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    Streptavidin having low immunogenicity and use thereof
    9.
    发明授权
    Streptavidin having low immunogenicity and use thereof 有权
    具有低免疫原性的链霉亲和素及其用途

    公开(公告)号：US08546537B2

    公开(公告)日：2013-10-01

    申请号：US13202102

    申请日：2010-02-19

    申请人： Tatsuhiko Kodama ,  Takao Hamakubo ,  Hirofumi Doi ,  Akira Sugiyama ,  Kouhei Tsumoto

    发明人： Tatsuhiko Kodama ,  Takao Hamakubo ,  Hirofumi Doi ,  Akira Sugiyama ,  Kouhei Tsumoto

    IPC分类号： C07K14/00 ,  C07H21/02

    CPC分类号： B82Y5/00 ,  A61K47/6898 ,  C07K14/36 ,  C07K16/14 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92

    摘要： It is an object of the present invention to provide a mutant streptavidin wherein the immunogenicity (antigenicity) in mammals of a streptavidin is reduced. The present invention provides a mutant streptavidin, which comprises an amino acid sequence in which (a) the arginine residue at position 72 is substituted with another amino acid residue, and (b) any one or more of the tyrosine residue at position 10, the tyrosine residue at position 71, the glutamic acid residue at position 89, the arginine residue at position 91, and the glutamic acid residue at position 104 are substituted with other amino acid residues, with respect to the amino acid sequence of a core streptavidin as shown in SEQ ID NO: 2, and which has decreased immunogenicity as compared with that of a wild-type streptavidin.

    摘要翻译： 本发明的目的是提供一种突变型链霉抗生物素蛋白，其中链霉亲和素的哺乳动物中的免疫原性（抗原性）降低。 本发明提供一种突变链霉抗生物素蛋白，其包含其中（a）第72位的精氨酸残基被另一个氨基酸残基取代的氨基酸序列，和（b）第10位的任何一个或多个酪氨酸残基， 相对于核心链霉亲和素的氨基酸序列，如图所示，位置71的酪氨酸残基，89位的谷氨酸残基，91位的精氨酸残基和104位的谷氨酸残基被其它氨基酸残基取代 与野生型链霉抗生物素蛋白相比具有降低的免疫原性。

    STREPTAVIDIN HAVING LOW IMMUNOGENICITY AND USE THEREOF
    10.
    发明申请
    STREPTAVIDIN HAVING LOW IMMUNOGENICITY AND USE THEREOF 有权
    具有低免疫原性的STREPTAVIDIN及其使用

    公开(公告)号：US20120039879A1

    公开(公告)日：2012-02-16

    申请号：US13202102

    申请日：2010-02-19

    申请人： Tatsuhiko Kodama ,  Takao Hamakubo ,  Hirofumi Doi ,  Akira Sugiyama ,  Kouhei Tsumoto

    发明人： Tatsuhiko Kodama ,  Takao Hamakubo ,  Hirofumi Doi ,  Akira Sugiyama ,  Kouhei Tsumoto

    IPC分类号： A61K39/395 ,  G01N33/82 ,  C07K19/00 ,  C07K14/36 ,  C12N15/31

    CPC分类号： B82Y5/00 ,  A61K47/6898 ,  C07K14/36 ,  C07K16/14 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92

    摘要： It is an object of the present invention to provide a mutant streptavidin wherein the immunogenicity (antigenicity) in mammals of a streptavidin is reduced. The present invention provides a mutant streptavidin, which comprises an amino acid sequence in which (a) the arginine residue at position 72 is substituted with another amino acid residue, and (b) any one or more of the tyrosine residue at position 10, the tyrosine residue at position 71, the glutamic acid residue at position 89, the arginine residue at position 91, and the glutamic acid residue at position 104 are substituted with other amino acid residues, with respect to the amino acid sequence of a core streptavidin as shown in SEQ ID NO: 2, and which has decreased immunogenicity as compared with that of a wild-type streptavidin.

    摘要翻译： 本发明的目的是提供一种突变型链霉抗生物素蛋白，其中链霉亲和素的哺乳动物中的免疫原性（抗原性）降低。 本发明提供一种突变链霉抗生物素蛋白，其包含其中（a）第72位的精氨酸残基被另一个氨基酸残基取代的氨基酸序列，和（b）第10位的任何一个或多个酪氨酸残基， 相对于核心链霉亲和素的氨基酸序列，如图所示，位置71的酪氨酸残基，89位的谷氨酸残基，91位的精氨酸残基和104位的谷氨酸残基被其它氨基酸残基取代 与野生型链霉抗生物素蛋白相比具有降低的免疫原性。