公开(公告)号：US11415571B2

公开(公告)日：2022-08-16

申请号：US17114386

申请日：2020-12-07

申请人： Tempus Labs, Inc.

发明人： Brian M. Larsen ,  Michelle M. Stein ,  Luka A. Karginov ,  Ameen Salahudeen ,  Madhavi Kannan ,  Aly A. Khan ,  Verónica Sánchez Freire ,  Yilin Zhang

IPC分类号： G01N33/50 ,  G01N33/58

摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.

公开(公告)号：US20220341914A1

公开(公告)日：2022-10-27

申请号：US17857901

申请日：2022-07-05

申请人： Tempus Labs, Inc.

发明人： Brian M. Larsen ,  Michelle M. Stein ,  Luka A. Karginov ,  Ameen Salahudeen ,  Madhavi Kannan ,  Aly A. Khan ,  Verónica Sánchez Freire ,  Yilin Zhang

IPC分类号： G01N33/50 ,  G01N33/58

摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.

公开(公告)号：US20210172931A1

公开(公告)日：2021-06-10

申请号：US17114386

申请日：2020-12-07

申请人： Tempus Labs, Inc.

发明人： Brian M. Larsen ,  Michelle M. Stein ,  Luka A. Karginov ,  Ameen Salahudeen ,  Madhavi Kannan ,  Aly A. Khan ,  Verónica Sánchez Freire ,  Yilin Zhang

IPC分类号： G01N33/50 ,  G01N33/58

摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.

公开(公告)号：US20230145084A1

公开(公告)日：2023-05-11

申请号：US18150194

申请日：2023-01-04

申请人： Tempus Labs, Inc.

发明人： Madhavi Kannan ,  Brian Larsen ,  Aly Khan ,  Ameen Salahudeen

IPC分类号： G01N21/64 ,  G01N33/50 ,  G02B21/12 ,  G02B21/00 ,  G01N21/552 ,  G06T7/00 ,  G06N20/00 ,  G16H30/00 ,  G06V20/69

CPC分类号： G01N21/6458 ,  G01N33/5011 ,  G02B21/12 ,  G02B21/0076 ,  G01N21/553 ,  G06T7/0012 ,  G06N20/00 ,  G16H30/00 ,  G06V20/69 ,  G06T2207/30024

摘要： The disclosure provides a method of generating an artificial immunohistochemistry (IHC) image of cells. The method includes receiving a hematoxylin and eosin (H&E) stained whole slide image (WSI) generated by a brightfield microscopy imaging modality of at least a portion of cells included in a specimen, applying, to the H&E brightfield image, at least one trained model, the trained model being trained to generate the artificial IHC image based on the H&E brightfield image, receiving the artificial IHC image from the trained model.

公开(公告)号：US20210325308A1

公开(公告)日：2021-10-21

申请号：US17301975

申请日：2021-04-20

申请人： Tempus Labs, Inc.

发明人： Madhavi Kannan ,  Brian Larsen ,  Aly A. Khan ,  Ameen Salahudeen

IPC分类号： G01N21/64 ,  G02B21/00 ,  G02B21/12 ,  G01N33/50

摘要： The disclosure provides a method of generating an artificial fluorescent image of cells is provided. The method includes receiving a brightfield image generated by a brightfield microscopy imaging modality of at least a portion of cells included in a specimen, applying, to the brightfield image, at least one trained model, the trained model being trained to generate the artificial fluorescent image based on the brightfield image, receiving the artificial fluorescent image from the trained model

公开(公告)号：US20230036156A1

公开(公告)日：2023-02-02

申请号：US17816395

申请日：2022-07-29

申请人： TEMPUS LABS, INC.

发明人： Chi-Sing Ho ,  Madhavi Kannan ,  Sonal Khare ,  Brian Larsen ,  Brandon Mapes ,  Ameen Salahudeen ,  Jagadish Venkataraman

IPC分类号： G01N33/50 ,  G06T7/00 ,  G06T3/00 ,  G06V20/69 ,  G06T7/11 ,  G06V10/774 ,  G16H15/00 ,  G16H30/40 ,  G01N21/64

摘要： A method for characterizing cancer organoid response to an immune cell based therapy, includes providing a panel of different combinations of cancer organoid cells and immune cells to culturing wells and culturing the different combination under conditions that support organoid growth. Brightfield and corresponding fluorescence images of the culturing wells are captured and provided to one or more trained machine learning algorithms that identify and distinguish cancer organoid cells from immune cells and characterize cancer organoid morphology changes caused by an immune cell based therapies, from which an analytical report including a characterization of cancer organoid cell death caused by the immune cell based therapy is provided.

公开(公告)号：US11561178B2

公开(公告)日：2023-01-24

申请号：US17301975

申请日：2021-04-20

申请人： Tempus Labs, Inc.

发明人： Madhavi Kannan ,  Brian Larsen ,  Aly A. Khan ,  Ameen Salahudeen

IPC分类号： G01N21/64 ,  G01N33/50 ,  G02B21/12 ,  G02B21/00 ,  G01N21/552 ,  G06T7/00 ,  G06N20/00 ,  G16H30/00 ,  G06V20/69

摘要： The disclosure provides a method of generating an artificial fluorescent image of cells is provided. The method includes receiving a brightfield image generated by a brightfield microscopy imaging modality of at least a portion of cells included in a specimen, applying, to the brightfield image, at least one trained model, the trained model being trained to generate the artificial fluorescent image based on the brightfield image, receiving the artificial fluorescent image from the trained model

公开(公告)号：US20220392640A1

公开(公告)日：2022-12-08

申请号：US17771401

申请日：2020-10-22

申请人： Tempus Labs, Inc.

发明人： Ameen Salahudeen ,  Brian M. Larsen ,  Michelle M. Stein ,  Luka A. Karginov ,  Madhavi Kannan ,  Aly A. Khan ,  Verónica Sánchez Freire ,  Yilin Zhang

IPC分类号： G16H50/20 ,  G16B40/20

摘要： Methods, systems, and software are provided for using organoid cultures, e.g., patient-derived tumor organoid cultures, to improve treatment predictions and outcomes.