公开(公告)号：US20170349543A1

公开(公告)日：2017-12-07

申请号：US15597049

申请日：2017-05-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Jason B. Miller

IPC: C07C311/32 ,  C07C309/14 ,  C12N15/113 ,  C12N15/11 ,  A61K48/00 ,  C12N2310/20

Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

公开(公告)号：US12252464B2

公开(公告)日：2025-03-18

申请号：US18315446

申请日：2023-05-10

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. Siegwart ,  Jason B. Miller

IPC: C07C311/32 ,  A61K47/54 ,  A61K47/69 ,  A61K48/00 ,  B82Y5/00 ,  C07C229/06 ,  C07C309/14 ,  C07F9/09 ,  C07F9/10 ,  C12N15/11 ,  C12N15/113 ,  C12N15/88

Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

公开(公告)号：US10562849B2

公开(公告)日：2020-02-18

申请号：US15597049

申请日：2017-05-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Jason B. Miller

IPC: C07C311/32 ,  A61K48/00 ,  C07C309/14 ,  C12N15/11 ,  C12N15/113

Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

公开(公告)号：US11685710B2

公开(公告)日：2023-06-27

申请号：US17399774

申请日：2021-08-11

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Jason B. Miller

IPC: C07C311/32 ,  C12N15/88 ,  C07F9/09 ,  C07F9/10 ,  C12N15/11 ,  B82Y5/00 ,  C07C229/06 ,  A61K47/69 ,  A61K47/54 ,  A61K48/00 ,  C07C309/14 ,  C12N15/113

CPC classification number: C07C311/32 ,  A61K47/543 ,  A61K47/6911 ,  A61K48/0033 ,  B82Y5/00 ,  C07C229/06 ,  C07C309/14 ,  C07F9/091 ,  C07F9/106 ,  C12N15/11 ,  C12N15/111 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2310/20 ,  C12N2320/32

Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas:




wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

公开(公告)号：US11542229B2

公开(公告)日：2023-01-03

申请号：US16744118

申请日：2020-01-15

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Jason B. Miller

IPC: C07C311/32 ,  C12N15/88 ,  C07F9/09 ,  C07F9/10 ,  C12N15/11 ,  B82Y5/00 ,  C07C229/06 ,  A61K47/69 ,  A61K47/54 ,  A61K48/00 ,  C07C309/14 ,  C12N15/113

Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.

公开(公告)号：US20210023120A1

公开(公告)日：2021-01-28

申请号：US17064505

申请日：2020-10-06

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Philip J. Thomas ,  Arthur E. Johnson ,  Michael J. Torres ,  Jason B. Miller

IPC: A61K31/7105 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7088 ,  A61K47/18 ,  A61K47/20 ,  A61K47/34

Abstract: In some aspects, the present disclosure provides a nanoparticle composition comprising tRNA and an aminolipid delivery compound. The aminolipid delivery compound may be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid with one or more hydrophobic components. In some embodiments, these compositions may be administered to a patient to treat a genetic disease or disorder such as cystic fibrosis, Duchene muscular dystrophy, or cancer.

公开(公告)号：US20170354672A1

公开(公告)日：2017-12-14

申请号：US15597063

申请日：2017-05-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Philip J. Thomas ,  Arthur E. Johnson ,  Michael J. Torres ,  Jason B. Miller

IPC: A61K31/7105 ,  A61K47/18 ,  A61K47/20 ,  A61K47/34

CPC classification number: A61K31/7105 ,  A61K9/127 ,  A61K9/5123 ,  A61K31/7088 ,  A61K47/18 ,  A61K47/20 ,  A61K47/34

Abstract: In some aspects, the present disclosure provides a nanoparticle composition comprising tRNA and an aminolipid delivery compound. The aminolipid delivery compound may be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid with one or more hydrophobic components. In some embodiments, these compositions may be administered to a patient to treat a genetic disease or disorder such as cystic fibrosis, Duchene muscular dystrophy, or cancer.