公告)日：2005-09-29
申请号：US10517729
申请日：2003-06-18
IPC分类号： A61K9/127 , A61K9/19 , A61K31/704 , A61K31/785 , A61K47/30 , A61K47/34 , A61K47/48 , A61P35/00 , C08G73/10 , C08L71/10 , A61K9/14
CPC分类号： A61K31/785 , A61K9/19 , A61K47/34 , A61K47/6907 , C08G73/1092 , C08L71/10 , C08L2666/20
摘要： A process for producing a block copolymer-drug composite that can be industrialized, wherein neither dialysis nor ultrafiltration is performed and wherein halogenated hydrocarbons are not used. The process for producing a block copolymer-drug composite is characterized by comprising the steps of dissolving an AB type block copolymer composed of hydrophilic polymer structure moiety and hydrophobic polyamino aid structure moiety together with a drug in water or a mixed solvent of water and a low-boiling-point organic solvent miscible with water and concentrating the resultant solution.
摘要翻译： 一种生产可工业化的嵌段共聚物 - 药物复合材料的方法，其中不进行透析或超滤，并且不使用卤代烃。 制备嵌段共聚物 - 药物复合材料的方法的特征在于包括以下步骤：将由亲水性聚合物结构部分组成的AB型嵌段共聚物和疏水性聚氨基辅助结构部分与药物溶解在水或水和低的混合溶剂中 沸点有机溶剂与水混溶并浓缩所得溶液。
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公开(公告)号：US4658413A
公开(公告)日：1987-04-14
申请号：US874472
申请日：1986-06-16
摘要： An X-ray imaging system which enables recording of an X-ray image of an object at a desired time without substantial delay while fluoroscopically observing the X-ray image with the eye, and in which the filament current of the X-ray tube is kept at a constant level at all times, and the tube voltage is supplied in synchronism with the vertical scanning of a TV camera in the form of pulses, the width of which is changed depending upon whether the X-ray image is fluoroscopically observed with the eye or a picture thereof is radiographically recorded.
摘要翻译： 一种X射线成像系统，其能够在利用眼睛荧光观察X射线图像的同时在期望的时间记录物体的X射线图像，而X射线管的细丝电流为 始终保持恒定水平，并且以脉冲形式的电视摄像机的垂直扫描同步地供给管电压，其宽度根据X射线图像是否被透视观察而改变 眼睛或其图片被放射摄影记录。
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公开(公告)号：US4019319A
公开(公告)日：1977-04-26
申请号：US604751
申请日：1975-08-14
CPC分类号： F02K9/62
摘要： High-pressure gas generating apparatus includes a gas generator body provided with a combustion chamber. The gas generator body has a primary propellant injector including orifices for injecting a primary fuel and orifices for injecting a primary oxidizing agent, both the orifices being open to the combustion chamber, an igniter for igniting the primary fuel forced out from the injector, and valve means having a secondary fuel injecting orifice for injecting a metal fuel into a high-temperature gas atmosphere to be reacted therewith and containing a secondary oxidizing agent produced by the reaction of the primary fuel injected from the primary propellant injector with the primary oxidizing agent similarly injected.
摘要翻译： 高压气体发生装置包括设置有燃烧室的气体发生器主体。 气体发生器主体具有主推进剂喷射器，其包括用于喷射初级燃料的喷嘴和用于喷射初级氧化剂的孔口，两个喷嘴都通向燃烧室，点火器用于点燃从喷射器排出的主要燃料，以及阀 具有用于将金属燃料注入到与其反应的高温气体气氛中的二次燃料喷射孔的装置，并且包含通过从主推进剂喷射器喷射的初级燃料与主氧化剂的反应产生的二次氧化剂， 。
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5.发明授权Fragment of humanized anti-EGFR antibody substituted-lysine variable fragment and use thereof 有权人源化抗EGFR抗体取代赖氨酸可变片段的片段及其用途公开(公告)号：US09139650B2
公开(公告)日：2015-09-22
申请号：US13816420
申请日：2011-07-16
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2317/626
摘要： The purpose of the present invention is to provide fragments of humanized anti-EGFR antibody substituted-lysine light-chain or heavy-chain variable regions, and single-chain antibodies, etc, comprising the same, having sufficient binding activity (affinity) with target cells, and having the ability to undergo various site-specific and uniform chemical modifications. The present invention pertains to a humanized variable region on the light-chain or heavy-chain of antibody 528 against human epidermal cell growth factor receptor 1 (Her-1), said variable region comprising the amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4, wherein fragments of humanized anti-EGFR antibody lysine-substituted light-chain variable regions are formed by substituting a different amino acid for all of the lysine residues, or all of the lysine residues except for the lysine residue(s) of one specified moiety.
摘要翻译： 本发明的目的是提供人源化抗EGFR抗体取代的赖氨酸轻链或重链可变区的片段，以及包含该片段的具有足够的与靶标结合活性（亲和力）的单链抗体 并且具有进行各种位点特异性和均匀化学修饰的能力。 本发明涉及针对人表皮细胞生长因子受体1（Her-1）的抗体528的轻链或重链上的人源化可变区，所述可变区包含SEQ ID NO：2所示的氨基酸序列 或SEQ ID NO：4，其中人源化抗EGFR抗体赖氨酸取代的轻链可变区的片段通过用不同的氨基酸取代所有赖氨酸残基或除赖氨酸残基之外的所有赖氨酸残基形成（ s）。
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公开(公告)号：US20110294980A1
公开(公告)日：2011-12-01
申请号：US12991041
申请日：2009-04-28
申请人： Takeshi Nakanishi , Kazuhisa Hara , Chieko Seno
发明人： Takeshi Nakanishi , Kazuhisa Hara , Chieko Seno
CPC分类号： A61K47/48315 , A61K31/785 , A61K47/34 , A61K47/60 , A61K47/645 , C08G69/10 , C08G69/40 , C08G69/48
摘要： Disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein an amide bond is not used. The compound has chemical stability and adequate drug release rate in the living organism. Specifically disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein a substituent represented by formula (I) is bonded to a carboxy group of a block copolymer which is composed of a polyethylene glycol and a polymer having a carboxy group in a side chain, or a pharmacologically acceptable salt thereof. [In the formula, A represents a monocyclic or fused aromatic group; G represents an optionally substituted (C1-C6) alkylene group; Y represents a hydrogen atom or a substituent; and E represents a residue of folic acid or a folic acid derivative.]
摘要翻译： 公开了叶酸或叶酸衍生物的聚合物缀合物，其中不使用酰胺键。 该化合物在生物体中具有化学稳定性和足够的药物释放速率。 具体公开的是叶酸或叶酸衍生物的聚合物缀合物，其中由式（I）表示的取代基与由聚乙二醇和具有羧基的聚合物组成的嵌段共聚物的羧基键合 侧链或其药理学上可接受的盐。 [式中，A表示单环或稠合芳基; G表示任选取代的（C 1 -C 6）亚烷基; Y表示氢原子或取代基; E表示叶酸或叶酸衍生物的残基。]
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公开(公告)号：US20090306002A1
公开(公告)日：2009-12-10
申请号：US12482723
申请日：2009-06-11
IPC分类号： A61K31/7004 , A61K31/194 , A61P7/00
CPC分类号： A61K31/194 , A61K9/0019
摘要： An acetic acid- and/or acetate salt-free iron metabolism-improving agent that contains citric acid and/or a citrate salt as electrolytes and also contains another/other electrolyte/electrolytes and glucose solely or in combination is provided. The iron metabolism-improving agent can be formulated into a dialysate and/or a substitution fluid. A method for improving internal iron metabolism and a blood purification method including hemodialysis and hemodiafiltration in a chronic renal failure patient employing the dialysate and/or the substitution fluid are further provided.
摘要翻译： 提供了含有柠檬酸和/或柠檬酸盐作为电解质并且还单独或组合地含有另一种/其它电解质/电解质和葡萄糖的不含乙酸和/或乙酸盐的铁代谢改善剂。 铁代谢改善剂可配制成透析液和/或置换液。 进一步提供一种用于改善内部铁代谢的方法和包括使用透析液和/或替代液体的慢性肾衰竭患者的血液透析和血液透析滤过的血液净化方法。
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8.发明授权Process for preparing benzo�c!phenanthridinium derivatives, novel compounds prepared by said process, and antitumor agents 失效制备苯并[c]菲啶鎓衍生物，通过所述方法制备的新化合物和抗肿瘤剂的方法
公开(公告)号：US5747502A
公开(公告)日：1998-05-05
申请号：US851853
申请日：1992-03-16
申请人： Miyoji Hanaoka , Hisao Ekimoto , Fumiko Kobayashi , Yukio Irie , Katsutoshi Takahashi , Masanobu Suzuki , Takeshi Nakanishi , Osamu Kogawa , Keizou Ishikawa
发明人： Miyoji Hanaoka , Hisao Ekimoto , Fumiko Kobayashi , Yukio Irie , Katsutoshi Takahashi , Masanobu Suzuki , Takeshi Nakanishi , Osamu Kogawa , Keizou Ishikawa
IPC分类号： A61K31/473 , A61K31/44 , C07D471/00
CPC分类号： A61K31/473 , Y10S514/883 , Y10S514/908
摘要： The present invention relates to benzo�c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.
摘要翻译： 本发明涉及通式A的苯并[c]菲啶鎓衍生物：其中M和N各自表示羟基或低级烷氧基，或M和N同时代表氢原子或一起形成亚甲二氧基 基团，X-表示酸残基或氢酸残基，R表示低级烷基，以及制备该衍生物的方法。 该化合物表现出有效的抗肿瘤活性和血小板聚集抑制活性，并且预期可用于治疗肿瘤。 该方法具有良好的再现性并且可以在中等条件下进行，因此该方法实际上是有用的。 此外，本发明化合物的氢盐具有增强的稳定性，这将其配制成药物制剂是有利的。
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公开(公告)号：US4755681A
公开(公告)日：1988-07-05
申请号：US913416
申请日：1986-09-29
申请人： Syotaro Oka , Motosada Kiri , Takeshi Nakanishi , Kenji Shibata
发明人： Syotaro Oka , Motosada Kiri , Takeshi Nakanishi , Kenji Shibata
CPC分类号： H04N3/1593 , H04N5/32
摘要： A radiation image detecting apparatus having its radiation image receiving plane divided into picture elements made up of a plurality of two-dimensionally arrayed unit radiation detectors and having its picture element image signal processing electronic circuits thereon in a plurality of IC packages.
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10.发明申请公开(公告)号：US20130274446A1
公开(公告)日：2013-10-17
申请号：US13816420
申请日：2011-07-16
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2317/626
摘要： The purpose of the present invention is to provide fragments of humanized anti-EGFR antibody substituted-lysine light-chain or heavy-chain variable regions, and single-chain antibodies, etc, comprising the same, having sufficient binding activity (affinity) with target cells, and having the ability to undergo various site-specific and uniform chemical modifications. The present invention pertains to a humanized variable region on the light-chain or heavy-chain of antibody 528 against human epidermal cell growth factor receptor 1 (Her-1), said variable region comprising the amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4, wherein fragments of humanized anti-EGFR antibody lysine-substituted light-chain variable regions are formed by substituting a different amino acid for all of the lysine residues, or all of the lysine residues except for the lysine residue(s) of one specified moiety.
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