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公开(公告)号：US11415571B2
公开(公告)日：2022-08-16
申请号：US17114386
申请日：2020-12-07
申请人： Tempus Labs, Inc.
发明人： Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号：US20220392640A1
公开(公告)日：2022-12-08
申请号：US17771401
申请日：2020-10-22
申请人： Tempus Labs, Inc.
发明人： Ameen Salahudeen , Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号：US10975445B2
公开(公告)日：2021-04-13
申请号：US16789363
申请日：2020-02-12
申请人： Tempus Labs, Inc.
发明人： Aarti Venkat , Jerod Parsons , Joshua S K Bell , Catherine Igartua , Yilin Zhang , Ameen Salahudeen , Verónica Sánchez Freire , Robert Tell
摘要： Methods, systems, and software are provided for determining a homologous recombination pathway status of a cancer in a test subject, e.g., to improve cancer treatment predictions and outcomes. In some embodiments, classifiers using one or more of (i) a heterozygosity status for DNA damage repair genes in a cancerous tissue, (ii) a measure of the loss of heterozygosity across the genome of the cancerous tissue, (iii) a measure of variant alleles detected in a second plurality of DNA damage repair genes in the genome of the cancerous tissue, (iv) a measure of variant alleles detected in the second plurality of DNA damage repair genes in the genome of a non-cancerous tissue, and (v) tumor sample purity are provided.
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公开(公告)号：US20220341914A1
公开(公告)日：2022-10-27
申请号：US17857901
申请日：2022-07-05
申请人： Tempus Labs, Inc.
发明人： Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号：US20210172931A1
公开(公告)日：2021-06-10
申请号：US17114386
申请日：2020-12-07
申请人： Tempus Labs, Inc.
发明人： Brian M. Larsen , Michelle M. Stein , Luka A. Karginov , Ameen Salahudeen , Madhavi Kannan , Aly A. Khan , Verónica Sánchez Freire , Yilin Zhang
摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.
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公开(公告)号：US20230272489A1
公开(公告)日：2023-08-31
申请号：US18300253
申请日：2023-04-13
申请人： Tempus Labs, Inc.
IPC分类号： C12Q1/6886 , C12N5/071 , G16H50/30 , C12M1/32 , G01N33/50 , G16B20/20 , C12N5/09 , C12Q1/02 , C12Q1/6806 , C12Q1/6816
CPC分类号： C12Q1/6886 , C12N5/0691 , G16H50/30 , C12M23/12 , G01N33/5091 , G16B20/20 , C12N5/0693 , C12Q1/025 , C12Q1/6806 , C12Q1/6816 , C12N2500/25 , C12N2527/00 , C12N2521/10 , C12N2509/10 , C12N2501/117 , C12N2501/11 , C12N2501/119 , C12N2501/999 , C12N2501/998 , C12N2533/54 , C12N2533/52 , C12N2533/90 , C12N2501/33 , C12Q1/6844
摘要： Provided herein are novel organoid culture media, organoid culture systems, and methods of culturing tumor organoids using the subject organoid culture media. Also provided herein are tumor organoids developed using such organoid culture systems, methods for assessing the clonal diversity of the tumor organoids, and methods for using such tumor organoids, for example, for tumor modelling and drug development applications. In particular embodiments, the tumor organoid culture media provided herein is substantially free of R-spondins (e.g., R-spondin1).
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公开(公告)号：US11629385B2
公开(公告)日：2023-04-18
申请号：US16693117
申请日：2019-11-22
申请人： Tempus Labs, Inc.
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6886 , C12N5/071 , G16H50/30 , C12M1/32 , G01N33/50 , G16B20/20 , C12N5/09 , C12Q1/02 , C12Q1/6806 , C12Q1/6816 , C12Q1/6844 , C12Q1/6869
摘要： Provided herein are novel organoid culture media, organoid culture systems, and methods of culturing tumor organoids using the subject organoid culture media. Also provided herein are tumor organoids developed using such organoid culture systems, methods for assessing the clonal diversity of the tumor organoids, and methods for using such tumor organoids, for example, for tumor modelling and drug development applications. In particular embodiments, the tumor organoid culture media provided herein is substantially free of R-spondins (e.g., R-spondin1).
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公开(公告)号：US20210246511A1
公开(公告)日：2021-08-12
申请号：US17150615
申请日：2021-01-15
申请人： Tempus Labs, Inc.
发明人： Aarti Venkat , Jerod Parsons , Joshua SK Bell , Catherine Igartua , Yilin Zhang , Ameen Salahudeen , Verónica Sánchez Freire , Robert Tell
摘要： Methods, systems, and software are provided for determining a homologous recombination pathway status of a cancer in a test subject, e.g., to improve cancer treatment predictions and outcomes. In some embodiments, classifiers using one or more of (i) a heterozygosity status for DNA damage repair genes in a cancerous tissue, (ii) a measure of the loss of heterozygosity across the genome of the cancerous tissue, (iii) a measure of variant alleles detected in a second plurality of DNA damage repair genes in the genome of the cancerous tissue, (iv) a measure of variant alleles detected in the second plurality of DNA damage repair genes in the genome of a non-cancerous tissue, and (v) tumor sample purity are provided.
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公开(公告)号：US20210155989A1
公开(公告)日：2021-05-27
申请号：US16693117
申请日：2019-11-22
申请人： Tempus Labs, Inc.
摘要： Provided herein are novel organoid culture media, organoid culture systems, and methods of culturing tumor organoids using the subject organoid culture media. Also provided herein are tumor organoids developed using such organoid culture systems, methods for assessing the clonal diversity of the tumor organoids, and methods for using such tumor organoids, for example, for tumor modelling and drug development applications. In particular embodiments, the tumor organoid culture media provided herein is substantially free of R-spondins (e.g., R-spondin1).
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