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公开(公告)号：US20220404373A1
公开(公告)日：2022-12-22
申请号：US17762594
申请日：2020-09-24
Inventor： Vinit Mahajan
Abstract: Compositions, methods, and kits are provided for diagnosing and treating uveitis. In particular, biomarkers have been identified that can be used to distinguish infectious uveitis from noninfectious uveitis, and further discriminate among bacterial, viral, and fungal uveitis. These biomarkers can be used alone or in combination with one or more additional biomarkers or relevant clinical parameters in prognosis, diagnosis, or monitoring treatment of uveitis.
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公开(公告)号：US20230034053A1
公开(公告)日：2023-02-02
申请号：US17763083
申请日：2020-09-24
Inventor： Vinit Mahajan , Katherine J. Wert , Gabriel Velez
IPC: A61K31/215 , A61K31/07 , A61K31/525 , A61K31/455 , A61K31/23 , A61K31/202 , A61K31/047 , G01N33/68
Abstract: Methods are provided for treating and diagnosing diseases and disorders associated with retinal degeneration, such as retinitis pigmentosa. Dietary supplementation with specific metabolites and vitamins can prolong vision and provide a neuroprotective effect. In particular, dietary supplementation with α-ketoglutarate, or a derivative thereof, significantly prolongs photoreceptor cell survival and visual function. In addition, dietary supplementation with B vitamins and a ketogenic diet also improves photoreceptor cell survival and delays disease progression in some cases. Additionally, compositions, methods, and kits are provided for diagnosing a subject with retinitis pigmentosa based on expression levels of vitreous biomarkers.
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Patent Agency Ranking
公开(公告)号：US20240353426A1
公开(公告)日：2024-10-24
申请号：US18683069
申请日：2022-08-11
Inventor： Vinit Mahajan , Gabriel Velez , Cassie Ann Ludwig
IPC: G01N33/68 , A61K31/155 , A61K31/573 , A61K38/17 , A61K39/00
CPC classification number: G01N33/6893 , A61K31/155 , A61K31/573 , A61K38/179 , A61K2039/505 , G01N2800/042 , G01N2800/16 , G01N2800/52
Abstract: Compositions, methods, and kits are provided for diagnosing and treating proliferative diabetic retinopathy. The identified biomarkers can be used alone or in combination with one or more additional biomarkers or relevant clinical parameters in prognosis, diagnosis, or monitoring treatment of proliferative diabetic retinopathy. Methods of treating a subject for proliferative diabetic retinopathy are also provided.
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公开(公告)号：US20230152322A1
公开(公告)日：2023-05-18
申请号：US17796179
申请日：2021-01-29
Inventor： Vinit Mahajan , Gabriel Velez , Prithvi Mruthyunjaya
IPC: G01N33/574 , C12Q1/6886
CPC classification number: G01N33/57407 , G01N33/57488 , C12Q1/6886 , C12Q2600/158 , C12Q2600/156
Abstract: Compositions, methods, and kits are provided for diagnosing and treating uveal melanoma. In particular, biomarkers have been identified that can be used to diagnose uveal melanoma and subtype eye tumors according to their gene expression profile (GEP) class or PRAME status. These biomarkers can be used alone or in combination with one or more additional biomarkers or relevant clinical parameters in prognosis, diagnosis, or monitoring treatment of uveal melanoma.
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公开(公告)号：US20220364142A1
公开(公告)日：2022-11-17
申请号：US17767280
申请日：2020-10-09
Applicant: The Board of Trustees of the Leland Stanford Junior University , The United States Government as represented by the Department of Veterans Affairs , UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Vinit Mahajan , Gabriel Velez , Young Joo Sun , Kellie A Schaefer , Alexander G Bassuk
Abstract: Compositions, methods, and kits are provided for assaying calpain-5 activity and inhibition. In particular, novel peptide substrates are provided for detecting calpain-5, measuring calpain-5 activity, and screening for inhibitors of calpain-5 to identify potential therapeutic agents for treating retinal diseases and other diseases associated with calpain-5 hyperactivity. Additionally, novel inhibitors of calpain-5 are also provided.
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公开(公告)号：US20240120032A1
公开(公告)日：2024-04-11
申请号：US18030046
申请日：2021-10-14
Applicant: The Board of Trustees of the Leland Stanford Junior University , The United States Government as represented by the Department of Veterans Affairs
Inventor： Vinit Mahajan , Young Joo Sun , Gabriel Velez , Dylan Parsons
CPC classification number: G16C20/30 , C12N9/6472 , G16C20/50 , G16C20/64 , C12Y304/22
Abstract: A high-resolution crystallographic structure of the mutant human G267S calpain-5 protease core domain at 2.22 Å resolution is provided. The G267S mutation is associated with hyperactivity of calpain-5 and is linked to the inherited disease, neovascular inflammatory vitreoretinopathy. Methods of using the crystallographic structure in rational design of small molecule drugs that inhibit calpain-5 for treatment of retinal diseases and other diseases associated with calpain-5 hyperactivity are also provided.
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公开(公告)号：US20220362407A1
公开(公告)日：2022-11-17
申请号：US17762591
申请日：2020-09-24
Applicant: The Board of Trustees of the Leland Stanford Junior University , The United States Govemment as represented by the Department of Veterans Affairs
Inventor： Vinit Mahajan , Katherine J. Wert
Abstract: A construct comprising a promoter specific for non-pigmented ciliary epithelial cells (NPCECs) is provided. In particular, the construct comprises a BEST2 minimal promoter that confers NPCEC-specific expression. The BEST2 minimal promoter may be operably linked to an expressible sequence such as a gene encoding a polypeptide of interest, a regulatory RNA sequence, a reporter gene, and the like. Such constructs may be provided in an expression vector, for example, with the BEST2 minimal promoter operably linked to an expressible sequence or in a host cell genetically modified with such an expression vector.
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