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12 条记录 (耗时 0.023 秒)

    Long-lasting multi-layered film preparation
    1.
    发明授权
    Long-lasting multi-layered film preparation 失效
    持久的多层膜制备

    公开(公告)号：US4552751A

    公开(公告)日：1985-11-12

    申请号：US312458

    申请日：1981-10-19

    申请人： Kohji Inaba ,  Seiei Sasatani ,  Tatsushi Koide ,  Tamio Nanya

    发明人： Kohji Inaba ,  Seiei Sasatani ,  Tatsushi Koide ,  Tamio Nanya

    IPC分类号： A61K9/02 ,  A61K9/70 ,  A61K31/557 ,  A01N25/26 ,  A01N25/34

    CPC分类号： A61K9/7092 ,  A61K31/557

    摘要： The present invention provides multi-layered film preparations which comprise one or more water soluble polymer bases, one or more water insoluble polymer bases, one or more plasticizers and one or more prostaglandins, and optionally contain one or more organic acids, and they are composed of at least two drug release controlling layers and one or more drug storing layers. The multi-layered film preparations of the present invention are characterized by that the prostaglandin(s) containing therein exhibit the desired long-lasting release patterns at the concentration required for therapeutic purpose.

    摘要翻译： 本发明提供了多层膜制剂，其包含一种或多种水溶性聚合物基质，一种或多种水不溶性聚合物基质，一种或多种增塑剂和一种或多种前列腺素，并且任选地含有一种或多种有机酸，并且它们组成 的至少两个药物释放控制层和一个或多个药物储存层。 本发明的多层膜制剂的特征在于，其中含有的前列腺素以治疗目的所需的浓度显示出期望的持久释放模式。

    Long-lasting three-layered pharmaceutical film preparations
    2.
    发明授权
    Long-lasting three-layered pharmaceutical film preparations 失效
    持久的三层药膜制剂

    公开(公告)号：US4483846A

    公开(公告)日：1984-11-20

    申请号：US464174

    申请日：1983-02-07

    申请人： Tatsushi Koide ,  Seiei Sasatani ,  Kohji Inaba

    发明人： Tatsushi Koide ,  Seiei Sasatani ,  Kohji Inaba

    IPC分类号： A61K31/557 ,  A61K9/70 ,  A61K45/08 ,  A01N25/26 ,  A01N25/34

    CPC分类号： A61K9/7053 ,  A61K9/7092

    摘要： The present invention provides new three-layered pharmaceutical film preparations which comprise one drug-storing middle layer composed of one or more (a) polyvinylpyrrolidone, (b) hydroxypropyl cellulose, (c) plasticizers and (d) organic acids, containing prostaglandin analogues, and two release-controlling layers on both sides of the said middle layer, composed of one or more (a) hydroxypropyl cellulose and (b) plasticizers, containing or not containing prostaglandin analogues, and which may release the drug at the desired concentration lastingly for an extended period of time, with great high biological availability, and can make this release "zero-order release", and further have improved the stability of the drug contained therein, and in which the form of the preparation is not retained at the administered site after administration.

    摘要翻译： 本发明提供新的三层药物膜制剂，其包含一种药物储存中间层，其由一种或多种（a）聚乙烯吡咯烷酮，（b）羟丙基纤维素，（c）增塑剂和（d）含有前列腺素类似物的有机酸组成， 以及由所述中间层两侧的两个释放控制层，由一种或多种（a）羟丙基纤维素和（b）增塑剂组成，所述增塑剂含有或不含有前列腺素类似物，并且可以持续释放所需浓度的药物以用于 延长的时间，具有很高的生物利用度，并且可以使这种释放“零次释放”，并且进一步改善了其中所含药物的稳定性，并且其中制剂形式不保留在给药 管理后的网站。

    Toner image transfer method
    4.
    发明授权
    Toner image transfer method 失效
    墨粉图像传输方式

    公开(公告)号：US5480759A

    公开(公告)日：1996-01-02

    申请号：US425355

    申请日：1995-04-19

    申请人： Takashige Kasuya ,  Noboru Kashimura ,  Tatsuya Nakamura ,  Tatsuhiko Chiba ,  Kohji Inaba

    发明人： Takashige Kasuya ,  Noboru Kashimura ,  Tatsuya Nakamura ,  Tatsuhiko Chiba ,  Kohji Inaba

    IPC分类号： G03G5/05 ,  G03G5/087 ,  G03G5/14 ,  G03G5/147 ,  G03G13/08 ,  G03G15/00 ,  G03G13/22 ,  G03G13/16

    CPC分类号： G03G15/75 ,  G03G13/08 ,  G03G5/0514 ,  G03G5/0517 ,  G03G5/0539 ,  G03G5/0578 ,  G03G5/087 ,  G03G5/14704 ,  G03G5/14726 ,  G03G5/14773 ,  G03G5/0546 ,  G03G5/0564 ,  G03G5/142 ,  G03G5/14756

    摘要： An electrophotographic toner showing a good fixability onto recording paper is constituted by at least a binder resin and a colorant, the binder resin comprising a resin component having a polar group, the binder resin having a molecular weight distribution according to gel permeation chromatography including a peak in a molecular weight region of 5.times.10.sup.3 -5.times.10.sup.4. The toner is used to develop an electrostatic image formed on a electrophotographic photosensitive member including at least an electroconductive support, a charge generation layer and a charge transport layer, and the resultant toner image is transferred onto a recording medium without difficulties such as occurrence of cracks on the photosensitive member or inferior transferability by using a photosensitive member having a surface layer containing a transition metal atom at 0.1-10 ppm. The surface of the photosensitive member may preferably show a fluorine atom/carbon atom (F/C) ratio or/and a silicon atom/carbon atom (Si/C) ratio, respectively, of 0.03-1.0 as measured by X-ray photoelectron spectroscopy.

    摘要翻译： 显示在记录纸上的良好定影性的电子照相调色剂由至少粘合剂树脂和着色剂构成，粘合剂树脂包含具有极性基团的树脂组分，粘合剂树脂具有根据凝胶渗透色谱法的分子量分布，包括峰 在5×10 3〜5×10 4的分子量范围内。 调色剂用于显影形成在电子照相感光构件上的静电图像，其至少包括导电性支持体，电荷产生层和电荷输送层，并且将所得到的调色剂图像转印到记录介质上，没有发生裂纹的困难 通过使用具有含有0.1-10ppm的过渡金属原子的表面层的感光构件，在感光构件上具有较差的转印性。 感光构件的表面可以优选地表现出通过X射线光电子测量的0.03-1.0的氟原子/碳原子（F / C）比或/和硅原子/碳原子（Si / C）比 光谱学。

    Toner for developing electrostatic image
    6.
    发明授权
    Toner for developing electrostatic image 失效
    用于显影静电图像的调色剂

    公开(公告)号：US5750303A

    公开(公告)日：1998-05-12

    申请号：US841337

    申请日：1997-04-30

    申请人： Kohji Inaba ,  Kazunori Kato ,  Kengo Hayase

    发明人： Kohji Inaba ,  Kazunori Kato ,  Kengo Hayase

    IPC分类号： G03G9/087 ,  G03G9/093 ,  G03G9/097

    CPC分类号： G03G9/08755 ,  G03G9/08782 ,  G03G9/08791 ,  G03G9/08793 ,  G03G9/08795 ,  G03G9/08797 ,  G03G9/09328

    摘要： A toner for developing an electrostatic image includes toner particles constituted by at least a binder resin, a colorant, a polar resin and a release agent. The polar resin has at least one terminal group which has been modified by a polycarbonate acid having at least three carboxyl groups. The polar resin has an acid value of 3-35 mgKOH/g. The polar resin may preferably be a polyester resin having an acid value of 4-35 mgKOH/g and having a number-average molecular weight (Mn) of 3,000-15,000, a weight-average molecular weight (Mw) of 6,000-50,000, and an Mw/Mn of 1.2-3.0 based on GPC. The polar resin (preferably polyester resin) having modified by a polycarboxylic acid having at least three carboxylic groups to provide a specific acid value is effective in improving resultant toner performances, such as low-temperature fixability, anti-offset characteristic at high temperatures, triboelectric chargeability, and flowability.

    摘要翻译： 用于显影静电图像的调色剂包括由至少粘合剂树脂，着色剂，极性树脂和脱模剂构成的调色剂颗粒。 极性树脂具有至少一个末端基团，其被具有至少三个羧基的聚碳酸酯改性。 极性树脂的酸值为3-35mgKOH / g。 极性树脂可以优选为酸值为4-35mgKOH / g，数均分子量（Mn）为3,000-15,000，重均分子量（Mw）为6,000-50,000的聚酯树脂， 和基于GPC的Mw / Mn为1.2-3.0。 通过具有至少三个羧基的多元羧酸改性以提供特定酸值的极性树脂（优选聚酯树脂）在改善所得调色剂性能方面是有效的，例如低温定影性，高温下的抗偏移特性，摩擦电 充电性和流动性。

    Toner for developing electrostatic images and image forming method
    8.
    发明授权
    Toner for developing electrostatic images and image forming method 失效
    用于显影静电图像和成像方法的调色剂

    公开(公告)号：US5635325A

    公开(公告)日：1997-06-03

    申请号：US452344

    申请日：1995-05-26

    申请人： Kohji Inaba ,  Tatsuya Nakamura ,  Tatsuhiko Chiba ,  Takao Ishiyama ,  Kengo Hayase

    发明人： Kohji Inaba ,  Tatsuya Nakamura ,  Tatsuhiko Chiba ,  Takao Ishiyama ,  Kengo Hayase

    IPC分类号： G03G9/087 ,  G03G9/097 ,  G03G13/16

    CPC分类号： G03G9/08782 ,  G03G9/09733

    摘要： A toner for developing electrostatic images includes: at least a binder resin, a colorant and an ester wax. The ester wax is contained in 3-40 wt. parts per 100 wt. parts of the binder resin. The ester wax includes ester compounds represented by a formula ofR.sub.1 --COO--R.sub.2,wherein R.sub.1 an R.sub.2 independently denote a hydrocarbon group of 15-45 carbon atoms. The ester wax contains 50-95 wt. % thereof of ester compounds having an identical number of total carbon atoms. The toner is especially characterized by low-temperature fixability, wide non-offset temperature range, good color mixing characteristic and transparency.

    摘要翻译： 用于显影静电图像的调色剂包括：至少粘合剂树脂，着色剂和酯蜡。 酯蜡包含在3-40wt。 每100重量份 部分粘合剂树脂。 酯蜡包括由式R 1 -COO-R 2表示的酯化合物，其中R 1，R 2独立地表示15-45个碳原子的烃基。 酯蜡含有50-95wt。 ％的具有相同数目的总碳原子的酯化合物。 该调色剂的特征在于低温定影性，非偏移温度范围宽，色彩混合特性和透明度。

    Toner and image forming method
    10.
    发明授权
    Toner and image forming method 有权
    调色剂和成像方法

    公开(公告)号：US06183927B2

    公开(公告)日：2001-02-06

    申请号：US09338422

    申请日：1999-06-23

    申请人： Michihisa Magome ,  Hiroaki Kawakami ,  Tatsuya Nakamura ,  Tatsuhiko Chiba ,  Kohji Inaba ,  Yuji Moriki ,  Shinya Yachi

    发明人： Michihisa Magome ,  Hiroaki Kawakami ,  Tatsuya Nakamura ,  Tatsuhiko Chiba ,  Kohji Inaba ,  Yuji Moriki ,  Shinya Yachi

    IPC分类号： G03G9097

    CPC分类号： G03G9/0821 ,  G03G9/0819 ,  G03G9/0975 ,  G03G9/09783 ,  G03G9/09791

    摘要： An electrophotographic toner is formed of toner particles each comprising at least a binder resin, a colorant and a release agent, and a low-crystalline aromatic metal compound present at surfaces of the toner particles. The toner has an average circularity of at least 0.955, and the low-crystalline aromatic metal compound has an X-ray diffraction characteristic free from peaks exhibiting a measurement intensity of at least 10000 cps and a half-value half-width of at most 0.3 deg. in a range of measurement angles 2&thgr; of 6 to 40 deg. Because of the low crystallinity, the aromatic metal compound is uniformly applied onto the toner particle surfaces to stabilize the chargeability and transferability of the toner.

    摘要翻译： 电子照相调色剂由调色剂颗粒形成，每个调色剂颗粒至少包含粘合剂树脂，着色剂和脱模剂，以及存在于调色剂颗粒表面的低结晶芳族金属化合物。 调色剂的平均圆形度至少为0.955，低结晶性芳香族金属化合物的X射线衍射特性，不存在显示出至少10000cps的测定强度和0.5以下的半值半值的峰值 度 在测量角度2θ为6至40度的范围内。 由于低结晶度，将芳族金属化合物均匀地施加到调色剂颗粒表面上，以稳定调色剂的带电性和转印性。