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公开(公告)号：US09175078B2
公开(公告)日：2015-11-03
申请号：US12863737
申请日：2009-01-23
申请人： Tara Arvedson , Gregory Dyas , James B. Rottman , Barbra Sasu , Xiao-juan Bi , Grace Ki Jeong Lee , Jackie Z. Sheng
发明人： Tara Arvedson , Gregory Dyas , James B. Rottman , Barbra Sasu , Xiao-juan Bi , Grace Ki Jeong Lee , Jackie Z. Sheng
IPC分类号： A61K39/395 , C07K16/28 , G01N33/68 , G01N33/90 , A61K39/00
CPC分类号： C07K16/28 , A61K38/1816 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/70 , C07K2317/76 , G01N33/6872 , G01N33/90 , G01N2800/00
摘要： Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.
摘要翻译： 提供了用于治疗铁体内平衡障碍的组合物。 更具体地，提供抗铁绿蛋白抗体，含有此类抗体的组合物，相应的核酸，载体和宿主细胞，以及制备此类抗体的方法。
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公开(公告)号：US06245332B1
公开(公告)日：2001-06-12
申请号：US09232878
申请日：1999-01-15
IPC分类号： A61K3938
CPC分类号： C07K16/2866 , A61K38/195 , A61K2039/505 , C07K16/24
摘要： Methods are provided to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells, without affecting naive T cells or intestinal memory T cells. It is shown that systemic memory T cells, which are characterized as CD45Ra−, and integrin &agr;4&bgr;7−, express high levels of CCR4. Ligands of CCR4, such as TARC or MDC, act as an adhesion trigger, wherein upon CCR4 binding, these cells undergo integrin-dependent arrest to the appropriate vascular receptor(s). This arrest acts to localize the cells at the target site. The methods of the invention manipulate this triggering, and CCR4 mediated chemotaxis, to affect the localization of T cells in targeted tissues. In one embodiment of the invention, the active agent is a CCR4 agonist, that acts to enhance T cell localization. In an alternative embodiment, the agent is an antagonist that blocks CCR4 biological activity. An advantage of the invention is the selectivity for systemic memory T cells, without affecting native T cells or intestinal memory T cells.
摘要翻译： 提供方法以特异性调节系统记忆T细胞，特别是CD4 + T细胞的运输，而不影响幼稚T细胞或肠内记忆T细胞。 其表现为CD45Rα和整合素α4β7-的全身记忆T细胞表达高水平的CCR4。 CCR4的配体如TARC或MDC作为粘附触发剂，其中在CCR4结合时，这些细胞经受整合素依赖性阻滞至合适的血管受体。 这次逮捕行动使细胞在目标地点本地化。 本发明的方法操纵这种触发和CCR4介导的趋化性，以影响T细胞在靶向组织中的定位。 在本发明的一个实施方案中，活性剂是用于增强T细胞定位的CCR4激动剂。 在替代实施方案中，所述试剂是阻断CCR4生物活性的拮抗剂。 本发明的优点是对全身记忆性T细胞的选择性，而不影响天然T细胞或肠内记忆T细胞。
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公开(公告)号：US06881406B2
公开(公告)日：2005-04-19
申请号：US09837446
申请日：2001-04-17
IPC分类号： A61K45/00 , A61K38/00 , A61K38/19 , A61K39/395 , A61P17/02 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P37/02 , A61P37/08 , C07K16/24 , C07K16/28
CPC分类号： C07K16/2866 , A61K38/195 , A61K2039/505 , C07K16/24
摘要： Methods are provided to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells, without affecting naive T cells or intestinal memory T cells. It is shown that systemic memory T cells, which are characterized as CD45Ra−, and integrin α4β7−, express high levels of CCR4. Ligands of CCR4, such as TARC or MDC, act as an adhesion trigger, wherein upon CCR4 binding, these cells undergo integrin-dependent arrest to the appropriate vascular receptor(s). This arrest acts to localize the cells at the target site. The methods of the invention manipulate this triggering, and CCR4 mediated chemotaxis, to affect the localization of T cells in targeted tissues. In an alternative embodiment, the agent is an antagonist that blocks CCR4 biological activity. An advantage of the invention is the selectivity for systemic memory T cells, without affecting native T cells or intestinal memory T cells.
摘要翻译： 提供方法以特异性调节系统记忆T细胞，特别是CD4 + T细胞的运输，而不影响幼稚T细胞或肠内记忆T细胞。 其表征为CD45Rα和/或整合素α4beta7的系统记忆T细胞表达高水平的CCR4。 CCR4的配体如TARC或MDC作为粘附触发剂，其中在CCR4结合时，这些细胞经受整合素依赖性阻滞至合适的血管受体。 这次逮捕行动使细胞在目标地点本地化。 本发明的方法操纵这种触发和CCR4介导的趋化性，以影响T细胞在靶向组织中的定位。 在替代实施方案中，所述试剂是阻断CCR4生物活性的拮抗剂。 本发明的优点是对全身记忆性T细胞的选择性，而不影响天然T细胞或肠内记忆T细胞。
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