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公开(公告)号：US10774383B2
公开(公告)日：2020-09-15
申请号：US16014900
申请日：2018-06-21
IPC分类号： C12Q1/68 , C12Q1/6883
摘要： High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.
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公开(公告)号：US20160333405A1
公开(公告)日：2016-11-17
申请号：US15040887
申请日：2016-02-10
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q1/6874 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/124 , C12Q2600/156 , C12Q2600/16 , C40B50/06 , G06F19/18 , G06F19/22 , C12Q2535/122
摘要： A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.
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3.发明申请公开(公告)号：US20150292009A1
公开(公告)日：2015-10-15
申请号：US14735066
申请日：2015-06-09
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q1/6874 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/124 , C12Q2600/156 , C12Q2600/16 , C40B50/06 , G06F19/18 , G06F19/22 , C12Q2535/122
摘要： A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.
摘要翻译： 通过序列分析获得样品中存在的免疫受体多样性的精确测量。 感兴趣的样品通常是复杂的，其包含针对感兴趣受体的102,103,104,105,106,107,108,109,1010,1011,1012或更多不同的序列。 感兴趣的免疫受体包括免疫球蛋白，T细胞抗原受体和主要的组织相容性受体。 可以记录和输出样品中免疫受体序列变异的具体组成。 该组合物可用于与个体的免疫能力和历史有关的预测，诊断和治疗方法。 这种预测和诊断用于指导临床决策。
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公开(公告)号：US20210002722A1
公开(公告)日：2021-01-07
申请号：US16931102
申请日：2020-07-16
IPC分类号： C12Q1/6876 , G16B20/00 , G16B30/00 , C12Q1/6883 , C12Q1/6809 , C12Q1/6886
摘要： A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.
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公开(公告)号：US09909180B2
公开(公告)日：2018-03-06
申请号：US14172642
申请日：2014-02-04
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.
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公开(公告)号：US10774382B2
公开(公告)日：2020-09-15
申请号：US16119602
申请日：2018-08-31
IPC分类号： C40B30/04 , C12Q1/6876 , G16B20/00 , G16B30/00 , C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C40B50/06 , C12Q1/6874
摘要： A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.
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公开(公告)号：US20180127827A1
公开(公告)日：2018-05-10
申请号：US15848715
申请日：2017-12-20
IPC分类号： C12Q1/6883
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.
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公开(公告)号：US20210054461A1
公开(公告)日：2021-02-25
申请号：US17009386
申请日：2020-09-01
IPC分类号： C12Q1/6883
摘要： High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.
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公开(公告)号：US10196689B2
公开(公告)日：2019-02-05
申请号：US15040887
申请日：2016-02-10
IPC分类号： C40B50/06 , C12Q1/6876 , C12Q1/6883 , C12Q1/6809 , G06F19/18 , G06F19/22 , C12Q1/6886 , C12Q1/6874
摘要： A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.
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公开(公告)号：US20190024171A1
公开(公告)日：2019-01-24
申请号：US16119602
申请日：2018-08-31
IPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q1/6883 , C12Q1/6886 , G06F19/22 , G06F19/18 , C12Q1/6874 , C40B50/06
摘要： A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 102, 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012 or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.
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