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公开(公告)号:US20120142078A1
公开(公告)日:2012-06-07
申请号:US11960357
申请日:2007-12-19
CPC分类号: C12N7/00 , A61K2039/5256 , C12N15/86 , C12N2720/12234 , C12N2720/12243 , C12N2799/023
摘要: The present invention provides methods for the generation of viable reoviruses using only cloned nucleic acid segments representing the RNA segments of the reovirus genome.
摘要翻译: 本发明提供了仅使用代表呼肠弧病毒基因组的RNA片段的克隆核酸片段产生活的呼肠弧病毒的方法。
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公开(公告)号:US08293498B2
公开(公告)日:2012-10-23
申请号:US11960357
申请日:2007-12-19
CPC分类号: C12N7/00 , A61K2039/5256 , C12N15/86 , C12N2720/12234 , C12N2720/12243 , C12N2799/023
摘要: The present invention provides methods for the generation of viable reoviruses using only cloned nucleic acid segments representing the RNA segments of the reovirus genome.
摘要翻译: 本发明提供了仅使用代表呼肠弧病毒基因组的RNA片段的克隆核酸片段产生活的呼肠弧病毒的方法。
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公开(公告)号:US09249195B2
公开(公告)日:2016-02-02
申请号:US13639564
申请日:2011-04-04
CPC分类号: C07K14/14 , A61K39/12 , A61K39/21 , A61K2039/5256 , C07K14/005 , C07K2319/40 , C12N2720/12222 , C12N2720/12243 , C12N2740/16122 , C12N2740/16134
摘要: The present invention provides for modified reoviruses that carry α-helical epitopes from a variety of pathogens, as well as methods of using such modified reoviruses to generate immune responses against those epitopes in hosts.
摘要翻译: 本发明提供了携带来自各种病原体的α-螺旋表位的修饰的呼肠孤病毒,以及使用这种修饰的呼肠孤病毒来产生针对宿主中那些表位的免疫应答的方法。
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公开(公告)号:US20130259887A1
公开(公告)日:2013-10-03
申请号:US13639564
申请日:2011-04-04
IPC分类号: C07K14/14
CPC分类号: C07K14/14 , A61K39/12 , A61K39/21 , A61K2039/5256 , C07K14/005 , C07K2319/40 , C12N2720/12222 , C12N2720/12243 , C12N2740/16122 , C12N2740/16134
摘要: The present invention provides for modified reoviruses that carry α-helical epitopes from a variety of pathogens, as well as methods of using such modified reoviruses to generate immune responses against those epitopes in hosts.
摘要翻译: 本发明提供了携带来自各种病原体的α-螺旋表位的修饰的呼肠孤病毒,以及使用这种修饰的呼肠孤病毒来产生针对宿主中那些表位的免疫应答的方法。
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