公开(公告)号：US20240000795A1

公开(公告)日：2024-01-04

申请号：US17945865

申请日：2022-09-15

申请人： Terran Biosciences Inc.

发明人： Sam CLARK

IPC分类号： A61K31/5513 ,  A61K31/519 ,  A61K31/554 ,  A61K45/06 ,  A61P25/14

CPC分类号： A61K31/5513 ,  A61K31/519 ,  A61K31/554 ,  A61K45/06 ,  A61P25/14

摘要： Provided herein are compositions relating to psychedelics and serotonin receptor modulators. Further provided herein are methods of suppressing or halting hallucinogenic effects of a psychedelic and methods of treating a disease or disorder (e.g., depression or diseases or disorders related to depression) comprising administering psychedelics and serotonin receptor modulators.

公开(公告)号：US20230212119A1

公开(公告)日：2023-07-06

申请号：US18173717

申请日：2023-02-23

申请人： Terran Biosciences Inc.

发明人： Matthew Alexander James DUNCTON ,  Sam CLARK

IPC分类号： C07D209/32 ,  C07D209/14 ,  C07D209/12

CPC分类号： C07D209/32 ,  C07D209/14 ,  C07D209/12

摘要： Described herein are compounds that are derivatives of DMT or 5-MeO-DMT and can be metabolically converted to N,N-dimethyltryptamine or analogs thereof upon administration to a subject. In certain embodiments, the compounds described herein are useful for the treatment of conditions associated with a neurological disease.

公开(公告)号：US20240197681A1

公开(公告)日：2024-06-20

申请号：US18553170

申请日：2022-04-01

申请人： Terran Biosciences Inc. ,  University of Maryland, Baltimore

发明人： Sam CLARK ,  Scott THOMPSON

IPC分类号： A61K31/4045 ,  A61K9/20 ,  A61K31/137 ,  A61K31/44 ,  A61K31/522 ,  A61K31/675 ,  A61K39/00 ,  A61K45/06 ,  A61P25/24

CPC分类号： A61K31/4045 ,  A61K9/20 ,  A61K31/137 ,  A61K31/44 ,  A61K31/522 ,  A61K31/675 ,  A61K45/06 ,  A61P25/24 ,  A61K2039/545

摘要： Provided herein are compositions relating to psychedelics and serotonin receptor modulators. Further provided herein are methods of treating a disease or disorder (e.g., depression or diseases or disorders related to depression) comprising administering psychedelics and serotonin receptor modulators.

公开(公告)号：US20240317724A1

公开(公告)日：2024-09-26

申请号：US18576719

申请日：2022-07-07

申请人： Terran Biosciences Inc.

发明人： Sam CLARK ,  Matthew Alexander James DUNCTON

IPC分类号： C07D405/14 ,  A61K31/36 ,  A61K31/4525 ,  A61K31/4545 ,  C07D317/58 ,  C07D405/12 ,  C07D407/12

CPC分类号： C07D405/14 ,  A61K31/36 ,  A61K31/4525 ,  A61K31/4545 ,  C07D317/58 ,  C07D405/12 ,  C07D407/12

摘要： Described herein are compounds that are derivatives (e.g., prodrugs) of 3,4-Methylenedioxymethamphetamine (MDMA). Also described herein are uses of the compounds provided herein for treating or preventing a disease, disorder, or condition in which an increased level of MDMA is beneficial.

公开(公告)号：US20240294460A1

公开(公告)日：2024-09-05

申请号：US18685002

申请日：2022-08-19

申请人： Terran Biosciences Inc.

发明人： Sam CLARK ,  Matthew Alexander James DUNCTON

IPC分类号： C07C217/60 ,  A61K31/137

CPC分类号： C07C217/60 ,  A61K31/137 ,  C07B2200/05

摘要： Provided herein are deuterated analogs of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and related compounds and their uses for the treatment of conditions associated with a neurological disease.

公开(公告)号：US20240116870A1

公开(公告)日：2024-04-11

申请号：US18484211

申请日：2023-10-10

申请人： Terran Biosciences Inc.

发明人： Matthew Alexander James DUNCTON ,  Sam CLARK

IPC分类号： C07D209/32 ,  C07D209/12 ,  C07D209/14

CPC分类号： C07D209/32 ,  C07D209/12 ,  C07D209/14

摘要： Described herein are compounds that are derivatives of DMT or 5-MeO-DMT and can be metabolically converted to N,N-dimethyltryptamine or analogs thereof upon administration to a subject. In certain embodiments, the compounds described herein are useful for the treatment of conditions associated with a neurological disease.