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公开(公告)号:US5219884A
公开(公告)日:1993-06-15
申请号:US465201
申请日:1990-03-01
申请人: Tetsuro Fujita , Takeshi Ikumoto , Shigeo Sasaki , Takeki Okumoto , Kenji Chiba
发明人: Tetsuro Fujita , Takeshi Ikumoto , Shigeo Sasaki , Takeki Okumoto , Kenji Chiba
IPC分类号: C07C229/22 , C07C229/30 , C07D307/33 , C12P13/00 , C12P17/04
CPC分类号: C07D307/33 , C07C229/22 , C07C229/30 , C12P13/001 , C12P13/02 , C12P17/04
摘要: The present invention relates to an immunosuppressive agent which comprises at least one compound selected from the compounds of formula ##STR1## wherein R represents a hydrogen atom or an acyl, Y represents carbonyl or hydroxymethylene and represents a single bond or a double bond and their lactones, in an effective amount and a pharmaceutically acceptable carrier; a method of prophylaxis and therapy for suppressing rejection or autoimmune diseases which comprises administering the above-mentioned compound or its lactone in an effective amount; and a novel compound of formula ##STR2## or its lactone.
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2.
公开(公告)号:US5068247A
公开(公告)日:1991-11-26
申请号:US549137
申请日:1990-07-05
申请人: Tetsuro Fujita , Takeshi Ikumoto , Shigeo Sasaki , Chiba Kenji , Yukio Hoshino
发明人: Tetsuro Fujita , Takeshi Ikumoto , Shigeo Sasaki , Chiba Kenji , Yukio Hoshino
IPC分类号: C07C229/22 , C07C229/30 , C07C251/40 , C07D307/33 , C07D339/06 , C07D409/06 , C07D521/00
CPC分类号: C07D307/33 , C07C229/22 , C07C229/30 , C07C251/40 , C07D231/12 , C07D233/56 , C07D249/08 , C07D339/06 , C07D409/06
摘要: There are disclosed 2-aminopentanoic acid compounds represented by the formula ##STR1## wherein R is as defined in the specification, their optical isomers, their pharmacologically acceptable salts and their use as an immunosuppressant.
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公开(公告)号:US4232159A
公开(公告)日:1980-11-04
申请号:US953275
申请日:1978-10-20
申请人: Ryousuke Touyama , Hiroyuki Inouye , Tetsuro Shingu , Yoshio Takeda , Takeshi Ikumoto , Hidetoshi Okuyama , Osamu Yamamoto
发明人: Ryousuke Touyama , Hiroyuki Inouye , Tetsuro Shingu , Yoshio Takeda , Takeshi Ikumoto , Hidetoshi Okuyama , Osamu Yamamoto
IPC分类号: C07D221/04 , C07D221/02
CPC分类号: C07D221/04
摘要: Novel nitrogen-containing monoterpene derivatives having pyrindine skeleton synthesized by, for example, substitution of an oxygen atom in an iridoid skeleton for a nitrogen atom as low toxic and efficient dyestuffs. Their pharmacological effects are expected.
摘要翻译: 通过例如将环氧乙烷基骨架中的氧原子取代氮原子合成的具有嘧啶骨架的新型含氮单萜衍生物作为低毒高效染料。 预期其药理作用。
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公开(公告)号:US4347356A
公开(公告)日:1982-08-31
申请号:US136080
申请日:1980-03-31
申请人: Ryousuke Touyama , Hiroyuki Inouye , Tetsuro Shingu , Yoshio Takeda , Takeshi Ikumoto , Hidetoshi Okuyama , Osamu Yamamoto
发明人: Ryousuke Touyama , Hiroyuki Inouye , Tetsuro Shingu , Yoshio Takeda , Takeshi Ikumoto , Hidetoshi Okuyama , Osamu Yamamoto
IPC分类号: C07D221/04 , C07D401/06
CPC分类号: C07D221/04 , C09B57/00
摘要: Novel nitrogen-containing monoterpene derivatives having pyrindine skeleton and dimers, trimers and higher polymers thereof as low toxic and efficient dyestuffs. Their pharmacological effects are expected.
摘要翻译: 具有嘧啶骨架和二聚体,三聚物及其较高级聚合物的新型含氮单萜衍生物作为低毒和高效的染料。 预期其药理作用。
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公开(公告)号:US4247698A
公开(公告)日:1981-01-27
申请号:US88725
申请日:1979-08-09
申请人: Ryosuke Toyama , Hiroyuki Inoue , Tetsuro Shingu , Yoshio Takeda , Takeshi Ikumoto , Hidetoshi Okuyama , Osamu Yamamoto
发明人: Ryosuke Toyama , Hiroyuki Inoue , Tetsuro Shingu , Yoshio Takeda , Takeshi Ikumoto , Hidetoshi Okuyama , Osamu Yamamoto
IPC分类号: A23L1/275 , C07D311/94 , C09B57/00 , C09B61/00 , C07D221/02
CPC分类号: C09B61/00 , C07D311/94 , C09B57/00
摘要: PCT No. PCT/JP78/00054 PCT Filed Dec. 14, 1978 Sec. 371 Date Aug. 9, 1979 Sec. 102(e) Date Aug. 9, 1979 PCT Pub. No. WO79/00394 PCT Pub. Date Jul. 12, 1979.Novel reddish coloring compounds of varying hue and the method for its production, obtained by reaction between iridoid compounds contained in biological substances, where if necessary, by pretreatment with chemical or enzymic means to form --COOH at the C-4 position, and in the case of glycosides by hydrolysis of iridoid compounds to aglycones with chemical or microbial or enzymic means, and a substance possessing a primary amino group under acidic condition.
摘要翻译: PCT PCT / JP78 / 00054 PCT 1978年12月14日第Sec。 371日期1979年8月9日 102(e)1979年8月9日PCT公布。 公开号WO79 / 00394 日期1979年7月12日。不同色调的新型淡红色化合物及其生产方法,通过生物物质中所含的环烯醚萜化合物反应获得,如果需要,通过用化学或酶法预处理在C处形成-COOH -4位置,并且在通过化学或微生物或酶法将环烯醚萜烯化合物水解为苷元的糖苷和在酸性条件下具有伯氨基的物质的情况下。
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