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    Immunosuppressive drug
    5.
    发明授权
    Immunosuppressive drug 失效
    免疫抑制药

    公开(公告)号：US5686479A

    公开(公告)日：1997-11-11

    申请号：US244811

    申请日：1994-06-10

    申请人： Takeki Okumoto ,  Kenji Chiba ,  Yukio Hoshino ,  Hirotsugu Komatsu ,  Mariko Nagasawa ,  Hidekazu Aratani ,  Michio Terasawa ,  Minoru Moriwaki

    发明人： Takeki Okumoto ,  Kenji Chiba ,  Yukio Hoshino ,  Hirotsugu Komatsu ,  Mariko Nagasawa ,  Hidekazu Aratani ,  Michio Terasawa ,  Minoru Moriwaki

    IPC分类号： A61K31/55 ,  C07D495/14 ,  C07D495/22 ,  A61K31/41

    CPC分类号： C07D495/14 ,  A61K31/55

    摘要： An immunosuppressive drug, an autoimmune disease treating drug, an immunosuppression enhancing drug and a cell adhesion inhibitor, each containing a thienotriazolodiazepine compound wherein the 2-position of its diazepine ring is alkylated as an active ingredient, an immunosuppression method, an autoimmune disease treating method, an immunosuppression enhancing method and a cell adhesion inhibiting method, each of which comprising administering the compound, and uses of the compound for the production of an immunosuppressive drug, an autoimmune disease treating drug, an immunosuppression enhancing drug and a cell adhesion inhibitor.

    摘要翻译： PCT No.PCT / JP92 / 01619 Sec。 371日期：1994年6月10日 102（e）日期1994年6月10日PCT提交1992年12月10日PCT公布。 公开号WO93 / 12117 日期：1993年6月24日免疫抑制药物，自身免疫疾病治疗药物，免疫抑制增强药物和细胞粘附抑制剂，其各自含有噻吩并三氮杂环庚烯化合物，其中二氮杂环的2位被烷基化为活性成分，免疫抑制法， 一种自身免疫疾病治疗方法，免疫抑制增强方法和细胞粘附抑制方法，其包括施用该化合物，以及该化合物用于制备免疫抑制药物，自身免疫疾病治疗药物，免疫抑制增强药物和 细胞粘附抑制剂。

    Immunosuppressive factor
    6.
    发明授权
    Immunosuppressive factor 失效
    免疫抑制因子

    公开(公告)号：US5037958A

    公开(公告)日：1991-08-06

    申请号：US146167

    申请日：1987-12-12

    申请人： Yoshiyuki Hashimoto ,  Kenji Chiba ,  Hirotsugu Komatsu ,  Takeki Okumoto

    发明人： Yoshiyuki Hashimoto ,  Kenji Chiba ,  Hirotsugu Komatsu ,  Takeki Okumoto

    IPC分类号： C12P21/00 ,  A61K35/12 ,  A61K38/00 ,  A61P37/06 ,  C07K14/005 ,  C07K14/195 ,  C07K14/52 ,  C12R1/91

    CPC分类号： A61K38/1709 ,  A61K35/17 ,  Y10S530/827 ,  Y10S530/829

    摘要： A new immunosuppressive factor derived from human T cell leukemia cells characterized by the following properties:(1) molecular weight: 45,000 to 65,000 daltons and 150,000 to 200,000 daltons by gel filtration, and approximately 31,000 daltons by SDS-polyacrylamide gel electrophoresis;(2) isoelectric point: 4.6 to 4.8;(3) being elutable at a concentration of 0.31 to 0.32 M sodium chloride by FPLC-Mono Q anion exchange chromatography;(4) not adsorbable to immobilized concanavalin A Sepharose or blue Sepharose;(5) resistant to deoxyribonuclease, ribonuclease, papin and periodic acid but sensititive to trypsin, .alpha.-chymotrypsin or pronase;(6) stable at pH 2 to 10;(7) stable for a long time at 4.degree. C. but partially inactivated by heat treatment at 56.degree. C. or 90.degree. C. for 30 minutes;(8) not inhibitable by 2-mercaptoethanol, levamisole, N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, .alpha.-methyl-D-mannoside, L-arginine or L-ornithine;(9) suppressing production of antibody;(10) suppressing blastogeneis of lymphocytes;(11) suppressing cell proliferation; and(12) having structural amino acid and specific contents thereof.This immunosuppressive factor has an excellent immunosuppressing effect and is useful as medicine or reagent.

    Benzene compound and pharmaceutical use thereof
    7.
    发明授权
    Benzene compound and pharmaceutical use thereof 有权
    苯化合物及其药物用途

    公开(公告)号：US06372800B1

    公开(公告)日：2002-04-16

    申请号：US09691099

    申请日：2000-10-19

    申请人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    发明人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    IPC分类号： A61K3135

    CPC分类号： C07C215/56 ,  C07C215/28 ,  C07C215/30 ,  C07C217/64 ,  C07C217/72 ,  C07C219/22 ,  C07C225/16 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/73 ,  C07C271/16 ,  C07C271/18 ,  C07C2601/02

    摘要： A benzene compound of the formula wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behcet's disease, uveal disease, systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifingal agent and hair growth stimulant.

    摘要翻译： 每个符号的苯甲醛的苯化合物如说明书中所定义; 其光学活性异构体或其盐，含有它们的药用组合物和含有该活性成分的免疫抑制剂。该化合物，旋光异构体或盐具有优异的免疫抑制作用，可用作抑制反应发生的抑制剂 在器官或骨髓移植中，作为关节风湿病，特应性湿疹（皮炎），贝切特氏病，葡萄膜疾病，系统性红斑狼疮，Sjögren综合征，多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性 胆汁，肝硬化，克罗恩病，肾小球肾炎，结节病，牛皮癣，天疱疮，再生障碍性贫血，特发性血小板减少性紫癜，变态反应，结节性多动脉炎，进行性系统性硬化症，混合性结缔组织病，主动脉炎综合征，多发性肌炎，皮肌炎，韦格纳肉芽肿，溃疡性结肠炎， 活动性慢性肝炎，自身免疫性溶血性贫血， 伊文思综合征，支气管哮喘和花粉症。 它也可用作抗衰老剂和毛发生长兴奋剂。

    Benzene compound and pharmaceutical use thereof
    8.
    发明授权
    Benzene compound and pharmaceutical use thereof 有权
    苯化合物及其药物用途

    公开(公告)号：US06187821B1

    公开(公告)日：2001-02-13

    申请号：US09309818

    申请日：1999-05-12

    申请人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    发明人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    IPC分类号： A61K31135

    CPC分类号： C07C215/56 ,  C07C215/28 ,  C07C215/30 ,  C07C217/64 ,  C07C217/72 ,  C07C219/22 ,  C07C225/16 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/73 ,  C07C271/16 ,  C07C271/18 ,  C07C2601/02

    摘要： A benzene compound of the formula: wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient. The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behcet's disease, uveal disease, systemic lupus erythematosus, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.

    摘要翻译： 一种下式的苯化合物：其中每个符号如说明书中所定义;光学活性异构体或其盐，含有该化合物的药用组合物和含有该有效成分的免疫抑制剂。化合物，旋光异构体或 盐具有优异的免疫抑制作用，可用作器官或骨髓移植中发生的排斥反应的抑制剂，并且作为关节风湿病，特应性湿疹（皮炎），贝切特氏病，葡萄膜疾病，系统性红斑狼疮， Sjögren综合征，多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性胆汁性肝硬化，克罗恩病，肾小球性肾炎，结节病，牛皮癣，天疱疮，再生障碍性贫血，特发性血小板减少性紫癜，变态反应，结节性多动脉炎，进行性系统性硬化症 组织病，主动脉炎综合征，多发性肌炎，皮肌炎，威基 r肉芽肿，溃疡性结肠炎，活动性慢性肝炎，自身免疫性溶血性贫血，伊文思综合征，支气管哮喘和花粉症。 它也可用作抗真菌剂和毛发生长兴奋剂。

    Benzene compound and pharmaceutical use thereof
    9.
    发明授权
    Benzene compound and pharmaceutical use thereof 失效
    苯化合物及其药物用途

    公开(公告)号：US5948820A

    公开(公告)日：1999-09-07

    申请号：US801390

    申请日：1997-02-20

    申请人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    发明人： Tetsuro Fujita ,  Kunitomo Adachi ,  Toshiyuki Kohara ,  Masatoshi Kiuchi ,  Kenji Chiba ,  Koji Teshima ,  Tadashi Mishina

    IPC分类号： C07C215/28 ,  C07C215/30 ,  C07C215/56 ,  C07C217/64 ,  C07C217/72 ,  C07C219/22 ,  C07C225/16 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/73 ,  C07C271/16 ,  C07C271/18 ,  A61K31/135

    CPC分类号： C07C215/56 ,  C07C215/28 ,  C07C215/30 ,  C07C217/64 ,  C07C217/72 ,  C07C219/22 ,  C07C225/16 ,  C07C233/18 ,  C07C233/31 ,  C07C233/36 ,  C07C233/73 ,  C07C271/16 ,  C07C271/18 ,  C07C2101/02

    摘要： A benzene compound of the formula ##STR1## wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient.The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Beh.cedilla.et's disease, uveal disease, systemic lupus erythematosus, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulonephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.

    摘要翻译： 下式的苯化合物其中每个符号如说明书中所定义; 其光学活性异构体或其盐，含有它们的药用组合物和含有该活性成分的免疫抑制剂。 化合物，光学活性异构体或盐具有优异的免疫抑制作用，可用作器官或骨髓移植中发生的排斥反应的抑制剂，并且作为关节风湿病，特应性湿疹（皮炎）Beh + 525 多发性硬化症，重症肌无力，I型糖尿病，内分泌眼病，原发性胆汁性肝硬化，克罗恩病，肾小球性肾炎，结节病，牛皮癣，天疱疮，多发性硬化症， 再生障碍性贫血，特发性血小板减少性紫癜，过敏，结节性多动脉炎，进行性系统性硬化症，混合性结缔组织病，主动脉炎综合征，多发性肌炎，皮肌炎，韦格纳肉芽肿，溃疡性结肠炎，活动性慢性肝炎，自身免疫性溶血性贫血，伊文思综合征，支气管哮喘和 花粉症 它也可用作抗真菌剂和毛发生长兴奋剂。

    Vehicular exterior member attaching structure and attaching method
    10.
    发明授权
    Vehicular exterior member attaching structure and attaching method 有权
    车辆外部构件的安装结构和安装方法

    公开(公告)号：US09522637B2

    公开(公告)日：2016-12-20

    申请号：US14647265

    申请日：2013-11-25

    申请人： KABUSHIKI KAISHA TOYOTA JIDOSHOKKI ,  TOYOTA JIDOSHA KABUSHIKI KAISHA ,  Kenji Chiba

    发明人： Kenji Chiba ,  Muneaki Inagaki

    IPC分类号： B60R13/04 ,  B60R19/24 ,  B60R19/18

    CPC分类号： B60R13/04 ,  B60R19/24 ,  B60R2019/1886

    摘要： A vehicle exterior member attaching structure for attaching a vehicle exterior member onto a protruding target location of a vehicle includes a vehicle engagement portion located at a target section, an attachment hole located at the target section, a covering portion located on the vehicle exterior member, an engagement portion located on the covering portion and configured to be engaged with the vehicle engagement portion, and an attachment piece located on the covering portion and configured to be inserted into the attachment hole. The covering portion and the attachment piece are integrally formed with a portion of the attachment piece connected to the covering portion forming a thin integral hinge.

    摘要翻译： 一种用于将车辆外部构件附接到车辆的突出目标位置的车辆外部构件附接结构，包括：位于目标区域的车辆接合部，位于目标区域处的安装孔，位于车辆外部构件上的覆盖部， 位于所述覆盖部上并且被构造成与所述车辆接合部接合的接合部，以及位于所述覆盖部上并被构造成插入所述安装孔中的安装片。 覆盖部分和附接件与连接到覆盖部分的连接件的一部分整体形成，形成薄的整体铰链。