专利检索 ap:("The Board of Trustees of the Leland Stanford Junior University") AND inv:"Sunhee Hwang" 第 1 页

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发明申请
Glucose-6-Phosphate Dehydrogenase (G6PD)-Modulating Agents And Methods Of Treating G6PD Deficiency 审中-公开

公开(公告)号：US20200223826A1

公开(公告)日：2020-07-16

申请号：US16632863

申请日：2018-07-24

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Sunhee Hwang , DARIA MOCHLY-ROSEN , CHE-HONG CHEN , Andrew Goodwin Raub

IPC分类号： C07D403/10 , C07D407/10 , C07D407/12 , C07D403/12 , C07C215/32 , C07C225/16 , C07D401/12 , C07D409/12 , C07C211/27 , C07C211/42 , C07D487/04 , C07D471/04 , C07D471/06

摘要： Aspects of the present disclosure include G6PD-modulating agents and methods for modulating a glucose-6-phosphate dehydrogenase (G6PD) in a sample using such agents. A G6PD-modulating agent can be dimeric and include two terminal carbocyclic or heterocyclic groups connected via a linker. In some instances, the agent includes a diamino-containing linker. In certain cases, the agent includes two amino substituents. Also provided are methods for treating a subject for a G6PD deficiency-associated condition, that include administering to a subject an effective amount of a G6PD-modulating agent to selectively activate a mutant G6PD and treat the subject. Kits and compositions for practicing the subject methods are also provided.