公开(公告)号：US20170172987A1

公开(公告)日：2017-06-22

申请号：US15127603

申请日：2015-03-20

Applicant: The Board of Regents of the University of Texas System

Inventor： Joachim HERZ ,  Gang YU ,  Bruce POSNER ,  Basar CENIK

IPC: A61K31/422 ,  A61K31/42 ,  A61K31/423 ,  A61K31/5377 ,  A61K31/404 ,  A61K45/06 ,  A61K31/454

CPC classification number: A61K31/422 ,  A61K31/404 ,  A61K31/42 ,  A61K31/423 ,  A61K31/454 ,  A61K31/5377 ,  A61K45/06 ,  C07D209/40 ,  C07D261/18 ,  C07D263/56 ,  C07D413/04 ,  C07D413/14 ,  C07D495/04

Abstract: The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of frontotemporal dementia.

公开(公告)号：US20200333357A1

公开(公告)日：2020-10-22

申请号：US16763518

申请日：2018-11-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Michael A. WHITE ,  Chensu WANG ,  Yang LI ,  Bruce POSNER ,  Gang HUANG

IPC: G01N33/68 ,  C08F293/00 ,  A61K49/00

Abstract: The present disclosure is directed to a nanotechnology-enabled screening strategy to identify small molecule TFEB agonists that shift maturation of autophagosomes to degradative autolysosomes.