公开(公告)号：US11820833B2

公开(公告)日：2023-11-21

申请号：US16306920

申请日：2017-06-02

Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Nicola Maggio ,  Joab Chapman ,  Efrat Shavit Stein

IPC: C07K5/103 ,  C07K5/113 ,  C07K7/06 ,  C07K14/745 ,  C12N9/64 ,  C12N9/74 ,  A61K38/00 ,  A61P37/06 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07K5/1008 ,  A61P25/00 ,  A61P29/00 ,  A61P37/06 ,  C07K5/1021 ,  C07K7/06 ,  C07K14/745 ,  C12N9/644 ,  C12N9/6429 ,  C12N9/6432 ,  C12N9/6437 ,  C12N9/6464 ,  A61K38/00

Abstract: An isolated peptide of up to 6 amino acids comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR is disclosed. Also disclosed is an isolated peptide comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR, wherein the peptide comprises a modification in at least one amino acid. Also disclosed is a molecule comprising an amino acid sequence which inhibits binding of an endothelial cell protein C receptor (EPCR) ligand to the EPCR attached to a heterologous moiety. Pharmaceutical compositions and methods of treatment are also disclosed.