利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

35 条记录 (耗时 0.022 秒)

    Antibacterial compounds, and use
    1.
    发明授权
    Antibacterial compounds, and use 失效
    抗菌化合物及用途

    公开(公告)号：US4839351A

    公开(公告)日：1989-06-13

    申请号：US941069

    申请日：1986-12-12

    申请人： Tatsuo Nishimura ,  Yoshinobu Yoshimura ,  Akio Miyake ,  Naoto Hashimoto

    发明人： Tatsuo Nishimura ,  Yoshinobu Yoshimura ,  Akio Miyake ,  Naoto Hashimoto

    IPC分类号： C07D519/06 ,  A61K31/545 ,  A61P31/04 ,  C07D463/00 ,  C07D501/36 ,  C07D505/00 ,  C07D519/00

    CPC分类号： C07D505/00 ,  C07D463/22 ,  Y02P20/55

    摘要： A compound of the general formula: ##STR1## wherein R.sup.0 is hydrogen, a nitrogen-containing heterocyclic group, an acyl group or an amino-protective group; A is S, S.fwdarw.O, O or CH.sub.2 ; R.sup.4 is hydrogen, methoxy group or formamido group; R.sup.13 is hydrogen, methyl, hydroxyl or a halogen; and A is an optionally substituted condensed cyclic group formed by combining an imidazole or pyrazole ring with 5- or 6-membered nitrogen-containing aromatic heterocyclic ring to share a C-N bond with each other,or a salt or ester thereof.and a process for preparing the same and a pharmaceutical composition thereof are disclosed.

    摘要翻译： 通式为：其中R 0为氢，含氮杂环基，酰基或氨基保护基的化合物。 A是S，S-> O，O或CH 2; R4是氢，甲氧基或甲酰氨基; R 13是氢，甲基，羟基或卤素; A是通过将咪唑或吡唑环与5-或6-元含氮芳族杂环相结合而形成的任选取代的稠合环状基团，以共价C-N键或其盐或酯。 并公开了其制备方法及其药物组合物。

    Cephem compounds, their production and use
    2.
    发明授权
    Cephem compounds, their production and use 失效
    头孢烯化合物，其生产和使用

    公开(公告)号：US4921851A

    公开(公告)日：1990-05-01

    申请号：US396758

    申请日：1989-08-22

    申请人： Shoji Kishimoto ,  Kiminori Tomimatsu ,  Akio Miyake ,  Yoshinobu Yoshimura

    发明人： Shoji Kishimoto ,  Kiminori Tomimatsu ,  Akio Miyake ,  Yoshinobu Yoshimura

    IPC分类号： C07D501/00 ,  C07D501/46 ,  C07D519/00

    CPC分类号： C07D501/46 ,  C07D501/00 ,  C07D519/00

    摘要： This invention relates to a compound of the formula: ##STR1## wherein Q is nitrogen or CH; R.sup.1 is hydrogen or a lower alkyl group which may be substituted; and ring A is a pyridine or pyridazine ring which is substituted at the ring-constituting carbon atom by a group of the formula:--E--(CH.sub.2).sub.n --R.sup.2in which E is sulfur or NH; R.sup.2 is an amino, carbamoylamino, formylamino, acetylamino, N-formimidoylamino, N-acetimidoylamino, lower alkylamino, hydroxyl or carbamoyloxy group; and n is an integer of 2 to 4, or a pharmaceutically acceptable salt thereof. The compound (I) or a pharmaceutically acceptable sale thereof has excellent antibacterial activity and is used as antibiotics.

    摘要翻译： 本发明涉及下式的化合物：其中Q是氮或CH; R1是氢或可被取代的低级烷基; 环A为吡啶或哒嗪环，其在环的构成碳原子上被下列基团取代：其中E为硫或NH的-E-（CH2）n-R2; R2是氨基，氨基甲酰基氨基，甲酰氨基，乙酰氨基，N-甲脒基氨基，N-亚氨代乙酰氨基，低级烷基氨基，羟基或氨基甲酰氧基; n为2〜4的整数，或其药学上可接受的盐。 化合物（I）或其药学上可接受的销售具有优异的抗菌活性并用作抗生素。

    1-Acyloxyalkyl esters of cephalosporin
    3.
    发明授权
    1-Acyloxyalkyl esters of cephalosporin 失效
    头孢菌素的1-芳氧基烷基酯

    公开(公告)号：US4797395A

    公开(公告)日：1989-01-10

    申请号：US886814

    申请日：1986-07-18

    申请人： Akio Miyake ,  Yoshinobu Yoshimura ,  Mitsuo Numata

    发明人： Akio Miyake ,  Yoshinobu Yoshimura ,  Mitsuo Numata

    IPC分类号： A61K31/545 ,  C07D501/36 ,  C07D501/56

    CPC分类号： C07D501/36

    摘要： A compound of the formula ##STR1## wherein (1) R.sub.1 is a lower alkyl group of 2 to 6 carbon atoms or a cycloalkyl group of 5 to 7 carbon atoms and R.sub.2 is a cycloalkyl group of 5 to 7 carbon atoms or a lower alkyl group of 1 to 3 carbon atoms which is substituted by a cycloalkyl group of 5 to 7 carbon atoms or by a phenyl group, or (2) R.sub.1 is a cycloalkyl group of 5 to 7 carbon atoms and R.sub.2 is a lower alkyl group of 1 to 5 carbon atoms, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a pharmaceutical composition thereof are provided. The compound can orally be applied as antibiotics having improved bioavailability.

    摘要翻译： 式（Ⅰ）化合物其中（1）R 1为2〜6个碳原子的低级烷基或5〜7个碳原子的环烷基，R 2为5〜7个碳原子的环烷基 原子或碳原子数为5〜7的环烷基取代的1〜3个碳原子的低级烷基或苯基，或（2）R 1为5〜7个碳原子的环烷基，R 2为 提供1〜5个碳原子的低级烷基或其药学上可接受的盐，其制备方法及其药物组合物。 该化合物可口服施用，具有改善生物利用度的抗生素。

    Imidazopyridazines, their production and use
    5.
    发明授权
    Imidazopyridazines, their production and use 失效
    咪达唑德他们的生产和使用

    公开(公告)号：US5145850A

    公开(公告)日：1992-09-08

    申请号：US659704

    申请日：1991-02-25

    申请人： Akio Miyake ,  Yasuko Ashida

    发明人： Akio Miyake ,  Yasuko Ashida

    IPC分类号： A61K31/50 ,  A61K31/5025 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P29/00 ,  A61P37/08 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： An imidazo [1,2-b]pyridazine compound of the formula (I): ##STR1## wherein R.sub.1 is a halogen atom or a lower alkyl group optionally having substituent(s), R.sub.2 and R.sub.3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R.sub.2 and R.sub.3 together with the adjacent nitrogen atom to which they bond may form a heterolcyclic ring optionally having substituent(s), X is an oxygen atom or S(O).sub.k (k is zero to two), a group --.circle.A-- is a bivalent three to seven membered homocyclic or heterocyclic group optionally having substituent(s), m.sup.1 and m.sup.2 each is an integer of 0 to 4 and n is an integer of 0 or 1; or its salt, which is useful as antiasthmatics.

    Cephem compounds, their production and use
    7.
    发明授权
    Cephem compounds, their production and use 失效
    头孢烯化合物，其生产和使用

    公开(公告)号：US5948774A

    公开(公告)日：1999-09-07

    申请号：US836424

    申请日：1997-07-29

    申请人： Keiji Kamiyama ,  Kenji Okonogi ,  Akio Miyake

    发明人： Keiji Kamiyama ,  Kenji Okonogi ,  Akio Miyake

    IPC分类号： C07D501/00 ,  C07D501/24 ,  A61K31/545

    CPC分类号： C07D501/00

    摘要： Cephem compounds of the formula: ##STR1## wherein R.sup.1 is an optionally protected amino group; R.sup.2 is a fluoro-lower alkyl group; and the ring A may have further substituent(s), or their esters or salts, show broad and excellent antibacterial activities and are useful as antibacterial agents.

    摘要翻译： PCT No.PCT / JP96 / 01436 Sec。 371日期1997年7月29日第 102（e）日期1997年7月29日PCT提交1996年5月28日PCT公布。 WO96 / 34851 PCT出版物 日期：1996年12月5日化学式：其中R1为任选保护的氨基; R2是氟代低级烷基; 并且环A可以具有其它取代基或其酯或盐，显示出广泛和优异的抗菌活性并且可用作抗菌剂。

    Triazolopyridazine derivatives, their production and use
    8.
    发明授权
    Triazolopyridazine derivatives, their production and use 失效
    三唑并哒嗪衍生物，其生产和使用

    公开(公告)号：US5492909A

    公开(公告)日：1996-02-20

    申请号：US225981

    申请日：1994-04-12

    申请人： Akio Miyake ,  Masahiro Kajino ,  Yasuko Ashida

    发明人： Akio Miyake ,  Masahiro Kajino ,  Yasuko Ashida

    IPC分类号： C07D487/04 ,  A61K31/50 ,  A61K31/535 ,  C07D487/14

    CPC分类号： C07D487/04

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group or a halogen atom; R.sup.2 and R.sup.3 are a hydrogen atom, a lower alkyl group or a 5- to 7-membered cyclic group formed together with the adjacent --C.dbd.C--; X is an oxygen atom, a sulfur atom or a methylene group; Y is an optionally substituted methylene group, a divalent 3- to 7-membered homo- or heterocyclic group; R.sup.6 and R.sup.7 are a hydrogen atom, a lower alkyl group, a cycloalkyl group, an aryl group, or a nitrogen-containing heterocyclic group formed together With the adjacent nitrogen atom; m is an integer of 0 to 4; and n is an integer of 0 to 4, or a salt thereof. Said compound has an excellent anti-PAF activity, antiallergic action, etc., thus is useful as an antiasthmatic agent.

    摘要翻译： 下式的化合物：其中R 1是氢原子，低级烷基或卤素原子; R2和R3是与相邻的-C = C-一起形成的氢原子，低级烷基或5-至7-元环基; X是氧原子，硫原子或亚甲基; Y是任选取代的亚甲基，二价3-至7-元同 - 或杂环基; R6和R7是与相邻的氮原子一起形成的氢原子，低级烷基，环烷基，芳基或含氮杂环基; m为0〜4的整数。 n为0〜4的整数，或其盐。 所述化合物具有优异的抗PAF活性，抗过敏作用等，因此可用作抗哮喘药。

    1-Acyloxyalkyl esters of cephalosporin
    10.
    发明授权
    1-Acyloxyalkyl esters of cephalosporin 失效
    头孢菌素的1-芳氧基烷基酯

    公开(公告)号：US4725592A

    公开(公告)日：1988-02-16

    申请号：US637138

    申请日：1984-08-03

    申请人： Akio Miyake ,  Masayoshi Yamaoka ,  Mitsuo Numata

    发明人： Akio Miyake ,  Masayoshi Yamaoka ,  Mitsuo Numata

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/36 ,  C07D501/56

    CPC分类号： C07D501/36

    摘要： A compound of the formula: ##STR1## wherein R.sub.1 stands for n-propyl or isopropyl; and R.sub.2 stands for n-butyl, isobutyl, n-pentyl, n-hexyl or 2-ethylbutyl, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a pharmaceutical composition thereof are provided. The compound can orally be applied as antibiotics having improved bioavailability.

    摘要翻译： 下式的化合物：其中R 1代表正丙基或异丙​​基; R2代表正丁基，异丁基，正戊基，正己基或2-乙基丁基，或其药学上可接受的盐，其制备方法及其药物组合物。 该化合物可口服施用，具有改善生物利用度的抗生素。