公开(公告)号：US20180291134A1

公开(公告)日：2018-10-11

申请号：US16006885

申请日：2018-06-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: C08F293/00 ,  A61K31/704 ,  A61K47/62 ,  A61K47/68 ,  C07D311/92 ,  A61K49/00 ,  A61K47/58 ,  A61K31/352 ,  A61K31/337 ,  A61K9/50 ,  A61K9/127 ,  A61K9/107 ,  C08F220/34

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20170143852A1

公开(公告)日：2017-05-25

申请号：US15369701

申请日：2016-12-05

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Xinpeng MA ,  Yiguang WANG ,  Yang LI ,  Baran D. SUMER

IPC: A61K49/00 ,  G01N33/58 ,  C08F8/30 ,  G01N21/64 ,  C08F8/32 ,  C08F8/34 ,  C09B69/10 ,  G01N33/84 ,  C08F8/42

CPC classification number: A61K49/0054 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0041 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/103 ,  C09B69/105 ,  C09B69/106 ,  C09B69/109 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/6456 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US20170049911A1

公开(公告)日：2017-02-23

申请号：US15297862

申请日：2016-10-19

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Kejin ZHOU ,  Baran D. SUMER

IPC: A61K49/00 ,  G01N33/50

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。

公开(公告)号：US20200333350A1

公开(公告)日：2020-10-22

申请号：US16814898

申请日：2020-03-10

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: G01N33/58

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20200087451A1

公开(公告)日：2020-03-19

申请号：US16570337

申请日：2019-09-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Baran D. SUMER ,  Xiankai SUN

IPC: C08G65/00 ,  A61K49/00 ,  G01N33/58 ,  G01N33/84 ,  G01N21/64

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US20190060446A1

公开(公告)日：2019-02-28

申请号：US16081911

申请日：2017-03-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jinming GAO ,  Zhijian CHEN ,  Min LUO ,  Zhaohui WANG ,  Hua WANG ,  Haocheng CAI ,  Gang HUANG ,  Yang-Xin FU

IPC: A61K39/39 ,  A61K39/00 ,  A61K9/51 ,  A61K39/145

Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.

公开(公告)号：US20180369424A1

公开(公告)日：2018-12-27

申请号：US16114187

申请日：2018-08-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Xinpeng MA ,  Yiguang WANG ,  Yang LI ,  Baran D. SUMER

IPC: A61K49/00 ,  C09B69/10 ,  G01N33/84 ,  G01N33/58 ,  G01N21/64 ,  C08F8/42 ,  C08F8/34 ,  C08F8/32 ,  C08F8/30

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US20180099002A1

公开(公告)日：2018-04-12

申请号：US15834052

申请日：2017-12-06

Applicant: The Board of Regents of the University of Texas System ,  The Board of Trustees of the University of Illinois

Inventor： Paul J. HERGENROTHER ,  David A. BOOTHMAN ,  Joseph S. BAIR ,  Lifen CAO ,  Jinming GAO ,  Xiumei HUANG ,  Xiuquan LUO ,  Xinpeng MA ,  Zachary R. MOORE ,  Elizabeth I. PARKINSON

IPC: A61K31/706 ,  A61K31/4745 ,  A61K31/4738 ,  A61K31/131 ,  A61K45/06 ,  C12Q1/6886 ,  A61K31/353

Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

公开(公告)号：US20250009656A1

公开(公告)日：2025-01-09

申请号：US18710555

申请日：2022-11-15

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Zhichen SUN ,  Qiang FENG ,  Wei LI

IPC: A61K9/107 ,  A61K38/20 ,  A61K47/34 ,  A61K47/64 ,  A61K47/68 ,  C08F293/00

Abstract: Ultra pH sensitive (UPS) micelles encapsulating cytokines are provided that provide lower toxicity and higher efficacy compositions and methods for treating cancer with those compositions.

公开(公告)号：US20240115741A1

公开(公告)日：2024-04-11

申请号：US18449675

申请日：2023-08-14

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming GAO ,  Gang HUANG ,  Tian ZHAO ,  Xinpeng MA ,  Yiguang WANG ,  Yang LI ,  Baran D. SUMER

IPC: A61K49/00 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/10 ,  G01N21/64 ,  G01N33/58 ,  G01N33/84

CPC classification number: A61K49/0054 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0041 ,  C08F8/30 ,  C08F8/32 ,  C08F8/34 ,  C08F8/42 ,  C09B69/103 ,  C09B69/105 ,  C09B69/106 ,  C09B69/109 ,  G01N21/6428 ,  G01N21/643 ,  G01N21/6456 ,  G01N33/582 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.