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公开(公告)号：US11415571B2
公开(公告)日：2022-08-16
申请号：US17114386
申请日：2020-12-07
申请人： Tempus Labs, Inc.
发明人： Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号：US20220341914A1
公开(公告)日：2022-10-27
申请号：US17857901
申请日：2022-07-05
申请人： Tempus Labs, Inc.
发明人： Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号：US20210172931A1
公开(公告)日：2021-06-10
申请号：US17114386
申请日：2020-12-07
申请人： Tempus Labs, Inc.
发明人： Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号：US20230036156A1
公开(公告)日：2023-02-02
申请号：US17816395
申请日：2022-07-29
申请人： TEMPUS LABS, INC.
发明人： Chi-Sing Ho , Madhavi Kannan , Sonal Khare , Brian Larsen , Brandon Mapes , Ameen Salahudeen , Jagadish Venkataraman
IPC分类号： G01N33/50 , G06T7/00 , G06T3/00 , G06V20/69 , G06T7/11 , G06V10/774 , G16H15/00 , G16H30/40 , G01N21/64
摘要： A method for characterizing cancer organoid response to an immune cell based therapy, includes providing a panel of different combinations of cancer organoid cells and immune cells to culturing wells and culturing the different combination under conditions that support organoid growth. Brightfield and corresponding fluorescence images of the culturing wells are captured and provided to one or more trained machine learning algorithms that identify and distinguish cancer organoid cells from immune cells and characterize cancer organoid morphology changes caused by an immune cell based therapies, from which an analytical report including a characterization of cancer organoid cell death caused by the immune cell based therapy is provided.
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公开(公告)号：US11561178B2
公开(公告)日：2023-01-24
申请号：US17301975
申请日：2021-04-20
申请人： Tempus Labs, Inc.
发明人： Madhavi Kannan , Brian Larsen , Aly A. Khan , Ameen Salahudeen
IPC分类号： G01N21/64 , G01N33/50 , G02B21/12 , G02B21/00 , G01N21/552 , G06T7/00 , G06N20/00 , G16H30/00 , G06V20/69
摘要： The disclosure provides a method of generating an artificial fluorescent image of cells is provided. The method includes receiving a brightfield image generated by a brightfield microscopy imaging modality of at least a portion of cells included in a specimen, applying, to the brightfield image, at least one trained model, the trained model being trained to generate the artificial fluorescent image based on the brightfield image, receiving the artificial fluorescent image from the trained model
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公开(公告)号：US20220392640A1
公开(公告)日：2022-12-08
申请号：US17771401
申请日：2020-10-22
申请人： Tempus Labs, Inc.
发明人： Ameen Salahudeen , Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号：US10975445B2
公开(公告)日：2021-04-13
申请号：US16789363
申请日：2020-02-12
申请人： Tempus Labs, Inc.
发明人： Aarti Venkat , Jerod Parsons , Joshua S K Bell , Catherine Igartua , Yilin Zhang , Ameen Salahudeen , Verónica Sánchez Freire , Robert Tell
摘要： Methods, systems, and software are provided for determining a homologous recombination pathway status of a cancer in a test subject, e.g., to improve cancer treatment predictions and outcomes. In some embodiments, classifiers using one or more of (i) a heterozygosity status for DNA damage repair genes in a cancerous tissue, (ii) a measure of the loss of heterozygosity across the genome of the cancerous tissue, (iii) a measure of variant alleles detected in a second plurality of DNA damage repair genes in the genome of the cancerous tissue, (iv) a measure of variant alleles detected in the second plurality of DNA damage repair genes in the genome of a non-cancerous tissue, and (v) tumor sample purity are provided.
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8.发明公开公开(公告)号：US20240161519A1
公开(公告)日：2024-05-16
申请号：US18511998
申请日：2023-11-16
申请人： TEMPUS LABS, INC.
发明人： Chi-Sing Ho , Tianyou Luo , Ameen Salahudeen , Luca Lonini
CPC分类号： G06V20/698 , G06T3/40 , G06T7/10 , G06V10/46 , G06V20/695 , G16H30/40 , G06T2207/20132
摘要： A computer-implemented method, computing system and computer-readable medium include receiving training data and training a machine learning model to generate a cell expression map. A computer-implemented method, computing system and computer-readable medium includes receiving a histology image and a cell segmentation map and processing them using a trained machine learning model.
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公开(公告)号：US20230272489A1
公开(公告)日：2023-08-31
申请号：US18300253
申请日：2023-04-13
申请人： Tempus Labs, Inc.
IPC分类号： C12Q1/6886 , C12N5/071 , G16H50/30 , C12M1/32 , G01N33/50 , G16B20/20 , C12N5/09 , C12Q1/02 , C12Q1/6806 , C12Q1/6816
CPC分类号： C12Q1/6886 , C12N5/0691 , G16H50/30 , C12M23/12 , G01N33/5091 , G16B20/20 , C12N5/0693 , C12Q1/025 , C12Q1/6806 , C12Q1/6816 , C12N2500/25 , C12N2527/00 , C12N2521/10 , C12N2509/10 , C12N2501/117 , C12N2501/11 , C12N2501/119 , C12N2501/999 , C12N2501/998 , C12N2533/54 , C12N2533/52 , C12N2533/90 , C12N2501/33 , C12Q1/6844
摘要： Provided herein are novel organoid culture media, organoid culture systems, and methods of culturing tumor organoids using the subject organoid culture media. Also provided herein are tumor organoids developed using such organoid culture systems, methods for assessing the clonal diversity of the tumor organoids, and methods for using such tumor organoids, for example, for tumor modelling and drug development applications. In particular embodiments, the tumor organoid culture media provided herein is substantially free of R-spondins (e.g., R-spondin1).
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公开(公告)号：US11629385B2
公开(公告)日：2023-04-18
申请号：US16693117
申请日：2019-11-22
申请人： Tempus Labs, Inc.
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6886 , C12N5/071 , G16H50/30 , C12M1/32 , G01N33/50 , G16B20/20 , C12N5/09 , C12Q1/02 , C12Q1/6806 , C12Q1/6816 , C12Q1/6844 , C12Q1/6869
摘要： Provided herein are novel organoid culture media, organoid culture systems, and methods of culturing tumor organoids using the subject organoid culture media. Also provided herein are tumor organoids developed using such organoid culture systems, methods for assessing the clonal diversity of the tumor organoids, and methods for using such tumor organoids, for example, for tumor modelling and drug development applications. In particular embodiments, the tumor organoid culture media provided herein is substantially free of R-spondins (e.g., R-spondin1).
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