公开(公告)号：US20180369424A1

公开(公告)日：2018-12-27

申请号：US16114187

申请日：2018-08-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Xinpeng MA ,  Yiguang WANG ,  Yang LI ,  Baran D. SUMER

IPC: A61K49/00 ,  C09B69/10 ,  G01N33/84 ,  G01N33/58 ,  G01N21/64 ,  C08F8/42 ,  C08F8/34 ,  C08F8/32 ,  C08F8/30

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US20170143852A1

公开(公告)日：2017-05-25

申请号：US15369701

申请日：2016-12-05

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Xinpeng MA ,  Yiguang WANG ,  Yang LI ,  Baran D. SUMER

IPC: A61K49/00 ,  G01N33/58 ,  C08F8/30 ,  G01N21/64 ,  C08F8/32 ,  C08F8/34 ,  C09B69/10 ,  G01N33/84 ,  C08F8/42

CPC classification number: A61K49/0054 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0041 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/103 ,  C09B69/105 ,  C09B69/106 ,  C09B69/109 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/6456 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US20210338840A1

公开(公告)日：2021-11-04

申请号：US17231922

申请日：2021-04-15

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Xinpeng MA ,  Yiguang WANG ,  Yang LI ,  Baran D. SUMER

IPC: A61K49/00 ,  G01N21/64 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/10 ,  G01N33/58 ,  G01N33/84

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US20240115741A1

公开(公告)日：2024-04-11

申请号：US18449675

申请日：2023-08-14

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Xinpeng MA ,  Yiguang WANG ,  Yang LI ,  Baran D. SUMER

IPC: A61K49/00 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/10 ,  G01N21/64 ,  G01N33/58 ,  G01N33/84

CPC classification number: A61K49/0054 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0041 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/103 ,  C09B69/105 ,  C09B69/106 ,  C09B69/109 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/6456 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US20200333357A1

公开(公告)日：2020-10-22

申请号：US16763518

申请日：2018-11-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Michael A. WHITE ,  Chensu WANG ,  Yang LI ,  Bruce POSNER ,  Gang HUANG

IPC: G01N33/68 ,  C08F293/00 ,  A61K49/00

Abstract: The present disclosure is directed to a nanotechnology-enabled screening strategy to identify small molecule TFEB agonists that shift maturation of autophagosomes to degradative autolysosomes.