公开(公告)号：US20220273779A1

公开(公告)日：2022-09-01

申请号：US17295152

申请日：2019-11-18

Applicant: The Board of Regents of the University of Texas System

Inventor： Marc I. DIAMOND ,  Kenneth DROMBOSKY ,  Dailu CHEN ,  Victor MANON ,  Xiaohua LIU ,  Hamid MIRZAEI ,  Jaime VAQUER-ALICEA ,  Hilda MIRBAHA ,  Lukasz A. JOACHIMIAK

IPC: A61K39/00 ,  A61P25/28 ,  A61K38/16 ,  A61K38/03 ,  A61K9/00

Abstract: The disclosure provides methods and compositions for treating and diagnosing tauopathies. More specifically, the disclosure relates to the identification of epitopes on tau and their use as vaccines or as reagents to generate monoclonal antibodies that can be used for both diagnosis and treatment of tau-related diseases.

公开(公告)号：US20240043483A1

公开(公告)日：2024-02-08

申请号：US18266712

申请日：2021-12-21

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Marc DIAMOND ,  Victor MANON ,  Jaime VAQUER-ALICEA ,  Brian HITT

IPC: C07K14/47 ,  C12N15/63 ,  G01N33/68 ,  G01N33/50

CPC classification number: C07K14/4711 ,  C12N15/63 ,  G01N33/6896 ,  G01N33/5058

Abstract: The present disclosure provides biosensor cells and methods of use thereof. The disclosure provides, for example, methods of measuring a titer of or of detecting a seed tau protein in a sample, methods of detecting Alzheimer's disease (AD), or a neurodegenerative tauopathy disease or condition linked to tau protein aggregation, and methods for the identification of putative tau protein aggregation inhibitors or modulators.