公开(公告)号：US09060857B2

公开(公告)日：2015-06-23

申请号：US13526951

申请日：2012-06-19

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US20060265056A1

公开(公告)日：2006-11-23

申请号：US11433296

申请日：2006-05-12

申请人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

公开(公告)号：US20060259136A1

公开(公告)日：2006-11-16

申请号：US11128826

申请日：2005-05-13

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

公开(公告)号：US20150127095A9

公开(公告)日：2015-05-07

申请号：US13526951

申请日：2012-06-19

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US08226710B2

公开(公告)日：2012-07-24

申请号：US13072194

申请日：2011-03-25

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US20110172765A1

公开(公告)日：2011-07-14

申请号：US13072194

申请日：2011-03-25

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US07914569B2

公开(公告)日：2011-03-29

申请号：US11128826

申请日：2005-05-13

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US09504564B2

公开(公告)日：2016-11-29

申请号：US11433296

申请日：2006-05-12

申请人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

公开(公告)号：USD732666S1

公开(公告)日：2015-06-23

申请号：US29399122

申请日：2011-08-09

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

设计人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

公开(公告)号：US20120259409A1

公开(公告)日：2012-10-11

申请号：US13526951

申请日：2012-06-19

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。