公开(公告)号：US20070286801A1

公开(公告)日：2007-12-13

申请号：US10341316

申请日：2003-01-10

申请人： Tatsushi Toyokuni ,  Nagichettiar Satyamurthy ,  Harvey Herschman ,  Michael Phelps ,  Jorge Barrio

发明人： Tatsushi Toyokuni ,  Nagichettiar Satyamurthy ,  Harvey Herschman ,  Michael Phelps ,  Jorge Barrio

IPC分类号： A61K51/00 ,  A61K31/42 ,  C07D261/06

CPC分类号： A61K49/10 ,  A61K51/0453

摘要： This invention provides novel cyclooxygenase-2 selective agents that are particularly useful as imaging probes in non-invasive imaging techniques, such as PET and SPECT. Preferred cyclooxygenase-2 selective agents inhibit cyclooxygenase-2 activity with greater potency and specificity than conventional cyclooxygenase-2 inhibitors. Other aspects of the invention include pharmaceutical compositions including the cyclooxygenase-2 selective agents as well as methods for detecting and/or inhibiting cyclooxygenase-2. These methods are particularly useful for diagnosing and treating disorders, such as inflammation, which is characterized by elevated cyclooxygenase-2 levels.

摘要翻译： 本发明提供了新的环加氧酶-2选择剂，其特别可用作非侵入性成像技术如PET和SPECT中的成像探针。 优选的环氧合酶-2选择剂以比常规环加氧酶-2抑制剂更强的效力和特异性抑制环氧合酶-2活性。 本发明的其它方面包括包含环氧合酶-2选择剂的药物组合物以及用于检测和/或抑制环氧合酶-2的方法。 这些方法对于诊断和治疗诸如炎症的疾病特别有用，其特征在于环氧合酶-2水平升高。

公开(公告)号：US20070097858A1

公开(公告)日：2007-05-03

申请号：US11263772

申请日：2005-11-01

申请人： Gregg Lesartre ,  Michael Phelps

发明人： Gregg Lesartre ,  Michael Phelps

IPC分类号： H04J3/14 ,  H04J1/16

CPC分类号： H04L1/22 ,  G06F11/2007 ,  G06F13/4022 ,  H04L1/188 ,  H04L1/189 ,  H04L49/1515 ,  H04L49/552

摘要： A method for employing an interconnection fabric of a computer system including a first endnode and a second endnode is provided. A first transaction is transferred from the first endnode toward the second endnode over a primary path of the fabric. The first transaction is retransferred from the first endnode toward the second endnode over an alternate path of the fabric after a period of time after transferring the first transaction. An acknowledgement of the first transaction being received by the second endnode over the primary path is transferred to the first endnode after retransferring the first transaction. A second transaction from the first endnode toward the second endnode is transferred solely over the primary path after the acknowledgement is received by the first endnode.

摘要翻译： 提供了一种采用包括第一端节点和第二端节点的计算机系统的互连结构的方法。 第一个事务从第一个endnode转移到第二个endnode，超过了Fabric的主要路径。 在传送第一个事务之后的一段时间之后，第一个事务在第一个结尾节点上重新传输到第二个结束节点的另一个路由。 在重新传送第一个事务之后，由第二终端在主路径上接收的第一个事务的确认被传送到第一个结束节点。 在第一个端节点接收到确认之后，从第一个端节点到第二个节点的第二个事务仅在主路径上传输。

公开(公告)号：US20070097953A1

公开(公告)日：2007-05-03

申请号：US11266549

申请日：2005-11-03

申请人： Gregg Lesartre ,  Michael Phelps

发明人： Gregg Lesartre ,  Michael Phelps

IPC分类号： H04L12/28

CPC分类号： G06F13/4022

摘要： A method for controlling data transfers through a computer system is provided. First information is transferred to a first node of the computer system regarding availability of a first data storage area within a second node of the computer system for data to be transferred through the second node. Also transferred to the first node is second information regarding availability of a second data storage area within the second node for data to be consumed within the second node. The first information and the second information are then processed to determine if data within the first node destined for the second node is to be transferred to the second node.

摘要翻译： 提供了一种通过计算机系统控制数据传输的方法。 第一信息被传送到计算机系统的第一节点，关于计算机系统的第二节点内的第一数据存储区域的可用性，以便通过第二节点传送数据。 还传送到第一节点的第二信息是关于第二节点内的第二数据存储区域的可用性的第二信息，用于在第二节点内消耗的数据。 然后处理第一信息和第二信息以确定目的地为第二节点的第一节点内的数据是否被传送到第二节点。