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公开(公告)号:US20080040865A1
公开(公告)日:2008-02-21
申请号:US10579490
申请日:2004-11-08
申请人: Ted Deisenroth , Kamalesh Pai Fondekar , Peter Rohringer , Fabienne Cuesta , Ramachandra V. Joshi , Smita G. Kavishwar , Uma Shadakshari
发明人: Ted Deisenroth , Kamalesh Pai Fondekar , Peter Rohringer , Fabienne Cuesta , Ramachandra V. Joshi , Smita G. Kavishwar , Uma Shadakshari
摘要: A whitening pigment comprising the reaction product of (a) a melamine-formaldehyde and/or a melamine-urea poly-condensation product and (b) a water-soluble fluorescent whitening agent of the formula (1), wherein each of the two R1 groups, independent of the other, represents a C1-C6alkyl or C1-C4alkyl-O—C1-C4alkyl residue, which is substituted by one or two —CONH2, —CONHC1-C4alkyl, —COOH, —SO2NH2, —SO2NHC1-C4alkyl or —NH2 groups, each of the two R2 groups, independent of the other, represents hydrogen, C1-C4alkyl, C2-C4hydroxyalkyl or C1-C4alkoxyC1-C4alkyl, or R1 and R2 together with the nitrogen atom complete a piperazine ring, each of the two X1 groups, independently, represent —OH, —OC1-C4alkyl, —Oaryl or the group —NR3R4, wherein R3 and R4 each, independently, represent hydrogen, C1-C4alkyl, C2-C4hydroxyalky, C1-C4alkoxyC1-C4alkyl, a phenyl, phenyl mono- or disulphonic acid residue or, R3 and R4, together with the nitrogen atom to which they are attached, complete a morpholino, piperidino or pyrrolidino ring or, alternatively, X1 represents an amino acid residue from which a hydrogen atom has been abstracted from the amino group and M is hydrogen, an alkaline or alkaline earth metal ion, ammonium, mono- di-, tri- or tetra-substituted C1-C4alkylammonium or C2-C4hydroxyalkylammonium or mixtures thereof, a process for preparation of the pigments and the use thereof for the fluorescent whitening of paper.
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公开(公告)号:US08106189B2
公开(公告)日:2012-01-31
申请号:US12193857
申请日:2008-08-19
IPC分类号: C07D487/12 , C07D491/00
CPC分类号: C07D487/04 , C07D495/14
摘要: An improved process for preparation of triazol-benzodiazepine derivatives, such as alprazolam, triazolam, brotizolam and etizolam, is presented. The process comprises a cyclization reaction of compound Formula B in toluene with catalytic amount of p-toluene sulphonic acid to obtain the triazol-benzodiazepine derivative of Formula C: wherein R is, and X is hydrogen or halogen.
摘要翻译: 提出了一种用于制备三唑 - 苯并二氮杂衍生物的改进方法,例如阿普唑仑,三唑仑,brotizolam和etizolam。 该方法包括化合物B在甲苯中与催化量的对甲苯磺酸的环化反应,得到式C的三唑 - 苯并二氮杂衍生物:其中R是,X是氢或卤素。
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公开(公告)号:US20090093629A1
公开(公告)日:2009-04-09
申请号:US12193857
申请日:2008-08-19
IPC分类号: C07D495/14 , C07D487/04
CPC分类号: C07D487/04 , C07D495/14
摘要: An improved process for preparation of triazol-benzodiazepine derivatives, such as alprazolam, triazolam, brotizolam and etizolam, is presented. The process comprises a cyclization reaction of compound Formula B in toluene with catalytic amount of p-toluene sulphonic acid to obtain the triazol-benzodiazepine derivative of Formula C: wherein R is, and X is hydrogen or halogen.
摘要翻译: 提出了一种用于制备三唑 - 苯并二氮杂衍生物的改进方法,例如阿普唑仑,三唑仑,brotizolam和etizolam。 该方法包括化合物B在甲苯中与催化量的对甲苯磺酸的环化反应,得到式C的三唑 - 苯并二氮杂衍生物:其中R是,X是氢或卤素。
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