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公开(公告)号:US20220392640A1
公开(公告)日:2022-12-08
申请号:US17771401
申请日:2020-10-22
申请人: Tempus Labs, Inc.
发明人: Ameen Salahudeen , Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要: Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号:US10975445B2
公开(公告)日:2021-04-13
申请号:US16789363
申请日:2020-02-12
申请人: Tempus Labs, Inc.
发明人: Aarti Venkat , Jerod Parsons , Joshua S K Bell , Catherine Igartua , Yilin Zhang , Ameen Salahudeen , Verónica Sánchez Freire , Robert Tell
摘要: Methods, systems, and software are provided for determining a homologous recombination pathway status of a cancer in a test subject, e.g., to improve cancer treatment predictions and outcomes. In some embodiments, classifiers using one or more of (i) a heterozygosity status for DNA damage repair genes in a cancerous tissue, (ii) a measure of the loss of heterozygosity across the genome of the cancerous tissue, (iii) a measure of variant alleles detected in a second plurality of DNA damage repair genes in the genome of the cancerous tissue, (iv) a measure of variant alleles detected in the second plurality of DNA damage repair genes in the genome of a non-cancerous tissue, and (v) tumor sample purity are provided.
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公开(公告)号:US11415571B2
公开(公告)日:2022-08-16
申请号:US17114386
申请日:2020-12-07
申请人: Tempus Labs, Inc.
发明人: Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要: Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号:US20210246511A1
公开(公告)日:2021-08-12
申请号:US17150615
申请日:2021-01-15
申请人: Tempus Labs, Inc.
发明人: Aarti Venkat , Jerod Parsons , Joshua SK Bell , Catherine Igartua , Yilin Zhang , Ameen Salahudeen , Verónica Sánchez Freire , Robert Tell
摘要: Methods, systems, and software are provided for determining a homologous recombination pathway status of a cancer in a test subject, e.g., to improve cancer treatment predictions and outcomes. In some embodiments, classifiers using one or more of (i) a heterozygosity status for DNA damage repair genes in a cancerous tissue, (ii) a measure of the loss of heterozygosity across the genome of the cancerous tissue, (iii) a measure of variant alleles detected in a second plurality of DNA damage repair genes in the genome of the cancerous tissue, (iv) a measure of variant alleles detected in the second plurality of DNA damage repair genes in the genome of a non-cancerous tissue, and (v) tumor sample purity are provided.
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公开(公告)号:US20220341914A1
公开(公告)日:2022-10-27
申请号:US17857901
申请日:2022-07-05
申请人: Tempus Labs, Inc.
发明人: Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要: Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号:US20210172931A1
公开(公告)日:2021-06-10
申请号:US17114386
申请日:2020-12-07
申请人: Tempus Labs, Inc.
发明人: Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要: Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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