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    Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient
    2.
    发明授权
    Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient 失效
    稠合的哒嗪衍生物化合物和含有这些化合物的药物作为活性成分

    公开(公告)号：US07402580B2

    公开(公告)日：2008-07-22

    申请号：US10505012

    申请日：2003-02-18

    申请人： Takuya Seko ,  Jun Takeuchi ,  Shinya Takahashi ,  Yoshihisa Kamanaka ,  Wataru Kamoshima

    发明人： Takuya Seko ,  Jun Takeuchi ,  Shinya Takahashi ,  Yoshihisa Kamanaka ,  Wataru Kamoshima

    IPC分类号： C07D403/12 ,  C07D405/12 ,  C07D237/32 ,  A61K31/502

    CPC分类号： C07D403/06 ,  C07D237/26 ,  C07D237/32 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

    摘要： Fused pyridazine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof (wherein each symbol has the meaning as defined in the specification.). Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV etc.), sensitizers in treating cancer and immunosuppressants.

    摘要翻译： 由式（I）表示的稠合哒嗪衍生物或其药学上可接受的盐（其中每个符号具有说明书中定义的含义）。 由于抑制聚（ADP-核糖）聚合酶，式（I）表示的化合物可用作各种缺血性疾病（脑，脐带，心脏，消化道，骨骼肌，视网膜等）的预防和/或补救措施， ，炎性疾病（炎性肠病，多发性脑血管病，关节炎等），神经变性疾病（锥体外系疾病，阿尔茨海默病，肌营养不良，腰椎管狭窄等），糖尿病，休克，头部创伤，肾衰竭，痛觉过敏， 此外，这些化合物可用作抗逆转录病毒（HIV等），敏化剂治疗癌症和免疫抑制剂的药剂。

    2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient
    4.
    发明授权
    2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient 失效
    2H-酞嗪-1-酮衍生物和含有其衍生物作为活性成分的药物

    公开(公告)号：US06677333B1

    公开(公告)日：2004-01-13

    申请号：US09889925

    申请日：2001-07-25

    申请人： Takuya Seko ,  Jun Takeuchi ,  Shinya Takahashi ,  Masao Naka

    发明人： Takuya Seko ,  Jun Takeuchi ,  Shinya Takahashi ,  Masao Naka

    IPC分类号： A61K31502

    CPC分类号： C07D401/12 ,  A61K31/502 ,  C07D237/32 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

    摘要： Poly(ADP-ribose)polymerase inhibitors containing as the active ingredient 2H-phthalazin-1-one derivatives represented by general formula (I) (wherein each symbol is as defined in the description) or salts thereof. The compounds of the general formula (I) inhibit poly(ADP-ribose)polymerase and are useful as preventives and/or remedies for various ischemic diseases (brain, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory intestinal diseases, multiple encephalosclerosis, arthritis, etc.), nerve degeneration diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, etc.), diabetes, shock, head trauma, renal insufficiency, hyperalgesia, etc. These compounds are also useful as sensitizers for agents against retroviruses (HIV, etc.) and chemotherapy for cancer.

    摘要翻译： 含有作为活性成分的通式（I）表示的2H-酞嗪-1-酮衍生物的聚（ADP-核糖）聚合酶抑制剂（其中各符号如说明书中所定义）或其盐。 通式（I）的化合物抑制聚（ADP-核糖）聚合酶，并且可用作各种缺血性疾病（脑，心脏，消化道，骨骼肌，视网膜等），炎症性疾病的预防和/或治疗 炎症性肠病，多发性脑病，关节炎等），神经变性疾病（锥体外系疾病，阿尔茨海默病，肌营养不良等），糖尿病，休克，头部创伤，肾功能不全，痛觉过敏等。 用于抗逆转录病毒药物（HIV等）和癌症化学疗法的敏化剂。

    Remedy for chronic disease
    7.
    发明授权
    Remedy for chronic disease 失效
    缓解慢性病的治疗方法

    公开(公告)号：US07300917B2

    公开(公告)日：2007-11-27

    申请号：US10519106

    申请日：2003-05-28

    申请人： Shinji Nakade ,  Hiromu Habashita ,  Takuya Seko

    发明人： Shinji Nakade ,  Hiromu Habashita ,  Takuya Seko

    IPC分类号： A61K38/00 ,  C12P13/06

    CPC分类号： C07D213/40 ,  A61K31/4406 ,  C07C233/51 ,  C07C233/66 ,  C07C233/73 ,  C07C233/83 ,  C07C235/48 ,  C07C235/52 ,  C07D231/12 ,  C07D235/12 ,  C07D261/14

    摘要： A remedy and/or a preventive for a chronic disease which contains an EDG-2 antagonist. Because of binding to a subtype EDG-2 of LPA receptor, an EDG-2 antagonist is useful in treating and/or preventing chronic diseases (for example, diseases caused by the progress of chronic asthma, glomerular nephritis, obesity, arteriosclerosis, rheumatoid and atopic diseases) induced and made chronic by tissue cells whose proliferation is accelerated by LPA mediated by EDG-2.

    摘要翻译： 含有EDG-2拮抗剂的慢性疾病的补救措施和/或预防措施。 由于与EDA-2的LPA受体的结合，EDG-2拮抗剂可用于治疗和/或预防慢性疾病（例如由慢性哮喘，肾小球肾炎，肥胖症，动脉硬化，类风湿病， 特应性疾病）由EDG-2介导的LPA加速的组织细胞诱导和慢性。

    β-alanine derivatives and the use thereof
    8.
    发明授权
    β-alanine derivatives and the use thereof 失效
    β-丙氨酸衍生物及其用途

    公开(公告)号：US07285680B2

    公开(公告)日：2007-10-23

    申请号：US10515653

    申请日：2003-05-28

    申请人： Hiromu Habashita ,  Masahiko Terakado ,  Shinji Nakade ,  Takuya Seko

    发明人： Hiromu Habashita ,  Masahiko Terakado ,  Shinji Nakade ,  Takuya Seko

    IPC分类号： C07C233/83 ,  C07C311/46 ,  C07D209/16 ,  C07D213/40 ,  C07D217/06 ,  C07D307/52

    CPC分类号： C07D213/40 ,  C07C233/83 ,  C07C311/46 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/16 ,  C07D213/38 ,  C07D217/06 ,  C07D307/52 ,  C07D333/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

    摘要： A compound of the general formula (I) (wherein the symbols are as defined in the description), or a prodrug or a salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is useful in the prevention and/or treatment of urinary system disease (symptom with prostatic hypertrophy or neurogenic bladder dysfunction disease, symptom to be caused by spinal cord neoplasm, nucleous hernia, spinal canal stenosis or diabetes, lower urinary tract symptom (for example, occlusion disease of lower urinary tract), inflammatory disease of lower urinary tract, polyuria), carcinoma association disease (solid tumor, solid tumor metastasis, angiofibroma, myeloma, multiple myeloma, Kaposi's sarcoma, leucemia and carcinomatous infiltration transition), proliferative disease (disorder with aberrant angiogenesis, artery obstruction and pulmonary fibrosis), inflammation/immune system disease (psoriasis, nephropathy, hepatitis and pneumonitis symptom), disease by secretion fault (Sjogren syndrome) or brain association disease (brain infarction, cerebral apoplexy and brain or peripheral neuropathy).

    摘要翻译： 通式（I）的化合物（其中符号如说明书中所定义）或其前药或其盐。 该化合物参与LPA受体结合和拮抗作用，因此可用于预防和/或治疗泌尿系统疾病（前列腺肥大或神经源性膀胱功能障碍症状，由脊髓肿瘤引起的症状，核疝，椎管狭窄 或糖尿病，下尿路症状（例如下泌尿道闭塞病），下尿路炎性多发尿，多尿症），癌相关疾病（实体瘤，实体瘤转移，血管纤维瘤，骨髓瘤，多发性骨髓瘤，卡波西肉瘤， 炎症/免疫系统疾病（牛皮癣，肾病，肝炎和肺炎症状），分泌性疾病（干燥综合症）或脑关联疾病 （脑梗死，脑中风和脑或周围神经病变）。

    Prostaglandin derivatives
    9.
    发明授权
    Prostaglandin derivatives 失效
    前列腺素衍生物

    公开(公告)号：US5698590A

    公开(公告)日：1997-12-16

    申请号：US701486

    申请日：1996-08-22

    申请人： Akio Nishiura ,  Takuya Seko ,  Ryoji Matsumoto ,  Shin-ichi Hamano

    发明人： Akio Nishiura ,  Takuya Seko ,  Ryoji Matsumoto ,  Shin-ichi Hamano

    IPC分类号： A61K9/127 ,  A61K31/557 ,  C07C405/00

    CPC分类号： C07C405/00 ,  A61K31/557 ,  A61K9/127

    摘要： Prostaglandin E.sub.1 ester derivatives of the formula (I): ##STR1## wherein the R' groups are the same as each other and are C4-12 alkyl; or cyclodextrin clathrates thereof, liposome formulations containing them, and pharmaceutical compositions containing them, as active ingredient. The compounds of formula (I) have the effect of increasing blood flow and are useful for the prevention and/or treatment of peripheral circulatory disorder, decubitus, or skin ulcers, or for the maintenance of blood flow.

    摘要翻译： 式（I）的前列腺素E1酯衍生物：其中R'基彼此相同并且是C 4-12烷基; 或环糊精包合物，含有它们的脂质体制剂和含有它们的药物组合物作为活性成分。 式（I）化合物具有增加血流量的作用，可用于预防和/或治疗周围循环障碍，褥疮或皮肤溃疡，或用于维持血流。