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公开(公告)号：US20240092760A1
公开(公告)日：2024-03-21
申请号：US18334325
申请日：2023-06-13
Inventor： Jian QIU , Qi WEI , Matt TSCHANTZ , Heping SHI , Youtong WU , Huiling TAN , Lijun SUN , Chuo CHEN , Zhijian CHEN
IPC: C07D401/14 , C07D215/38 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/6503 , C07F9/6506
CPC classification number: C07D401/14 , C07D215/38 , C07D215/42 , C07D215/46 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D491/048 , C07F9/65031 , C07F9/6506
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US20210290774A1
公开(公告)日：2021-09-23
申请号：US17317864
申请日：2021-05-11
Inventor： Zhijian CHEN , Heping SHI , Qi WEI , Chuo CHEN , Lijun SUN , Jian QIU , Youtong WU
Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
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公开(公告)号：US20220340613A1
公开(公告)日：2022-10-27
申请号：US17697247
申请日：2022-03-17
Inventor： Boyu ZHONG , Heping SHI , Yuanwei DAI , Qi WEI , Chuo CHEN , Zhijian CHEN , Lijun SUN
IPC: C07H21/02 , A61K45/06 , C07H21/00 , A61K31/7084 , C07H21/04
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US20180230177A1
公开(公告)日：2018-08-16
申请号：US15953492
申请日：2018-04-15
Inventor： Boyu ZHONG , Lijun SUN , Heping SHI , Qi WEI , Yuanwei DAI , Chuo CHEN , Zhijian CHEN
IPC: C07H21/02 , A61K31/7084 , A61K45/06 , C07H21/04
CPC classification number: C07H21/02 , A61K31/7084 , A61K45/06 , C07H21/00 , C07H21/04
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US20210015941A1
公开(公告)日：2021-01-21
申请号：US16933845
申请日：2020-07-20
Inventor： Zhijian CHEN , Heping SHI , Qi WEI , Chuo CHEN , Lijun SUN , Jian QIU , Youtong WU
Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
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Patent Agency Ranking
公开(公告)号：US20240002346A1
公开(公告)日：2024-01-04
申请号：US18177732
申请日：2023-03-02
Inventor： Qi WEI , Heping SHI , Matt TSCHANTZ , Jian QIU , Youtong WU , Huiling TAN , Lijun SUN , Chuo CHEN , Zhijian CHEN
IPC: C07D215/12 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14
CPC classification number: C07D215/12 , C07D401/04 , C07D401/14 , C07D417/14 , C07D413/14 , C07D409/14 , C07D405/14
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US20230081291A1
公开(公告)日：2023-03-16
申请号：US17446951
申请日：2021-09-03
Inventor： Jian QIU , Qi WEI , Matt TSCHANTZ , Heping SHI , Youtong WU , Huiling TAN , Lijun SUN , Chuo CHEN , Zhijian CHEN
IPC: C07D401/14 , C07D401/04 , C07D413/14 , C07D403/04 , C07D409/14 , C07D417/14 , C07D471/08 , C07D405/14 , C07F9/6506 , C07F9/6503 , C07D215/38 , C07D215/42 , C07D215/46 , C07D491/048
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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公开(公告)号：US20220105198A1
公开(公告)日：2022-04-07
申请号：US17553624
申请日：2021-12-16
Inventor： Zhijian CHEN , Heping SHI , Qi WEI , Chuo CHEN , Lijun SUN , Jian QIU , Youtong WU
Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
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公开(公告)号：US20200010501A1
公开(公告)日：2020-01-09
申请号：US16438153
申请日：2019-06-11
Inventor： Boyu ZHONG , Heping SHI , Yuanwei DAI , Qi WEI , Chuo CHEN , Zhijian CHEN , Lijun SUN
IPC: C07H21/02 , C07H21/04 , A61K31/7084 , A61K45/06
Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
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公开(公告)号：US20230357158A1
公开(公告)日：2023-11-09
申请号：US18353718
申请日：2023-07-17
Inventor： Qi WEI , Heping SHI , Matt TSCHANTZ , Jian QIU , Youtong WU , Huiling TAN , Lijun SUN , Chuo CHEN , Zhijian CHEN
IPC: C07D215/12 , C07D417/14 , C07D413/14 , C07D405/14 , C07D401/04 , C07D401/14 , C07D409/14
CPC classification number: C07D215/12 , C07D417/14 , C07D413/14 , C07D405/14 , C07D401/04 , C07D401/14 , C07D409/14
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
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