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1.发明申请FUSED PYRIDAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT 审中-公开熔化的吡啶衍生物和含有这些化合物的药物作为活性成分公开(公告)号：US20080261947A1
公开(公告)日：2008-10-23
申请号：US12137267
申请日：2008-06-11
IPC分类号： A61K31/501 , C07D237/32 , C07D401/12 , C07D403/12 , A61K31/55 , A61P29/00 , A61P3/10 , A61P27/06 , A61P25/00 , A61P9/00 , C07D471/04 , C07D413/14 , A61K31/5377
CPC分类号： C07D403/06 , C07D237/26 , C07D237/32 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.). Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV etc.), sensitizers in treating cancer and immunosuppressants.
摘要翻译： 由式（I）表示的稠合哒嗪衍生物或其药学上可接受的盐（其中每个符号具有说明书中定义的含义）。 由于抑制聚（ADP-核糖）聚合酶，式（I）表示的化合物可用作各种缺血性疾病（脑，脐带，心脏，消化道，骨骼肌，视网膜等）的预防和/或补救措施， ，炎性疾病（炎性肠病，多发性脑血管病，关节炎等），神经变性疾病（锥体外系疾病，阿尔茨海默病，肌营养不良，腰椎管狭窄等），糖尿病，休克，头部创伤，肾衰竭，痛觉过敏， 此外，这些化合物可用作抗逆转录病毒（HIV等），敏化剂治疗癌症和免疫抑制剂的药剂。
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2.发明授权Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient 失效稠合的哒嗪衍生物化合物和含有这些化合物的药物作为活性成分公开(公告)号：US07402580B2
公开(公告)日：2008-07-22
申请号：US10505012
申请日：2003-02-18
IPC分类号： C07D403/12 , C07D405/12 , C07D237/32 , A61K31/502
CPC分类号： C07D403/06 , C07D237/26 , C07D237/32 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.). Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV etc.), sensitizers in treating cancer and immunosuppressants.
摘要翻译： 由式（I）表示的稠合哒嗪衍生物或其药学上可接受的盐（其中每个符号具有说明书中定义的含义）。 由于抑制聚（ADP-核糖）聚合酶，式（I）表示的化合物可用作各种缺血性疾病（脑，脐带，心脏，消化道，骨骼肌，视网膜等）的预防和/或补救措施， ，炎性疾病（炎性肠病，多发性脑血管病，关节炎等），神经变性疾病（锥体外系疾病，阿尔茨海默病，肌营养不良，腰椎管狭窄等），糖尿病，休克，头部创伤，肾衰竭，痛觉过敏， 此外，这些化合物可用作抗逆转录病毒（HIV等），敏化剂治疗癌症和免疫抑制剂的药剂。
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3.发明申请Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient 失效稠合的哒嗪衍生物化合物和含有这些化合物作为活性成分的药物公开(公告)号：US20050085476A1
公开(公告)日：2005-04-21
申请号：US10505012
申请日：2003-02-18
IPC分类号： A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/542 , A61K31/55 , A61K31/551 , A61K31/554 , A61P3/10 , A61P7/08 , A61P9/00 , A61P9/10 , A61P13/12 , A61P25/00 , A61P27/06 , A61P29/00 , A61P31/12 , A61P31/18 , A61P37/06 , A61P43/00 , C07D237/26 , C07D237/32 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04 , A61K31/503
CPC分类号： C07D403/06 , C07D237/26 , C07D237/32 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.). Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV etc.), sensitizers in treating cancer and immunosuppressants.
摘要翻译： 由式（I）表示的稠合哒嗪衍生物或其药学上可接受的盐（其中每个符号具有说明书中定义的含义）。 由于抑制聚（ADP-核糖）聚合酶，式（I）表示的化合物可用作各种缺血性疾病（脑，脐带，心脏，消化道，骨骼肌，视网膜等）的预防和/或补救措施， ，炎性疾病（炎性肠病，多发性脑血管病，关节炎等），神经变性疾病（锥体外系疾病，阿尔茨海默病，肌营养不良，腰椎管狭窄等），糖尿病，休克，头部创伤，肾衰竭，痛觉过敏， 此外，这些化合物可用作抗逆转录病毒（HIV等），敏化剂治疗癌症和免疫抑制剂的药剂。
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公开(公告)号：US20060058310A1
公开(公告)日：2006-03-16
申请号：US10534051
申请日：2003-11-13
IPC分类号： A61K31/517 , A61K31/498 , A61K31/4747 , A61K31/426 , A61K31/557
CPC分类号： A61K31/426 , A61K31/499 , A61K31/517
摘要： The present invention relates to a preventive and/or therapeutic agent for spinal canal stenosis comprising aldose reductase inhibitory compounds. A representative example of aldose reductase inhibitory compounds is the compound represented by formula (I): wherein all the symbols represent the same meaning as described in the specification; a salt of its acid when R3a represents hydrogen, or solvate thereof The therapeutic agent of the present invention is effective for prevention and/or therapy for spinal canal stenosis and the like, such as lumbar spinal canal stenosis.
摘要翻译： 本发明涉及包含醛糖还原酶抑制化合物的椎管狭窄的预防和/或治疗剂。 醛糖还原酶抑制化合物的代表性实例是由式（I）表示的化合物：
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公开(公告)号：US20110015238A1
公开(公告)日：2011-01-20
申请号：US12889731
申请日：2010-09-24
IPC分类号： A61K31/429 , C07D417/12 , A61K31/427 , A61P9/12 , A61K31/5575 , C07C405/00 , C07D515/18
CPC分类号： A61K31/5575 , A61K31/427 , A61K31/429 , A61K31/559 , C07C405/00 , C07D277/56
摘要： It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
摘要翻译： 旨在为马尾组织提供高度安全有效的血液流动促进剂。 在具有低血压降低作用的前列腺素样化合物中，具有促进马尾组织（不包括利马前列素）中的血流的作用的化合物可用作马尾组织的高度安全的血液流动促进剂，因此有效地预防和/ 或治疗由马尾损伤引起的腰痛，下肢疼痛，下肢麻痹，间歇性跛行，膀胱直肠功能衰竭，性腺机能减退等。
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公开(公告)号：US20070167403A1
公开(公告)日：2007-07-19
申请号：US10551755
申请日：2004-04-02
IPC分类号： A61K31/724 , A61K31/557 , A61K31/045
CPC分类号： A61K45/06
摘要： A remedy for spinal canal stenosis which comprises a combination of a compound having EP2 agonism with a compound having EP3 agonism. A drug comprising a combination of a compound having EP2 agonism with a compound having EP3 agonism shows an efficacy in a rat gait disorder model induced by compression of cauda equina. Namely, it is efficacious against spinal canal stenosis to use a combination of a compound having EP2 agonism with a compound having EP3 agonism or a compound having both EP2 agonism and EP3 agonism.
摘要翻译： 包括具有EP2激动作用的化合物与具有EP3激动作用的化合物的组合的椎管狭窄的补救措施。 包含具有EP2激动作用的化合物与具有EP3激动作用的化合物的组合的药物显示在通过马尾巴压迫诱发的大鼠步态障碍模型中的功效。 即，使用具有EP2激动作用的化合物与具有EP3激动作用的化合物或具有EP2激动作用和EP3激动作用的化合物的组合来对椎管狭窄有效。
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公开(公告)号：US08501793B2
公开(公告)日：2013-08-06
申请号：US12889731
申请日：2010-09-24
IPC分类号： A61K31/425 , A61K31/19 , A61K31/557
CPC分类号： A61K31/5575 , A61K31/427 , A61K31/429 , A61K31/559 , C07C405/00 , C07D277/56
摘要： It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
摘要翻译： 旨在为马尾组织提供高度安全有效的血液流动促进剂。 在具有低血压降低作用的前列腺素样化合物中，具有促进马尾组织（不包括利马前列素）中的血流的作用的化合物可用作马尾组织的高度安全的血液流动促进剂，因此有效地预防和/ 或治疗由马尾损伤引起的腰痛，下肢疼痛，下肢麻痹，间歇性跛行，膀胱直肠功能衰竭，性腺机能减退等。
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公开(公告)号：US07833995B2
公开(公告)日：2010-11-16
申请号：US10581619
申请日：2004-12-02
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： A61K31/5575 , A61K31/427 , A61K31/429 , A61K31/559 , C07C405/00 , C07D277/56
摘要： It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
摘要翻译： 旨在为马尾组织提供高度安全有效的血液流动促进剂。 在具有低血压降低作用的前列腺素样化合物中，具有促进马尾组织（不包括利马前列素）中的血流的作用的化合物可用作马尾组织的高度安全的血液流动促进剂，因此有效地预防和/ 或治疗由马尾损伤引起的腰痛，下肢疼痛，下肢麻痹，间歇性跛行，膀胱直肠功能衰竭，性腺机能减退等。
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公开(公告)号：US20070129327A1
公开(公告)日：2007-06-07
申请号：US10581619
申请日：2004-12-02
IPC分类号： A61K31/724 , A61K31/558 , A61K31/557
CPC分类号： A61K31/5575 , A61K31/427 , A61K31/429 , A61K31/559 , C07C405/00 , C07D277/56
摘要： It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect of promoting the blood flow in cauda equina tissues (excluding limaprost) are useful as highly safe blood flow promoters for cauda equina tissues and, therefore, are efficacious in preventing and/or treating lumbar pain, lower limb pain, lower limb palsy, intermittent claudication, vesicorectal failure, hypogonadism, etc. caused by cauda equina injuries.
摘要翻译： 旨在为马尾组织提供高度安全有效的血液流动促进剂。 在具有低血压降低作用的前列腺素样化合物中，具有促进马尾组织（不包括利马前列素）中的血流的作用的化合物可用作马尾组织的高度安全的血液流动促进剂，因此有效地预防和/ 或治疗由马尾损伤引起的腰痛，下肢疼痛，下肢麻痹，间歇性跛行，膀胱直肠功能衰竭，性腺机能减退等。
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